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High throughput sequencing (HTS)-based technology enables identifying and quantifying non-culturable microbial organisms in all environments. Microbial sequences have enhanced our understanding of the human microbiome, the soil and plant…

Applications · Statistics 2021-03-09 Pratheepa Jeganathan , Susan P. Holmes

We have developed a methodology for the systematic generation of a large image dataset of macerated wood references, which we used to generate image data for nine hardwood genera. This is the basis for a substantial approach to automate,…

Computer Vision and Pattern Recognition · Computer Science 2023-07-26 Lars Nieradzik , Jördis Sieburg-Rockel , Stephanie Helmling , Janis Keuper , Thomas Weibel , Andrea Olbrich , Henrike Stephani

This paper proposes a new method for in vivo and almost real-time identification of biomechanical properties of the human cornea based on non-contact tonometer data. Further goal is to demonstrate the method's functionality based on…

Computational Engineering, Finance, and Science · Computer Science 2021-07-20 Stefan Muench , Mike Roellig , Daniel Balzani

Graph-based machine learning methods are useful tools in the identification and prediction of variation in genetic data. In particular, the comprehension of phenotypic effects at the cellular level is an accelerating research area in…

Quantitative Methods · Quantitative Biology 2024-12-06 Nandini Gadhia , Michalis Smyrnakis , Po-Yu Liu , Damer Blake , Melanie Hay , Anh Nguyen , Dominic Richards , Dong Xia , Ritesh Krishna

We introduce Bayesian Estimation Applied to Multiple Species (BEAMS), an algorithm designed to deal with parameter estimation when using contaminated data. We present the algorithm and demonstrate how it works with the help of a Gaussian…

Instrumentation and Methods for Astrophysics · Physics 2016-12-07 Martin Kunz , Renée Hlozek , Bruce A. Bassett , Mathew Smith , James Newling , Melvin Varughese

Developing rapid methods for pathogen detection and growth monitoring at low cell and analyte concentrations is an important goal, which numerous technologies are working towards solving. Rapid biosensors have already made a dramatic impact…

Peptides are recognized for their varied self-assembly behaviors, forming a wide array of structures and geometries, such as spheres, fibers, and hydrogels, each presenting a unique set of material properties. The functionalities of these…

Biomolecules · Quantitative Biology 2025-05-15 Sarah K. Yorke , Zhenze Yang , Aviad Levin , Alice Ray , Jeremy Owusu Boamah , Tuomas P. J. Knowles , Markus J. Buehler

A hallmark of bacterial populations cultured in vitro is their homogeneity of growth, where the majority of cells display identical growth rate, cell size and content. Recent insights, however, have revealed that even cells growing in…

Quantitative Methods · Quantitative Biology 2022-06-07 Santosh Pandey , Yunsoo Park , Ankita Ankita , Gregory J. Phillips

The microbiome constitutes a complex microbial ecology of interacting components that regulates important pathways in the host. Measurements of microbial abundances are key to learning the intricate network of interactions amongst microbes.…

Methodology · Statistics 2024-06-17 Veronica Vinciotti , Ernst Wit , Francisco Richter

Prompt and accurate detection of system anomalies is essential to ensure the reliability of software systems. Unlike manual efforts that exploit all available run-time information, existing approaches usually leverage only a single type of…

Software Engineering · Computer Science 2023-02-16 Baitong Li , Tianyi Yang , Zhuangbin Chen , Yuxin Su , Yongqiang Yang , Michael R. Lyu

Microbial communities play important roles in the function and maintenance of various biosystems, ranging from human body to the environment. Current methods for analysis of microbial communities are typically based on taxonomic…

Genomics · Quantitative Biology 2015-12-02 Ehsaneddin Asgari , Kiavash Garakani , Mohammad R. K Mofrad

Accurate protein structural ensembles can be determined with metainference, a Bayesian inference method that integrates experimental information with prior knowledge of the system and deals with all sources of uncertainty and errors as well…

Quantitative Methods · Quantitative Biology 2019-01-24 Thomas Löhr , Carlo Camilloni , Massimiliano Bonomi , Michele Vendruscolo

The in vitro clonogenic assay is a technique to study the ability of a cell to form a colony in a culture dish. By optical imaging, dishes with stained colonies can be scanned and assessed digitally. Identification, segmentation and…

Computer Vision and Pattern Recognition · Computer Science 2022-02-15 Delmon Arous , Stefan Schrunner , Ingunn Hanson , Nina F. J. Edin , Eirik Malinen

The evolution of multicellular organisms from monocellular ancestors represents one of the greatest advances of the history of life. The assembly of such multicellular organisms requires signalling and response between cells: over millions…

Cell Behavior · Quantitative Biology 2007-05-23 Graeme J. Ackland , Richard D. L. Hanes , Morrel H. Cohen

The hyperfine transitions of the ground-rotational state of the hydroxyl radical (OH) have emerged as a versatile tracer of the diffuse molecular interstellar medium. We present a novel automated Gaussian decomposition algorithm designed…

Instrumentation and Methods for Astrophysics · Physics 2022-01-05 Anita Petzler , Joanne R Dawson , Mark Wardle

Identifying the counterparts of submillimetre (submm) galaxies (SMGs) in multiwavelength images is a critical step towards building accurate models of the evolution of strongly star-forming galaxies in the early Universe. However, obtaining…

Surface contamination of $^{222}$Rn progeny from the $^{238}$U natural decay chain is one of the most difficult background contributions to measure in rare event searches experiments. In this work we propose AlphaCAMM, a gaseous chamber…

A bipartite graph extensively models relationships between real-world entities of two different types, such as user-product data in e-commerce. Such graph data are inherently becoming more and more streaming, entailing continuous insertions…

Databases · Computer Science 2023-12-07 Serafeim Papadias , Zoi Kaoudi , Varun Pandey , Jorge-Arnulfo Quiane-Ruiz , Volker Markl

Ubiquitous in eukaryotic organisms, the flagellum is a well-studied organelle that is well-known to be responsible for motility in a variety of organisms. Commonly necessitated in their study is the capability to image and subsequently…

Quantitative Methods · Quantitative Biology 2019-03-22 Benjamin J. Walker , Kenta Ishimoto , Richard J. Wheeler

We describe a simple automated method to extract and quantify transient heterogeneous dynamical changes from large datasets generated in single molecule/particle tracking experiments. Based on wavelet transform, the method transforms raw…

Data Analysis, Statistics and Probability · Physics 2013-06-04 Kejia Chen , Bo Wang , Juan Guan , Steve Granick