The presence of clusters of rare codons is known to negatively impact the efficiency and accuracy of protein production. In this paper, we demonstrate a statistical method of identifying such clusters in the coding sequence of a gene. Using E. coli as our model organism, we show that genes having denser clusters tend to have lower protein yields.
@article{arxiv.0910.0429,
title = {On the clustering of rare codons and its effect on translation},
author = {Lalit Ponnala},
journal= {arXiv preprint arXiv:0910.0429},
year = {2009}
}