Related papers: Inertial migration and axial control of deformable…
Cells and other soft particles are often forced to flow in confined geometries in both laboratory and natural environments, where the elastic deformation induces an additional drag and pressure drop across the particle. In contrast with…
Microchannels are well-known in microfluidic applications for the control and separation of microdroplets and cells. Often the objects in the flow experience inertial effects, resulting in dynamics that is a departure from the underlying…
Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…
Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a…
Inspired by numerous lab on a chip, biomedical and bioengineering applications such as cell sorting, focusing, trapping, and filtering of particles, manipulation of micron sized particle trajectories has been of significant interest in the…
Cell stiffness is a key determinant of how cells deform, migrate, and adapt to mechanically restrictive environments, yet existing single-cell stiffness assays remain difficult to combine with molecular analysis and downstream functional…
Long, shallow microchannels embedded in thick soft materials are widely used in microfluidic devices for lab-on-a-chip applications. However, the bulging effect caused by fluid--structure interactions between the internal viscous flow and…
We discuss an inertial migration of oblate spheroids in a plane channel, where steady laminar flow is generated by a pressure gradient. Our lattice Boltzmann simulations show that spheroids orient in the flow, so that their minor axis…
Constructing physical models of living cells and tissues is an extremely challenging task because of the high complexities of both intra- and intercellular processes. In addition, the force that a single cell generates vanishes in total due…
In this paper, the effectiveness of electromagnetic forces on controlling the motion of a sedimenting elliptical particle is investigated using the immersed interface-lattice Boltzmann method (II-LBM), in which a signed distance function is…
The directed migration of cells toward stiffer substrate regions or durotaxis is relevant to tissue development and tumor progression. Here, we introduce a phenomenological model for single cell durotaxis that incorporates both elastic…
The irreversible behavior of a highly confined non-Brownian suspension of spherical particles at low Reynolds number in a Newtonian fluid is studied experimentally and numerically. In experiment, the suspension is confined in a thin…
Using air to displace a viscous fluid contained in Hele-Shaw cell can create a fingering pattern at the interface between the fluids, if the capillary number exceeds a critical value. This Saffman-Taylor instability is revisited for the…
The imbalance of normal stress around a particle induces its transverse migration in pressure-driven viscoelastic flow, offering possibilities for particle manipulation in microfluidic devices. Theoretical predictions align with…
The buoyancy-driven motion of a deformable bubble rising near a vertical hydrophilic wall is studied numerically. We focus on moderately inertial regimes in which the bubble undergoes low-to-moderate deformations and would rise in a…
This study examines the motion of spherical inertial particles in a three-dimensional rotating cylindrical vortex - a simplified model of geophysical flow structures such as oceanic eddies. The analytical vortex formulation enables the…
When transported in confined geometries rigid fibers show interesting transport dynamics induced by friction with the top and bottom walls. Fiber flexibility causes an additional coupling between fiber deformation and transport and is…
Substrate-based cell motility is essential for fundamental biological processes, such as tissue growth, wound healing and immune response. Even if a comprehensive understanding of this motility mode remains elusive, progress has been…
Liquid capillary-bridge formation between solid particles has a critical influence on the rheological properties of granular materials and, in particular, on the efficiency of fluidized bed reactors. The available analytical and…
Finite-size neutrally buoyant particles in a channel flow are known to accumulate at specific equilibrium positions or spots in the channel cross-section if the flow inertia is finite at the particle scale. Experiments in different conduit…