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Monte Carlo (MC) simulation of linacs depends on the accurate geometrical description of the head. The geometry of the Varian TrueBeam (TB) linac is not available to researchers. Instead, the company distributes phase-space files (PSFs) of…

Quantitative theory of interbilayer interactions is essential to interpret x-ray scattering data and to elucidate these interactions for biologically relevant systems. For this purpose Monte Carlo simulations have been performed to obtain…

Biological Physics · Physics 2009-10-31 Nikolai Gouliaev , John F. Nagle

Scatter due to interaction of photons with the imaged object is a fundamental problem in X-ray Computed Tomography (CT). It manifests as various artifacts in the reconstruction, making its abatement or correction critical for image quality.…

Medical Physics · Physics 2024-01-30 Berk Iskender , Yoram Bresler

Purpose: The XCAT phantom allows for highly sophisticated multimodality imaging research. It includes a complete set of organs, muscle, bone, soft tissue, while also accounting for age, sex, and body mass index (BMI), which allows phantom…

We demonstrate dark-field x-ray microtomography in a compact, laboratory-based system capable of resolving attenuation, phase, and anisotropic scattering signals with micrometer-scale resolution across centimetre-scale samples. The method…

Computed tomography (CT) is a beneficial imaging tool for diagnostic purposes. CT scans provide detailed information concerning the internal anatomic structures of a patient, but present higher radiation dose and costs compared to X-ray…

Image and Video Processing · Electrical Eng. & Systems 2024-03-05 Benjamin Paulson , Joshua Goldshteyn , Sydney Balboni , John Cisler , Andrew Crisler , Natalia Bukowski , Julia Kalish , Theodore Colwell

We demonstrate computerized tomography (CT) reconstructions from absorption, phase and dark-field signals obtained from scans acquired when the x-ray probe light is modulated with speckle. Two different interlaced schemes are proposed to…

Optics · Physics 2016-04-27 Sebastien Berujon , Eric Ziegler

Pencil x-ray beam imaging provides superior spatial resolution than other imaging geometries like sheet beam and cone beam geometries due to the illumination of a line instead of an area or volume. However, the pencil beam geometry suffers…

Medical Physics · Physics 2021-02-01 Ignacio O. Romero , Changqing Li

We perform a detailed simulation of a pixelated CdTe detector using the GEANT4 toolkit completed with a custom code emulating the detector's electronic response. We demonstrate that a measured tungsten X-ray spectrum can be majorly restored…

Instrumentation and Detectors · Physics 2023-05-03 Andrii Tykhonov , Alexander Winkler , Volodymyr Smoliar

Recently, X-ray imaging dose from computed tomography (CT) or cone beam CT (CBCT) scans has become a serious concern. Patient-specific imaging dose calculation has been proposed for the purpose of dose management. While Monte Carlo (MC)…

Medical Physics · Physics 2015-05-30 Xun Jia , Hao Yan , Xuejun Gu , Steve B. Jiang

Knowledge gained through X-ray crystallography fostered structural determination of materials and greatly facilitated the development of modern science and technology in the past century. Atomic details of sample structures is achievable by…

Optics · Physics 2016-09-14 Hong Yu , Ronghua Lu , Shensheng Han , Honglan Xie , Guohao Du , Tiqiao Xiao , Daming Zhu

High-resolution x-ray tomography is a common technique for biomedical research using synchrotron sources. With advancements in laboratory x-ray sources, an increasing number of experiments can be performed in the lab. In this paper, the…

Instrumentation and Detectors · Physics 2024-08-23 Till Dreier , Robin Krüger , Gustaf Bernström , Karin Tran-Lundmark , Isabel Gonçalves , Martin Bech

It is discussed that the point spread function (PSF) of multiplexing parallel beam (MPB) is shift-invariant; the spatial resolution is linear as a function of depth h and the geometrical sensitivity is converged to a constant value at far…

Medical Physics · Physics 2013-11-20 Zhao Jing-Wu , Ma Jia-Yi , Shi Xiao-Dong

Computed Tomography serves as an indispensable tool in clinical workflows, providing non-invasive visualization of internal anatomical structures. Existing CT reconstruction works are limited to small-capacity model architecture and…

Image and Video Processing · Electrical Eng. & Systems 2025-05-27 Yifan Liu , Wuyang Li , Weihao Yu , Chenxin Li , Alexandre Alahi , Max Meng , Yixuan Yuan

Depth sectioning in reflection microscopy has predominantly relied on temporal coherence gating. Here we show that volumetric reflection tomography at diffraction-limited resolution can be achieved under monochromatic illumination by…

Focal plane X-ray polarimetry is intended for relatively bright sources with a negligible impact of background. However this might not be always possible for IXPE (Imaging X-ray Polarimetry Explorer) when observing faint extended sources…

Instrumentation and Methods for Astrophysics · Physics 2021-02-23 Fei Xie , Riccardo Ferrazzoli , Paolo Soffitta , Sergio Fabiani , Enrico Costa , Fabio Muleri , Alessandro Di Marco

Biophotonics is an active research area in molecular imaging, genetic diagnosis and prognosis, with direct applicability in precision medicine. However, long-standing challenges of biophotonics are well known due to low signal-to-noise…

Medical Physics · Physics 2017-10-02 Michael C Lun , Wei Zhang , Yue Zhao , Jeffrey Anker , Wenxiang Cong , Ge Wang , Changqing Li

Computed tomography (CT) is widely used in scientific imaging systems such as synchrotron and laboratory-based nano-CT, but acquiring full-view sinograms requires high radiation dose and long scan times. Sparse-view CT reduces this burden…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Jiaze E , Srutarshi Banerjee , Tekin Bicer , Guannan Wang , Yanfu Zhang , Bin Ren

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

Optics · Physics 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

In Single Photon Emission Computed Tomography (SPECT), 3D images usually reconstructed by performing a set of bidimensional (2D) analytical or iterative reconstructions can also be reconstructed using an iterative reconstruction algorithm…

Instrumentation and Detectors · Physics 2007-05-23 Z. El Bitar , I. Buvat , V. Breton , D. Lazaro , D. Hill