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Molecular docking, which aims to find the most stable interacting configuration of a set of molecules, is of critical importance to drug discovery. Although a considerable number of classical algorithms have been developed to carry out…

Biomolecules · Quantitative Biology 2022-10-21 Mohit Pandey , Tristan Zaborniak , Hans Melo , Alexey Galda , Vikram K. Mulligan

Quantum annealing has great promise in leveraging quantum mechanics to solve combinatorial optimisation problems. However, to realize this promise to it's fullest extent we must appropriately leverage the underlying physics. In this spirit,…

Quantum Physics · Physics 2020-12-10 Nicholas Chancellor

We develop a hybrid type of quantum annealing in which we control temperature and quantum field simultaneously. We study the efficiency of proposed quantum annealing and find a good schedule of changing thermal fluctuation and quantum…

Disordered Systems and Neural Networks · Physics 2015-03-19 Shu Tanaka , Ryo Tamura , Issei Sato , Kenichi Kurihara

Node embedding is a key technique for representing graph nodes as vectors while preserving structural and relational properties, which enables machine learning tasks like feature extraction, clustering, and classification. While classical…

Quantum Physics · Physics 2025-03-11 Hristo N. Djidjev

A major limitation of current generations of quantum annealers is the sparse connectivity of manufactured qubits in the hardware graph. This technological limitation generated considerable interest, motivating efforts to design efficient…

Large quantum computers promise to solve some critical problems not solvable otherwise. However, modern quantum technologies suffer various imperfections such as control errors and qubit decoherence, inhibiting their potential utility. The…

Quantum Physics · Physics 2023-01-19 Andrii Maksymov , Jason Nguyen , Yunseong Nam , Igor Markov

Quantum machine learning has the potential to enable advances in artificial intelligence, such as solving problems intractable on classical computers. Some fundamental ideas behind quantum machine learning are similar to kernel methods in…

Quantum Physics · Physics 2023-08-15 Samuel Bosch , Bobak Kiani , Rui Yang , Adrian Lupascu , Seth Lloyd

Predicting software defects early in the development process not only enhances the quality and reliability of the software but also decreases the cost of development. A wide range of machine learning techniques can be employed to create…

Software Engineering · Computer Science 2024-10-23 Ashis Kumar Mandal , Md Nadim , Chanchal K. Roy , Banani Roy , Kevin A. Schneider

Quantum computing will change the way we tackle certain problems. It promises to dramatically speed-up many chemical, financial, and machine-learning applications. However, to capitalize on those promises, complex design flows composed of…

Quantum Physics · Physics 2020-10-28 Lukas Burgholzer , Robert Wille

Quantum computers face inherent scaling challenges, a fact that necessitates investigation of distributed quantum computing systems, whereby scaling is achieved through interconnection of smaller quantum processing units. However,…

Quantum Physics · Physics 2026-01-21 Felix Burt , Kuan-Cheng Chen , Kin K. Leung

Quenching and annealing are extreme opposites in the time evolution of a quantum system: Annealing explores equilibrium phases of a Hamiltonian with slowly changing parameters and can be exploited as a tool for solving complex optimization…

Quantum Physics · Physics 2022-01-19 Bernhard Irsigler , Tobias Grass

Quantum Machine Learning (QML) holds the promise of enhancing machine learning modeling in terms of both complexity and accuracy. A key challenge in this domain is the encoding of input data, which plays a pivotal role in determining the…

Quantum hardware has the potential to efficiently solve computationally difficult problems in physics and chemistry to reap enormous practical rewards. Analogue quantum simulation accomplishes this by using the dynamics of a controlled…

Traditional simulated annealing utilizes thermal fluctuations for convergence in optimization problems. Quantum tunneling provides a different mechanism for moving between states, with the potential for reduced time scales. We compare…

Condensed Matter · Physics 2007-05-23 J. Brooke , D. Bitko , T. F. Rosenbaum , G. Aeppli

We demonstrate how quantum field theory problems can be embedded on quantum annealers. The general method we use is a discretisation of the field theory problem into a general Ising model, with the continuous field values being encoded into…

High Energy Physics - Phenomenology · Physics 2021-01-20 Steven Abel , Nicholas Chancellor , Michael Spannowsky

In this paper we present a novel strategy to solve optimization problems within a hybrid quantum-classical scheme based on quantum annealing, with a particular focus on QUBO problems. The proposed algorithm is based on an iterative…

Quantum Physics · Physics 2020-04-07 Enrico Blanzieri , Davide Pastorello

Stochastic Unit Commitment (SUC) has been proposed to manage the uncertainties driven by renewable integration, but it leads to significant computational complexity. When accelerated by Benders Decomposition (BD), the master problem becomes…

Quantum Physics · Physics 2026-02-25 Wei Hong , Wangkun Xu , Fei Teng

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

We develop and apply several strategies for setting physical parameters on quantum annealers for application problems that do not fit natively on the hardware graph. The strategies are tested with a culled random set of mixed satisfiability…

Quantum Physics · Physics 2016-11-24 Kristen L. Pudenz

Quantum annealing aims at finding optimal solutions to complex optimization problems using a suitable quantum many body Hamiltonian encoding the solution in its ground state. To find the solution one typically evolves the ground state of a…

Quantum Physics · Physics 2022-05-13 Elias Starchl , Helmut Ritsch