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The characterization of drug-protein interactions is crucial in the high-throughput screening for drug discovery. The deep learning-based approaches have attracted attention because they can predict drug-protein interactions without…

Machine Learning · Computer Science 2020-12-22 QHwan Kim , Joon-Hyuk Ko , Sunghoon Kim , Nojun Park , Wonho Jhe

Deep Neural networks are efficient and flexible models that perform well for a variety of tasks such as image, speech recognition and natural language understanding. In particular, convolutional neural networks (CNN) generate a keen…

Machine Learning · Computer Science 2018-12-20 Yesmina Jaafra , Jean Luc Laurent , Aline Deruyver , Mohamed Saber Naceur

Standard deep neural networks (DNNs) are commonly trained in an end-to-end fashion for specific tasks such as object recognition, face identification, or character recognition, among many examples. This specificity often leads to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Raphaël Achddou , J. Matias di Martino , Guillermo Sapiro

In the field of deep learning, the prevalence of models initially trained with 32-bit precision is a testament to its robustness and accuracy. However, the continuous evolution of these models often demands further training, which can be…

Machine Learning · Computer Science 2023-12-04 Juyoung Yun

In this work, we investigate the value of employing deep learning for the task of wireless signal modulation recognition. Recently in [1], a framework has been introduced by generating a dataset using GNU radio that mimics the imperfections…

Machine Learning · Computer Science 2018-01-08 Xiaoyu Liu , Diyu Yang , Aly El Gamal

The field of RNA secondary structure prediction has made significant progress with the adoption of deep learning techniques. In this work, we present the RNAformer, a lean deep learning model using axial attention and recycling in the…

Machine Learning · Computer Science 2023-07-20 Jörg K. H. Franke , Frederic Runge , Frank Hutter

Predicting the structure of multi-protein complexes is a grand challenge in biochemistry, with major implications for basic science and drug discovery. Computational structure prediction methods generally leverage pre-defined structural…

Biomolecules · Quantitative Biology 2021-01-26 Stephan Eismann , Raphael J. L. Townshend , Nathaniel Thomas , Milind Jagota , Bowen Jing , Ron O. Dror

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

Current state-of-the-art speech recognition systems build on recurrent neural networks for acoustic and/or language modeling, and rely on feature extraction pipelines to extract mel-filterbanks or cepstral coefficients. In this paper we…

Computation and Language · Computer Science 2019-04-10 Neil Zeghidour , Qiantong Xu , Vitaliy Liptchinsky , Nicolas Usunier , Gabriel Synnaeve , Ronan Collobert

Structured prediction tasks pose a fundamental trade-off between the need for model complexity to increase predictive power and the limited computational resources for inference in the exponentially-sized output spaces such models require.…

Machine Learning · Statistics 2012-08-17 David Weiss , Benjamin Sapp , Ben Taskar

Convolution Neural Networks (CNN) have been extremely successful in solving intensive computer vision tasks. The convolutional filters used in CNNs have played a major role in this success, by extracting useful features from the inputs.…

Computer Vision and Pattern Recognition · Computer Science 2020-01-08 Pravendra Singh , Pratik Mazumder , Vinay P. Namboodiri

Convolutional neural networks rely on image texture and structure to serve as discriminative features to classify the image content. Image enhancement techniques can be used as preprocessing steps to help improve the overall image quality…

Computer Vision and Pattern Recognition · Computer Science 2018-03-30 Vivek Sharma , Ali Diba , Davy Neven , Michael S. Brown , Luc Van Gool , Rainer Stiefelhagen

Query performance prediction, the task of predicting the latency of a query, is one of the most challenging problem in database management systems. Existing approaches rely on features and performance models engineered by human experts, but…

Databases · Computer Science 2020-04-09 Ryan Marcus , Olga Papaemmanouil

The generation of protein crystals is necessary for the study of protein molecular function and structure. This is done empirically by processing large numbers of crystallization trials and inspecting them regularly in search of those with…

Computer Vision and Pattern Recognition · Computer Science 2018-05-15 Soheil Ghafurian , Peter Orth , Corey Strickland , Hua Su , Sangita Patel , Steven Soisson , Belma Dogdas

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray

Over the past decade, Deep Convolutional Neural Networks (DCNNs) have shown remarkable performance in most computer vision tasks. These tasks traditionally use a fixed dataset, and the model, once trained, is deployed as is. Adding new…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Deboleena Roy , Priyadarshini Panda , Kaushik Roy

Given native 2D contact map, protein 3D structure could be reconstructed with accuracy of 2A or better, and such reconstruction is a feasible computational approach for protein folding problem. The prediction accuracy from traditional…

Biomolecules · Quantitative Biology 2019-06-12 Yuhong Wang , Wei Li , Hongmao Sun , Kennie Cruz-Gutierrez

Deep Convolutional Neural Networks (CNNs) have been widely used in various domains due to their impressive capabilities. These models are typically composed of a large number of 2D convolutional (Conv2D) layers with numerous trainable…

Machine Learning · Computer Science 2022-02-01 Yinan Yu , Samuel Scheidegger , Tomas McKelvey

In the context of classification problems, Deep Learning (DL) approaches represent state of art. Many DL approaches are based on variations of standard multi-layer feed-forward neural networks. These are also referred to as deep networks.…

Machine Learning · Computer Science 2023-11-21 Andrea Apicella , Francesco Isgrò , Roberto Prevete

In recent years, convolutional neural networks (CNNs) have shown great performance in various fields such as image classification, pattern recognition, and multi-media compression. Two of the feature properties, local connectivity and…

Machine Learning · Computer Science 2018-07-24 Qianru Zhang , Meng Zhang , Tinghuan Chen , Zhifei Sun , Yuzhe Ma , Bei Yu