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Clinical pathways are specialized healthcare plans that model patient treatment procedures. They are developed to provide criteria-based progression and standardize patient treatment, thereby improving care, reducing resource use, and…

Machine Learning · Computer Science 2025-12-04 Francesco Vitale , Nicola Mazzocca

Predicting drug responses using genetic and transcriptomic features is crucial for enhancing personalized medicine. In this study, we implemented an ensemble of machine learning algorithms to analyze the correlation between genetic and…

Genomics · Quantitative Biology 2025-07-04 Johannes Schlüter , Alexander Schönhuth

Vector space methods that measure semantic similarity and relatedness often rely on distributional information such as co--occurrence frequencies or statistical measures of association to weight the importance of particular co--occurrences.…

Computation and Language · Computer Science 2017-05-30 Bridget T. McInnes , Ted Pedersen

Detecting semantic similarities between sentences is still a challenge today due to the ambiguity of natural languages. In this work, we propose a simple approach to identifying semantically similar questions by combining the strengths of…

Computation and Language · Computer Science 2020-06-09 Yoan Dimitrov

Neural Sequence-to-Sequence models have proven to be accurate and robust for many sequence prediction tasks, and have become the standard approach for automatic translation of text. The models work in a five stage blackbox process that…

Computation and Language · Computer Science 2018-10-17 Hendrik Strobelt , Sebastian Gehrmann , Michael Behrisch , Adam Perer , Hanspeter Pfister , Alexander M. Rush

A novel adaptive binary decoding algorithm for LDPC codes is proposed, which reduces the decoding complexity while having a comparable or even better performance than corresponding non-adaptive alternatives. In each iteration the variable…

Information Theory · Computer Science 2009-04-24 Ingmar Land , Gottfried Lechner , Lars K. Rasmussen

Most of existing correlation filter-based tracking approaches only estimate simple axis-aligned bounding boxes, and very few of them is capable of recovering the underlying similarity transformation. To tackle this challenging problem, in…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Yang Li , Jianke Zhu , Steven C. H. Hoi , Wenjie Song , Zhefeng Wang , Hantang Liu

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

The variation in DNA copy number carries information on the modalities of genome evolution and misregulation of DNA replication in cancer cells; its study can be helpful to localize tumor suppressor genes, distinguish different populations…

Methodology · Statistics 2012-03-20 Zhongyang Zhang , Kenneth Lange , Chiara Sabatti

Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…

Today, we are seeing an ever-increasing number of clinical notes that contain clinical results, images, and textual descriptions of patient's health state. All these data can be analyzed and employed to cater novel services that can help…

Computation and Language · Computer Science 2021-06-10 Danilo Dessi , Rim Helaoui , Vivek Kumar , Diego Reforgiato Recupero , Daniele Riboni

A number of statistical models have been successfully developed for the analysis of high-throughput data from a single source, but few methods are available for integrating data from different sources. Here we focus on integrating gene…

A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex…

Other Quantitative Biology · Quantitative Biology 2014-03-12 Jian-Jun Shu , Li Shan Ouw

Duplicated code has a negative impact on the quality of software systems and should be detected at least. In this paper, we discuss an approach that improves source code retrieval using the structural information about the programs. We…

Software Engineering · Computer Science 2013-08-19 Yoshihisa Udagawa

Automatic International Classification of Diseases (ICD) coding aims to assign multiple ICD codes to a medical note with average length of 3,000+ tokens. This task is challenging due to a high-dimensional space of multi-label assignment…

Computation and Language · Computer Science 2022-10-14 Zhichao Yang , Shufan Wang , Bhanu Pratap Singh Rawat , Avijit Mitra , Hong Yu

Tagging news articles or blog posts with relevant tags from a collection of predefined ones is coined as document tagging in this work. Accurate tagging of articles can benefit several downstream applications such as recommendation and…

Computation and Language · Computer Science 2017-07-18 Sheng Chen , Akshay Soni , Aasish Pappu , Yashar Mehdad

Motivated by differential co-expression analysis in genomics, we consider in this paper estimation and testing of high-dimensional differential correlation matrices. An adaptive thresholding procedure is introduced and theoretical…

Methodology · Statistics 2015-10-22 T. Tony Cai , Anru Zhang

We present a novel scalable framework for image change detection (ICD) from an on-board 3D imagery system. We argue that existing ICD systems are constrained by the time required to align a given query image with individual reference image…

Computer Vision and Pattern Recognition · Computer Science 2019-04-09 Kojima Yusuke , Tanaka Kanji , Yang Naiming , Hirota Yuji

With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try…

In cancer biomarker development, a key objective is to evaluate whether a new biomarker, when combined with an established one, improves early cancer detection compared to using the established biomarker alone. Incremental value is often…

Methodology · Statistics 2025-11-21 Indrila Ganguly , Ying Huang