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Among the best known quantities obtainable from photon correlation measurements are the $g^{(m)}$~correlation functions. Here, we introduce a new procedure to evaluate these correlation functions based on higher-order factorial cumulants…

Mesoscale and Nanoscale Physics · Physics 2022-05-24 Philipp Stegmann , Satyendra Nath Gupta , Gilad Haran , Jianshu Cao

A fluorescence correlation spectroscopy (FCS) system based on two independent measurement volumes is presented. The optical setup and data acquisition hardware are detailed, as well as a complete protocol to control the location, size and…

Optics · Physics 2009-08-26 P. Ferrand , M. Pianta , A. Kress , A. Aillaud , H. Rigneault , D. Marguet

Fluorescence Correlation Spectroscopy (FCS) is a powerful single-molecule technique which allows for measuring motion (diffusion, flow), concentration, and molecular interaction kinetics of fluorescent molecules from picomolar to micromolar…

Fluorescence Correlation Spectroscopy (FCS) is widely used to detect and quantify diffusion processes at the molecular level. The molecules of which diffusion is studied are marked with fluorescent dyes. It is commonly maintained that this…

Biological Physics · Physics 2018-06-12 Mathias Lechelon , Marco Pettini

Cumulant mapping employs a statistical reconstruction of the whole by sampling its parts. The theory developed in this work formalises and extends ad hoc methods of `multi-fold' or `multi-dimensional' covariance mapping. Explicit formulae…

Data Analysis, Statistics and Probability · Physics 2023-11-06 Leszek J. Frasinski

The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…

Quantitative Methods · Quantitative Biology 2024-07-18 Nathan Quiblier , Jan-Michael Rye , Pierre Leclerc , Henri Truong , Abdelkrim Hannou , Laurent Héliot , Hugues Berry

We present a formalism to calculate finite-frequency current correlations in interacting nanoscale conductors. We work within the n-resolved density matrix approach and obtain a multi-time cumulant generating function that provides the…

Mesoscale and Nanoscale Physics · Physics 2011-04-05 C. Emary , D. Marcos , R. Aguado , T. Brandes

We describe a method to probe the spectral fluctuations of a transition over broad ranges of frequencies and timescales with the high spectral resolution of Fourier spectroscopy, and a temporal resolution as high as the excited state…

The currently existing theory of fluorescence correlation spectroscopy(FCS) is based on the linear fluctuation theory originally developed by Einstein, Onsager, Lax, and others as a phenomenological approach to equilibrium fluctuations in…

Biological Physics · Physics 2015-04-01 Mauricio J. Del Razo , Wenxiao Pan , Hong Qian , Guang Lin

Fluorescence Correlation Spectroscopy (FCS) yields measurement parameters (number of molecules, diffusion time) that characterize the concentration and kinetics of fluorescent molecules within a supposedly known observation volume. Absolute…

Biological Physics · Physics 2011-12-23 Charles Edouard Leroux , Irène Wang , Jacques Derouard , Antoine Delon

Shape dependence of higher order correlations introduces complication in direct determination of these quantities. For this reason theoretical and observational progress has been restricted in calculating one point distribution functions…

Astrophysics · Physics 2007-05-23 Dipak Munshi , Adrian L. Melott

The cumulants and factorial moments of photon distribution for squeezed and correlated light are calculated in terms of Chebyshev, Legendre and Laguerre polynomials. The phenomenon of strong oscillations of the ratio of the cumulant to…

High Energy Physics - Theory · Physics 2009-10-28 V. V. Dodonov , I. M. Dremin , V. I. Man'ko , P. G. Polynkin

The Fourier analysis of the final particle distribution followed by cumulant study of the Fourier coefficient event-by-event fluctuation is one of the main approaches for testing the collective evolution in the heavy-ion collision. Using a…

Nuclear Theory · Physics 2021-07-15 Seyed Farid Taghavi

Many cell signaling pathways involve the diffusion of messengers that bind/unbind to intracellular components. Quantifying their net transport rate under different conditions, then requires having separate estimates of their free diffusion…

Subcellular Processes · Quantitative Biology 2017-06-21 Lorena Sigaut , Cecilia Villarruel , María Laura Ponce , Silvina Ponce Dawson

In this paper we discuss the relation of particle number cumulants and correlation functions. It is argued that measuring couplings of the genuine multi-particle correlation functions could provide cleaner information on possible…

Nuclear Theory · Physics 2017-05-17 Adam Bzdak , Volker Koch , Nils Strodthoff

Federated causal discovery aims to uncover the causal relationships between entities while protecting data privacy, which has significant importance and numerous applications in real-world scenarios. Existing federated causal structure…

Machine Learning · Computer Science 2025-07-10 Wei Chen , Wanyang Gu , Linjun Peng , Ruichu Cai , Zhifeng Hao , Kun Zhang

In order to discern aggregation in solutions, we present a quantum mechanical analog of the photon statistics from fluorescent molecules diffusing through a focused beam. A generating functional is developed to fully describe the…

Biological Physics · Physics 2009-11-10 Hai-cang Ren , Noel L. Goddard , Gregoire Altan-Bonnet , Albert Libchaber

The Fluorescence Correlation Spectroscopy (FCS) spectrum G(t) and Raster Image Correlation Spectroscopy (RICS) spectrum R(t) of dilute diffusing particles are determined by the displacement distribution function P(x,t) of the particles and…

Soft Condensed Matter · Physics 2017-06-07 George D. J. Phillies

We propose an alternative formulation of the sensor method presented in [Phys. Rev. Lett 109, 183601 (2012)] for the calculation of frequency-filtered and time-resolved photon correlations. Our approach is based on an algebraic expansion of…

Quantum Physics · Physics 2018-12-26 David I. H. Holdaway , Valentina Notararigo , Alexandra Olaya-Castro

We calculate the second-order correlation function for the atomic fluorescence in the two-photon resonance operation of a driven dissipative Jaynes-Cummings oscillator. We employ a minimal four-level model comprising the driven two-photon…

Quantum Physics · Physics 2022-03-08 Th. K. Mavrogordatos , C. Lledó
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