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Related papers: Drug-Drug Interaction Extraction from Biomedical T…

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Joint entity-relation extraction is a critical task in transforming unstructured or semi-structured text into triplets, facilitating the construction of large-scale knowledge graphs, and supporting various downstream applications. Despite…

Computation and Language · Computer Science 2025-02-14 Danni Feng , Runzhi Li , Jing Wang , Siyu Yan , Lihong Ma , Yunli Xing

Recent studies suggest that drug-drug interaction (DDI) prediction via computational approaches has significant importance for understanding the functions and co-prescriptions of multiple drugs. However, the existing silico DDI prediction…

Molecular Networks · Quantitative Biology 2024-08-29 Changjian Zhou , Xin Zhang , Jiafeng Li , Jia Song , Wensheng Xiang

Drug-drug interactions (DDI) can cause severe adverse drug reactions and pose a major challenge to medication therapy. Recently, informatics-based approaches are emerging for DDI studies. In this paper, we aim to identify key…

Quantitative Methods · Quantitative Biology 2019-12-09 Jianyuan Deng , Fusheng Wang

The extraction of biomedical data has significant academic and practical value in contemporary biomedical sciences. In recent years, drug repositioning, a cost-effective strategy for drug development by discovering new indications for…

Machine Learning · Computer Science 2025-01-20 Enqiang Zhu , Xiang Li , Chanjuan Liu , Nikhil R. Pal

Over the years several studies have demonstrated the ability to identify potential drug-drug interactions via data mining from the literature (MEDLINE), electronic health records, public databases (Drugbank), etc. While each one of these…

Computers and Society · Computer Science 2015-07-21 Juan M. Banda , Tobias Kuhn , Nigam H. Shah , Michel Dumontier

Long-Short-Term-Memory (LSTM) networks have shown great promise in artificial intelligence (AI) based language modeling. Recently, LSTM networks have also become popular for designing AI-based Intrusion Detection Systems (IDS). However, its…

Cryptography and Security · Computer Science 2021-09-24 Mohit Sewak , Sanjay K. Sahay , Hemant Rathore

Monitoring the administration of drugs and adverse drug reactions are key parts of pharmacovigilance. In this paper, we explore the extraction of drug mentions and drug-related information (reason for taking a drug, route, frequency,…

Computation and Language · Computer Science 2019-09-24 Maksim Belousov , Nikola Milosevic , Ghada Alfattni , Haifa Alrdahi , Goran Nenadic

Detecting probable Drug Target Interaction (DTI) is a critical task in drug discovery. Conventional DTI studies are expensive, labor-intensive, and take a lot of time, hence there are significant reasons to construct useful computational…

Quantitative Methods · Quantitative Biology 2022-10-24 Tanya Liyaqat , Tanvir Ahmad , Chandni Saxena

Individual's general well-being is greatly impacted by mental health conditions including depression and Post-Traumatic Stress Disorder (PTSD), underscoring the importance of early detection and precise diagnosis in order to facilitate…

Machine Learning · Computer Science 2025-02-07 Himanshi Singh , Sadhana Tiwari , Sonali Agarwal , Ritesh Chandra , Sanjay Kumar Sonbhadra , Vrijendra Singh

Accurate prediction of drug-target interactions (DTI) is pivotal for drug discovery, yet existing methods often fail to address challenges like cross-domain generalization, cold-start prediction, and interpretability. In this work, we…

Multimedia · Computer Science 2025-10-23 Xiangyu Li , Haojie Yang , Kaimiao Hu , Runzhi Wu , Liangliang Liu , Ran Su

Drug-target relationships may now be predicted computationally using bioinformatics data, which is a valuable tool for understanding pharmacological effects, enhancing drug development efficiency, and advancing related research. A number of…

Machine Learning · Computer Science 2024-07-16 Yuhuan Zhou , Yulin Wu , Weiwei Yuan , Xuan Wang , Junyi Li

Accurate prediction of drug-drug interactions (DDI) is crucial for medication safety and effective drug development. However, existing methods often struggle to capture structural information across different scales, from local functional…

Machine Learning · Computer Science 2026-03-27 Zimo Yan , Jie Zhang , Zheng Xie , Yiping Song , Hao Li

Automatically extracting the relationships between chemicals and diseases is significantly important to various areas of biomedical research and health care. Biomedical experts have built many large-scale knowledge bases (KBs) to advance…

Computation and Language · Computer Science 2019-12-24 Huiwei Zhou , Yunlong Yang , Shixian Ning , Zhuang Liu , Chengkun Lang , Yingyu Lin , Degen Huang

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

Computation and Language · Computer Science 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin

Bidirectional long short-term memory (bi-LSTM) networks have recently proven successful for various NLP sequence modeling tasks, but little is known about their reliance to input representations, target languages, data set size, and label…

Computation and Language · Computer Science 2016-07-22 Barbara Plank , Anders Søgaard , Yoav Goldberg

Most existing methods for predicting drug-drug interactions (DDI) predominantly concentrate on capturing the explicit relationships among drugs, overlooking the valuable implicit correlations present between drug pairs (DPs), which leads to…

Machine Learning · Computer Science 2024-02-29 Mengying Jiang , Guizhong Liu , Yuanchao Su , Weiqiang Jin , Biao Zhao

Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested to improve learning and…

Neurons and Cognition · Quantitative Biology 2020-10-22 Paul Smolen , Douglas A Baxter , John H Byrne

Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used…

Quantitative Methods · Quantitative Biology 2018-08-10 Mahtab Ahmed , Jumayel Islam , Muhammad Rifayat Samee , Robert E. Mercer

Drug-target interaction (DTI) prediction is a challenging, albeit essential task in drug repurposing. Learning on graph models have drawn special attention as they can significantly reduce drug repurposing costs and time commitment.…

Thanks to the increasing availability of drug-drug interactions (DDI) datasets and large biomedical knowledge graphs (KGs), accurate detection of adverse DDI using machine learning models becomes possible. However, it remains largely an…

Machine Learning · Computer Science 2021-05-10 Yue Yu , Kexin Huang , Chao Zhang , Lucas M. Glass , Jimeng Sun , Cao Xiao
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