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Cells generally convert nutrient resources to useful products via energy transduction. Accordingly, the thermodynamic efficiency of this conversion process is one of the most essential characteristics of living organisms. However, although…

Biological Physics · Physics 2016-05-04 Yusuke Himeoka , Kunihiko Kaneko

A complete mathematical theory of nonequilibrium thermodynamics of stochastic systems in terms of master equations is presented. As generalizations of isothermal entropy and free energy, two functions of states play central roles: the Gibbs…

Statistical Mechanics · Physics 2010-05-28 Hao Ge , Hong Qian

Routinely navigating through an ever-changing and unsteady environment, and utilizing chemical energy, molecular motors transport the cell's crucial components, such as neurotransmitters and organelles. They generate force and pull cargo,…

Biological Physics · Physics 2012-09-28 Bartosz Lisowski , Michał Żabicki

The dynamics of folding of proteins is studied by means of a phenomenological master equation. The energy distribution is taken as a truncated exponential for the misfolded states plus a native state sitting below the continuum. The…

Soft Condensed Matter · Physics 2007-05-23 Estelle Pitard , Henri Orland

We devise automated workflows for the calculation of Helmholtz and Gibbs free energies and their temperature and pressure dependence and provide the corresponding computational tools. We employ non-equilibrium thermodynamics for evaluating…

Materials Science · Physics 2021-10-13 Sarath Menon , Yury Lysogorskiy , Jutta Rogal , Ralf Drautz

In this study we reproduced this compression-induced reduction in muscle force through the use of a three-dimensional finite element model of contracting muscle. The model used the principle of minimum total energy and allowed for the…

Tissues and Organs · Quantitative Biology 2021-01-13 D. S. Ryan , S. Domínguez , S. A. Ross , N. Nigam , J. M. Wakeling

Protein machines often exhibit long range interplay between different sites in order to achieve their biological tasks. We investigate and characterize the non--linear energy localization and the basic mechanisms of energy transfer in…

Biological Physics · Physics 2015-12-14 M. Caraglio , A. Imparato

The neuron consumes energy from ATP hydrolysis to maintain a far-from-equilibrium steady state inside the cell, thus all physiological functions inside the cell are modulated by thermodynamics. The neurons that manage information encoding,…

Neurons and Cognition · Quantitative Biology 2024-12-03 Jianwei Li , Simeng Yu , Mingye Guo , Xuewen Shen , Qi Ouyang , Fangting Li

We propose a concept of autonomous energy transducer at a molecular scale, where output is produced with small input energy, of the same order of the thermal energy, without restriction of magnitude or timing of input, and without any…

Condensed Matter · Physics 2016-08-31 Naoko Nakagawa , Kunihiko Kaneko

Protein conformational changes are activated processes essential for protein functions. Activation in a protein differs from activation in a small molecule in that it involves directed and systematic energy flows through preferred channels…

Biological Physics · Physics 2020-07-15 Huiyu Li , Ao Ma

Water plays a fundamental role in protein stability. However, the effect of the properties of water on the behaviour of proteins is only partially understood. Several theories have been proposed to give insight into the mechanisms of cold…

Soft Condensed Matter · Physics 2021-03-25 Giancarlo Franzese , Joan Àguila Rojas , Valentino Bianco , Ivan Coluzza

Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of…

Molecular Networks · Quantitative Biology 2023-08-07 Valérie Voorsluijs , Francesco Avanzini , Gianmaria Falasco , Massimiliano Esposito , Alexander Skupin

Dietary assessment is essential to maintaining a healthy lifestyle. Automatic image-based dietary assessment is a growing field of research due to the increasing prevalence of image capturing devices (e.g. mobile phones). In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2023-09-25 Jack Ma , Jiangpeng He , Fengqing Zhu

Conversion of corn to ethanol in the US since 2005 has been a major cause of global food price increases during that time and has been shown to be ineffective in achieving US energy independence and reducing environmental impact. We make…

General Finance · Quantitative Finance 2012-10-24 Dominic K. Albino , Karla Z. Bertrand , Yaneer Bar-Yam

Molecular motors transduce chemical energy obtained from hydrolizing ATP into mechanical work exerted against an external force. We calculate their efficiency at maximum power output for two simple generic models and show that the…

Statistical Mechanics · Physics 2009-11-13 Tim Schmiedl , Udo Seifert

The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the…

Biomolecules · Quantitative Biology 2015-06-04 Stefan Ernst , Monika G. Dueser , Nawid Zarrabi , Michael Boersch

The process of evolution by natural selection leads to phenotypes of increasing fitness. For cellular chemical reaction networks, this means optimising a variety of fitness functions such as robustness, precision, or sensitivity to external…

Soft Condensed Matter · Physics 2026-02-16 Tanja Schilling , Patrick B. Warren , Wilson Poon

ATPases cyclically convert chemical energy in the form of ATP gradients into directed motion inside cells. To function, ATPases rely on allosteric communication between at least two binding sites, an internal signaling mechanism that is not…

Molecular Networks · Quantitative Biology 2025-12-22 Tosan Omabegho

A quantum theory on conformation-electron system is presented. Protein folding is regarded as the quantum transition between torsion states on polypeptide chain, and the folding rate is calculated by nonadiabatic operator method. The theory…

Biomolecules · Quantitative Biology 2011-02-21 Liaofu Luo , Jun Lu

Motor enzymes catalyze chemical reactions, like the hydrolysis of ATP, and in the process they also perform work. Recent studies indicate that motor enzymes perform work with specific intermediate steps in their catalyzed reactions,…

Biological Physics · Physics 2007-05-23 Josh E. Baker