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Among these, D-peptides are resistant to proteolysis, exhibit greater in vivo stability, and are easier to synthesize. Despite advances in deep learning for peptide discovery, the scarcity of natural D-protein data limits the transfer of…

Computational Engineering, Finance, and Science · Computer Science 2026-05-04 Fang Wu , Shuting Jin , Xiangru Tang , Junlin Xu , Mark Gerstein , James Zou

Visual Molecular Dynamics (VMD) is one of the most widely used molecular graphics software in the community of theoretical simulations. So far, however, it still lacks a graphical user interface (GUI) for molecular manipulations when doing…

Biomolecules · Quantitative Biology 2020-07-03 ChenChen Wu , Shengtang Liu , Shitong Zhang , Zaixing Yang

Functional Magnetic Resonance Imaging (fMRI) relies on multi-step data processing pipelines to accurately determine brain activity; among them, the crucial step of spatial smoothing. These pipelines are commonly suboptimal, given the local…

Computer Vision and Pattern Recognition · Computer Science 2017-10-03 Albert Vilamala , Kristoffer Hougaard Madsen , Lars Kai Hansen

Molecular dynamics (MD) simulations are essential for understanding biomolecular systems but remain challenging to automate. Recent advances in large language models (LLM) have demonstrated success in automating complex scientific tasks…

Artificial Intelligence · Computer Science 2025-02-14 Quintina Campbell , Sam Cox , Jorge Medina , Brittany Watterson , Andrew D. White

Signal transduction and cell function are governed by the spatiotemporal organization of membrane-associated molecules. Despite significant advances in visualizing molecular distributions by 3D light microscopy, cell biologists still have…

Quantitative Methods · Quantitative Biology 2023-04-14 Felix Y. Zhou , Andrew Weems , Gabriel M. Gihana , Bingying Chen , Bo-Jui Chang , Meghan Driscoll , Gaudenz Danuser

We introduce a novel motion estimation method, MaskFlow, that is capable of estimating accurate motion fields, even in very challenging cases with small objects, large displacements and drastic appearance changes. In addition to lower-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-22 Aria Ahmadi , David R. Walton , Tim Atherton , Cagatay Dikici

Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…

Signal Processing · Electrical Eng. & Systems 2019-04-05 Emily E Storey , Amr S. Helmy

Raman spectroscopy is a powerful analytical tool with applications ranging from quality control to cutting edge biomedical research. One particular area which has seen tremendous advances in the past decade is the development of powerful…

Signal Processing · Electrical Eng. & Systems 2020-06-19 M. Hamed Mozaffari , Li-Lin Tay

Functional magnetic resonance spectroscopy (fMRS) quantifies metabolic variations upon presentation of a stimulus and can therefore provide complementary information compared to functional magnetic resonance imaging (fMRI). However, to our…

Medical Physics · Physics 2020-01-24 Clémence Ligneul , Francisca F. Fernandes , Noam Shemesh

Nuclear magnetic resonance (NMR) spectroscopy serves as an indispensable tool in chemistry and biology but often suffers from long experimental time. We present a proof-of-concept of application of deep learning and neural network for…

Medical Physics · Physics 2019-05-15 Xiaobo Qu , Yihui Huang , Hengfa Lu , Tianyu Qiu , Di Guo , Tatiana Agback , Vladislav Orekhov , Zhong Chen

Hospitals around the world collect massive amounts of physiological data from their patients every day. Recently, there has been an increase in research interest to subject this data to statistical analysis to gain more insights and provide…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-03-04 Anand Jayarajan , Kimberly Hau , Andrew Goodwin , Gennady Pekhimenko

Accurate measurements of cosmic ray proton flux are essential for studying the modulation processes of cosmic rays during the solar activity cycle. A proton flux measurement method, based on ground-based neutron monitor (NM) data and deep…

Solar and Stellar Astrophysics · Physics 2025-05-28 Pengwei Zhao , Jianqi Yan , Alex P. Leung , Jie Feng

We propose a framework using normalizing-flow based models, SELF-Referencing Embedded Strings, and multi-objective optimization that efficiently generates small molecules. With an initial training set of only 100 small molecules, FastFlows…

Chemical Physics · Physics 2022-02-01 Nathan C. Frey , Vijay Gadepally , Bharath Ramsundar

BlenderProc is a modular procedural pipeline, which helps in generating real looking images for the training of convolutional neural networks. These can be used in a variety of use cases including segmentation, depth, normal and pose…

Computer Vision and Pattern Recognition · Computer Science 2019-11-06 Maximilian Denninger , Martin Sundermeyer , Dominik Winkelbauer , Youssef Zidan , Dmitry Olefir , Mohamad Elbadrawy , Ahsan Lodhi , Harinandan Katam

Mass spectrometry is a powerful and widely used tool for identifying molecular structures due to its sensitivity and ability to profile complex samples. However, translating spectra into full molecular structures is a difficult,…

Machine Learning · Computer Science 2026-03-13 Ghaith Mqawass , Tuan Le , Fabian Theis , Djork-Arné Clevert

Introduction of a dielectric material in an NMR probe head modifies the frequency response of the probe circuit, a phenomenon revealed by the detuning of the probe. For NMR spectroscopy, this detuning is corrected for by tuning and matching…

Zero-shot MRI reconstruction relies on generative priors, but single-modality unconditional priors produce hallucinations under severe ill-posedness. In many clinical workflows, complementary MRI acquisitions (e.g. high-quality structural…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Seunghoi Kim , Chen Jin , Henry F. J. Tregidgo , Matteo Figini , Daniel C. Alexander

Optical flow is an indispensable building block for various important computer vision tasks, including motion estimation, object tracking, and disparity measurement. In this work, we propose TransFlow, a pure transformer architecture for…

Computer Vision and Pattern Recognition · Computer Science 2023-04-25 Yawen Lu , Qifan Wang , Siqi Ma , Tong Geng , Yingjie Victor Chen , Huaijin Chen , Dongfang Liu

Molecular representation learning (MRL) is a key step to build the connection between machine learning and chemical science. In particular, it encodes molecules as numerical vectors preserving the molecular structures and features, on top…

Quantitative Methods · Quantitative Biology 2023-11-30 Zhichun Guo , Kehan Guo , Bozhao Nan , Yijun Tian , Roshni G. Iyer , Yihong Ma , Olaf Wiest , Xiangliang Zhang , Wei Wang , Chuxu Zhang , Nitesh V. Chawla

Background: Software is an important windows to offer a variety of complex instrument control and data processing for nuclear magnetic resonance (NMR) spectrometer. NMR software should allow researchers to flexibly implement various…

Quantitative Methods · Quantitative Biology 2021-03-30 Zao Liu , Kan Song , Zhiwei Chen
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