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In the theory of special relativity, energy can be found in two forms: kinetic energy and rest mass. Potential energy of a body is actually stored under the form of rest mass, interaction energy too, temperature is not. Information acquired…

General Physics · Physics 2024-04-17 D. Lairez

A simple and effective approach to thermodynamics is suggested, which solves the major difficulties in the traditional presentation of the subject. The internal energy is introduced from the behavior of deformable bodies, whereas the…

General Physics · Physics 2012-03-13 Rodrigo de Abreu , Vasco Guerra

ATP synthase's intrinsic molecular electrostatic potential (MESP) adds constructively to, and hence reinforces, the chemiosmotic voltage. This ATP synthase voltage represents a new free energy term that appears to have been overlooked. This…

The diffusion of a molecular motor in the presence of a constant external force is considered on the basis of a simple theoretical model. The motor is represented by a Brownian particle moving in a series of parabolic potentials placed…

Statistical Mechanics · Physics 2016-06-01 Ryota Shinagawa , Kazuo Sasaki

The received wisdom on how activity affects energy expenditure is that the more activity is undertaken, the more calories will have been burned by the end of the day. Yet traditional hunter-gatherers, who lead physically hard lives, burn no…

Other Quantitative Biology · Quantitative Biology 2021-07-29 Lewis G. Halsey

The cytoskeletal component actomyosin is a canonical example of active matter since the powerstroke cycle locally converts chemical energy in the form of adenoside triphosphate (ATP) into mechanical work for remodelling. Observing myosin II…

Biological Physics · Physics 2024-12-05 Sami C. Al-Izzi , Sedigheh Ghanbarzadeh Nodehi , Darius V. Köster , Richard G. Morris

The thermosynthesis concept, biological free energy gain from thermal cycling, is combined with the concept of the RNA World. The resulting overall origin of life model gives new explanations for the emergence of the genetic code and the…

Populations and Evolution · Quantitative Biology 2007-05-23 Anthonie W. J. Muller

Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

Free energy and entropy are examined in detail from the standpoint of classical thermodynamics. The approach is logically based on the fact that thermodynamic work is mediated by thermal energy through the tendency for nonthermal energy to…

Physics Education · Physics 2015-06-26 Clinton D. Stoner

In pancreatic $\beta$-cells, calcium oscillation signal is the core part of glucose-stimulated insulin secretion. Intracellular calcium concentration oscillates in response to the intake of glucose, which triggers the exocytosis of insulin…

Cell Behavior · Quantitative Biology 2018-11-30 Yunsheng Sun , Congjian Ni , Yingda Ge , Hong Qian , Qi Ouyang , Fangting Li

The excess work required to drive a stochastic system out of thermodynamic equilibrium through a time-dependent external perturbation is directly related to the amount of entropy produced during the driving process, allowing excess work and…

Statistical Mechanics · Physics 2021-03-15 Steven J Large , Jannik Ehrich , David A Sivak

To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed…

Tissues and Organs · Quantitative Biology 2019-11-07 Benoit Viollet

The overall process of photosynthesis consists of two main phases, the so-called light and dark eactions: light energy is absorbed by chlorophyll molecules and transferred to regenerate NADH and ATP, then drive Calvin-Benson cycle to…

Chemical Physics · Physics 2010-09-03 Weidong Huang

Mismatch repair is a critical step in DNA replication that occurs after base selection and proofreading, significantly increasing fidelity. However, the mechanism of mismatch recognition has not been established for any repair enzyme.…

Biological Physics · Physics 2024-04-09 Nianqin Zhang , Yongjun Zhang

Cells generally convert external nutrient resources to support metabolismand growth. Understanding the thermodynamic efficiency of this conversion is essential to determine the general characteristics of cellular growth. Using a simple…

Subcellular Processes · Quantitative Biology 2015-06-19 Yusuke Himeoka , Kunihiko Kaneko

Molecular motors fulfill critical functions within all living beings. Understanding their underlying working principles is therefore of great interest. Here we develop a simple model inspired by the two-component biomolecular motor Fo-F1…

Statistical Mechanics · Physics 2024-12-30 Mathis Grelier , David A. Sivak , Jannik Ehrich

Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids. Thus, removing access to glucose has the potential to starve…

Other Quantitative Biology · Quantitative Biology 2021-06-01 Adam Kapelner , Matthew Vorsanger

In this paper we report, clarify and broaden various recent efforts to complement the chemistry-centered models of force generation in muscles by mechanics-centered models. The physical mechanisms of interest can be grouped into two…

Biological Physics · Physics 2018-06-26 Matthieu Caruel , Lev Truskinovsky

It is argued that a typical many body energy eigenstate has a well defined thermodynamic entropy and that individual eigenstates possess thermodynamic characteristics analogous to those of generic isolated systems. We examine large systems…

Statistical Mechanics · Physics 2015-05-14 J. M. Deutsch

The peristaltic motion of the stomach walls combines with the secretion of enzymes to initiate the process that breaks down food. Computational modelling of this phenomenon can help reveal the details that would be hard to capture via…

Fluid Dynamics · Physics 2026-05-12 Sharun Kuhar , Jae Ho Lee , Jung-Hee Seo , Pankaj J Pasricha , Rajat Mittal