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Autism spectrum disorder (ASD) is regarded as a brain disease with globally disrupted neuronal networks. Even though fMRI studies have revealed abnormal functional connectivity in ASD, they have not reached a consensus of the disrupted…

Computer Vision and Pattern Recognition · Computer Science 2017-07-26 Hongyoon Choi

Deep learning models based on resting-state functional magnetic resonance imaging (rs-fMRI) have been widely used to diagnose brain diseases, particularly autism spectrum disorder (ASD). Existing studies have leveraged the functional…

Machine Learning · Computer Science 2023-10-06 Wonsik Jung , Eunjin Jeon , Eunsong Kang , Heung-Il Suk

Autism spectrum disorder is one of the leading neurodevelopmental disorders in our world, present in over 1% of the population and rapidly increasing in prevalence, yet the condition lacks a robust, objective, and efficient diagnostic.…

Neurons and Cognition · Quantitative Biology 2024-03-04 Annie Adhikary

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by atypical functional brain connectivity and subtle structural alterations. rs-fMRI has been widely used to identify disruptions in large-scale brain…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Ansar Rahman , Hassan Shojaee-Mend , Sepideh Hatamikia

Mental disorders such as Autism Spectrum Disorders (ASD) are heterogeneous disorders that are notoriously difficult to diagnose, especially in children. The current psychiatric diagnostic process is based purely on the behavioural…

Machine Learning · Computer Science 2019-04-17 Taban Eslami , Vahid Mirjalili , Alvis Fong , Angela Laird , Fahad Saeed

Autism spectrum disorder (ASD) is one of the major developmental disorders affecting children. Recently, it has been hypothesized that ASD is associated with atypical brain connectivities. A substantial body of researches use Pearson's…

Neurons and Cognition · Quantitative Biology 2019-03-06 Biwei Huang , Kun Zhang , Ruben Sanchez-Romero , Joseph Ramsey , Madelyn Glymour , Clark Glymour

We propose a novel optimization framework to predict clinical severity from resting state fMRI (rs-fMRI) data. Our model consists of two coupled terms. The first term decomposes the correlation matrices into a sparse set of representative…

Neurons and Cognition · Quantitative Biology 2024-11-25 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart H. Mostofsky , Archana Venkataraman

The development of noninvasive brain imaging such as resting-state functional magnetic resonance imaging (rs-fMRI) and its combination with AI algorithm provides a promising solution for the early diagnosis of Autism spectrum disorder…

Image and Video Processing · Electrical Eng. & Systems 2022-04-11 Fangyu Zhang , Yanjie Wei , Jin Liu , Yanlin Wang , Wenhui Xi , Yi Pan

Anatomical brain parcellations dominate rs-fMRI-based Autism Spectrum Disorder (ASD) classification, yet their rigid boundaries may fail to capture the idiosyncratic connectivity patterns that characterise ASD. We present a graph-based deep…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Syeda Hareem Madani , Noureen Bibi , Adam Rafiq Jeraj , Sumra Khan , Anas Zafar , Rizwan Qureshi

We propose a matrix factorization technique that decomposes the resting state fMRI (rs-fMRI) correlation matrices for a patient population into a sparse set of representative subnetworks, as modeled by rank one outer products. The…

Signal Processing · Electrical Eng. & Systems 2018-07-26 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

Currently, the diagnosis of Autism Spectrum Disorder (ASD) is dependent upon a subjective, time-consuming evaluation of behavioral tests by an expert clinician. Non-invasive functional MRI (fMRI) characterizes brain connectivity and may be…

Machine Learning · Computer Science 2020-05-26 Cooper J. Mellema , Alex Treacher , Kevin P. Nguyen , Albert Montillo

Autism Spectrum Disorder (ASD) is a multi-factorial neurodevelopmental disorder, whose causes are still poorly understood. Effective therapies to reduce all the heterogeneous symptoms of the disorder do not exists yet, but behavioural…

Neurons and Cognition · Quantitative Biology 2025-06-02 Elisa Ferrari , Alessandra Retico , Alessandro Cellerino , Davide Bacciu

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Finding the biomarkers associated with ASD is extremely helpful to understand the underlying roots of the disorder and can lead to earlier diagnosis and more targeted…

Computer Vision and Pattern Recognition · Computer Science 2018-08-28 Xiaoxiao Li , Nicha C. Dvornek , Juntang Zhuang , Pamela Ventola , James S. Duncan

Early diagnosis and intervention for Autism Spectrum Disorder (ASD) has been shown to significantly improve the quality of life of autistic individuals. However, diagnostics methods for ASD rely on assessments based on clinical presentation…

Image and Video Processing · Electrical Eng. & Systems 2025-03-05 Suryansh Vidya , Kush Gupta , Amir Aly , Andy Wills , Emmanuel Ifeachor , Rohit Shankar

The Alzheimer's Disease Neuroimaging Initiative (ADNI) provides a comprehensive multimodal neuroimaging resource for studying aging and Alzheimer's disease (AD). Since its second wave, ADNI has increasingly collected resting-state…

The human brain is a complex network comprised of functionally and anatomically interconnected brain regions. A growing number of studies have suggested that empirical estimates of brain networks may be useful for discovery of biomarkers of…

Neurons and Cognition · Quantitative Biology 2022-11-15 Andrew Hannum , Mario A. Lopez , Saúl A. Blanco , Richard F. Betzel

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

Machine Learning · Computer Science 2022-06-08 Ahmed El Gazzar , Rajat Mani Thomas , Guido Van Wingen

Increasing the volume of training data can enable the auxiliary diagnostic algorithms for Autism Spectrum Disorder (ASD) to learn more accurate and stable models. However, due to the significant heterogeneity and domain shift in rs-fMRI…

Neurons and Cognition · Quantitative Biology 2025-07-11 Yiqian Luo , Qiurong Chen , Fali Li , Peng Xu , Yangsong Zhang

Autism Spectrum Disorder is a condition characterized by a typical brain development leading to impairments in social skills, communication abilities, repetitive behaviors, and sensory processing. There have been many studies combining…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Junlin Song , Yuzhuo Chen , Yuan Yao , Zetong Chen , Renhao Guo , Lida Yang , Xinyi Sui , Qihang Wang , Xijiao Li , Aihua Cao , Wei Li

We propose a model for diagnosing Autism spectrum disorder (ASD) using multimodal magnetic resonance imaging (MRI) data. Our approach integrates brain connectivity data from diffusion tensor imaging (DTI) and functional MRI (fMRI),…

Neurons and Cognition · Quantitative Biology 2024-10-10 Lu Wei , Yi Huang , Guosheng Yin , Fode Zhang , Manxue Zhang , Bin Liu