Related papers: On a diffuse interface model for tumour growth wit…
Phase-field models are a popular choice in computational physics to describe complex dynamics of substances with multiple phases and are widely used in various applications. We present nonlocal non-isothermal phase-field models of…
In this paper, we study the sharp interface limit for solutions of the Cahn-Hilliard equation with disparate mobilities. This means that the mobility function degenerates in one of the two energetically favorable configurations, suppressing…
We derive a system of equations which can be seen as an evolving surface version of the diffuse interface "Model H" of Hohenberg and Halperin (1977). We then consider the well-posedness for the corresponding (tangential) system when one…
We present a new diffuse interface model for the dynamics of inextensible vesicles in a viscous fluid. A new feature of this work is the implementation of the local inextensibility condition in the diffuse interface context. Local…
We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…
The mathematical modeling of tumor growth leads to singular stiff pressure law limits for porous medium equations with a source term. Such asymptotic problems give rise to free boundaries, which, in the absence of active motion, are…
Phase-field models of tumour growth have proved useful as theoretical tools to investigate cancer invasion. A key implicit assumption underlying mathematical models of this type which have so far been proposed, though, is that cells in the…
We analyze a diffuse interface model that couples a viscous Cahn-Hilliard equation for the phase variable with a diffusion-reaction equation for the nutrient concentration. The system under consideration also takes into account some…
A diffuse-interface model that describes the dynamics of nonhomogeneous incompressible two-phase viscous flows is investigated in a bounded smooth domain in ${\mathbb R}^3.$ The dynamics of the state variables is described by the…
A mathematical analysis of local and nonlocal phase-field models of tumor growth is presented that includes time-dependent Darcy-Forchheimer-Brinkman models of convective velocity fields and models of long-range cell interactions. A…
The tumour microenvironment plays a fundamental role in understanding the development and progression of cancer. This paper proposes a novel spatial point process model that accounts for inhomogeneity and interaction to flexibly model a…
In the bistable regime of the FitzHugh-Nagumo model of reaction-diffusion systems, spatially homogeneous patterns may be nonlinearly unstable to the formation of compact ``localized states." The formation of space-filling patterns from…
In this paper, we conduct a thorough mathematical analysis of a tumor growth model with treatments. The model is a system describing the evolution of metastatic tumors and the number of cells present in a primary tumor. The former evolution…
In this paper, we characterize a degenerate PDE as the gradient flow in the space of nonnegative measures endowed with an optimal transport-growth metric. The PDE of concern, of Hele-Shaw type, was introduced by Perthame et. al. as a…
In recent years, there has been a spike in the interest in multi-phase tissue growth models. Depending on the type of tissue, the velocity is linked to the pressure through Stoke's law, Brinkman's law or Darcy's law. While each of these…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
This paper presents a mathematical framework for optimizing drug delivery in cancer treatment using a nonlocal model of solid tumor growth. We present a coupled system of partial differential equations that incorporate long-range cellular…
Spatial agent-based models are increasingly used to investigate the evolution of solid tumours subject to localised cell-cell interactions and microenvironmental heterogeneity. Here we present a non-technical step by step guide to…
We consider a fully practical finite element approximation of a diffuse interface model for tumour growth that takes the form of a degenerate parabolic system. In addition to showing stability bounds for the approximation, we prove…
Cancer is a very complex phenomenon that involves many different scales and situations. In this paper we consider a free boundary problem describing the evolution of a tumor colony and we derive a new asymptotic model for tumor growth. We…