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The tremdendous advances in high-throughput sequencing technologies have made population-scale sequencing as performed in the 1000 Genomes project and the Genome of the Netherlands project possible. Next-generation sequencing has allowed…

Genomics · Quantitative Biology 2013-03-15 Tobias Marschall , Alexander Schönhuth

Weakly Supervised Semantic Segmentation (WSSS) research has explored many directions to improve the typical pipeline CNN plus class activation maps (CAM) plus refinements, given the image-class label as the only supervision. Though the gap…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Simone Rossetti , Damiano Zappia , Marta Sanzari , Marco Schaerf , Fiora Pirri

Physics-informed neural networks (PINN) face significant challenges from spectral bias, which impedes their ability to model high-frequency phenomena and limits extrapolation performance. To address this, we introduce xLSTM-PINN, a novel…

Machine Learning · Computer Science 2025-12-08 Ze Tao , Darui Zhao , Fujun Liu , Ke Xu , Xiangsheng Hu

Background: Identifying all possible mapping locations of next-generation sequencing (NGS) reads is highly essential in several applications such as prediction of genomic variants or protein binding motifs located in repeat regions, isoform…

Genomics · Quantitative Biology 2020-03-25 Ngoc Hieu Tran , Xin Chen

Deep networks are increasingly being applied to problems involving image synthesis, e.g., generating images from textual descriptions and reconstructing an input image from a compact representation. Supervised training of image-synthesis…

Machine Learning · Computer Science 2017-01-25 Jake Snell , Karl Ridgeway , Renjie Liao , Brett D. Roads , Michael C. Mozer , Richard S. Zemel

Traditional Von Neumann computing is falling apart in the era of exploding data volumes as the overhead of data transfer becomes forbidding. Instead, it is more energy-efficient to fuse compute capability with memory where the data reside.…

We introduce PINGS (Physics-Informed Neural Network for Fast Generative Sampling), a framework that amortizes diffusion sampling by training a physics-informed network to approximate reverse-time probability-flow dynamics, reducing sampling…

Recent studies have used deep residual convolutional neural networks (CNNs) for JPEG compression artifact reduction. This study proposes a scalable CNN called S-Net. Our approach effectively adjusts the network scale dynamically in a…

Computer Vision and Pattern Recognition · Computer Science 2019-07-24 Bolun Zheng , Rui Sun , Xiang Tian , Yaowu Chen

Motivation: Protein-to-genome alignment is critical to annotating genes in non-model organisms. While there are a few tools for this purpose, all of them were developed over ten years ago and did not incorporate the latest advances in…

Genomics · Quantitative Biology 2022-12-29 Heng Li

Pattern search is crucial in numerous analytic applications for retrieving data entries akin to the query. Content Addressable Memories (CAMs), an in-memory computing fabric, directly compare input queries with stored entries through…

Emerging Technologies · Computer Science 2025-02-11 Chenyu Ni , Sijie Chen , Che-Kai Liu , Liu Liu , Mohsen Imani , Thomas Kampfe , Kai Ni , Michael Niemier , Xiaobo Sharon Hu , Cheng Zhuo , Xunzhao Yin

We propose a method for lossy image compression based on recurrent, convolutional neural networks that outperforms BPG (4:2:0 ), WebP, JPEG2000, and JPEG as measured by MS-SSIM. We introduce three improvements over previous research that…

Computer Vision and Pattern Recognition · Computer Science 2017-03-30 Nick Johnston , Damien Vincent , David Minnen , Michele Covell , Saurabh Singh , Troy Chinen , Sung Jin Hwang , Joel Shor , George Toderici

Modern parallel computing devices, such as the graphics processing unit (GPU), have gained significant traction in scientific and statistical computing. They are particularly well-suited to data-parallel algorithms such as the particle…

Computation · Statistics 2015-06-12 Lawrence M. Murray , Anthony Lee , Pierre E. Jacob

Sequence-based protein homology detection has been extensively studied and so far the most sensitive method is based upon comparison of protein sequence profiles, which are derived from multiple sequence alignment (MSA) of sequence homologs…

Quantitative Methods · Quantitative Biology 2015-06-18 Jianzhu Ma , Sheng Wang , Zhiyong Wang , Jinbo Xu

In-memory database query processing frequently involves substantial data transfers between the CPU and memory, leading to inefficiencies due to Von Neumann bottleneck. Processing-in-Memory (PIM) architectures offer a viable solution to…

Although deep learning-based personalized recommendation systems provide qualified recommendations, they strain data center resources. The main bottleneck is the embedding layer, which is highly memory-intensive due to its sparse, irregular…

Hardware Architecture · Computer Science 2025-11-26 Youngsuk Kim , Junghwan Lim , Hyuk-Jae Lee , Chae Eun Rhee

We introduce PRISM (Predictive Reasoning in Sequential Medicine), a transformer-based architecture designed to model the sequential progression of clinical decision-making processes. Unlike traditional approaches that rely on isolated…

Computation and Language · Computer Science 2025-06-16 Lionel Levine , John Santerre , Alex S. Young , T. Barry Levine , Francis Campion , Majid Sarrafzadeh

Recent works demonstrated the promise of using resistive random access memory (ReRAM) as an emerging technology to perform inherently parallel analog domain in-situ matrix-vector multiplication -- the intensive and key computation in DNNs.…

Hardware Architecture · Computer Science 2021-06-18 Geng Yuan , Payman Behnam , Zhengang Li , Ali Shafiee , Sheng Lin , Xiaolong Ma , Hang Liu , Xuehai Qian , Mahdi Nazm Bojnordi , Yanzhi Wang , Caiwen Ding

Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms. We describe a…

Genomics · Quantitative Biology 2009-11-02 Aaron E. Darling , Bob Mau , Nicole T. Perna

In this paper, we propose a novel framework for speech-image retrieval. We utilize speech-image contrastive (SIC) learning tasks to align speech and image representations at a coarse level and speech-image matching (SIM) learning tasks to…

Computation and Language · Computer Science 2024-09-12 Lifeng Zhou , Yuke Li

Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS). Most approaches currently used to store HTS data are either unable to…

Quantitative Methods · Quantitative Biology 2014-03-05 Fabien Campagne , Kevin C. Dorff , Nyasha Chambwe , James T. Robinson , Jill P. Mesirov , Thomas D. Wu