Related papers: Toward a systems-level view of mitotic checkpoints
The process controlling the diferentiation of stem, or progenitor, cells into one specific functional direction is called lineage specification. An important characteristic of this process is the multi-lineage priming, which requires the…
The Lieb-Schultz-Mattis theorem and its higher dimensional generalizations by Oshikawa and Hastings require that translationally invariant 2D spin systems with a half-integer spin per unit cell must either have a continuum of low energy…
Rare events such as conformational changes in biomolecules, phase transitions, and chemical reactions are central to the behavior of many physical systems, yet they are extremely difficult to study computationally because unbiased…
Cell migration is crucial to many physiological and pathological processes. During migration, a cell adapts its morphology, including the overall morphology and nucleus morphology, in response to various cues in complex microenvironments,…
One of the main and largely unexplored challenges in evolving the weights of neural networks using genetic algorithms is to find a sensible crossover operation between parent networks. Indeed, naive crossover leads to functionally damaged…
We investigate the dynamics of cancer initiation in a mathematical model with one driver mutation and several passenger mutations. Our analysis is based on a multi type branching process: We model individual cells which can either divide or…
Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interactions evolve in response to changes in the protein's chemical or…
We study a 2D measurement-only random circuit motivated by the Bacon-Shor error correcting code. We find a rich phase diagram as one varies the relative probabilities of measuring nearest neighbor Pauli XX and ZZ check operators. In the…
The ability to detect failures and anomalies are fundamental requirements for building reliable systems for computer vision applications, especially safety-critical applications of semantic segmentation, such as autonomous driving and…
The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth,…
Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking…
Time-reversal symmetric charge and spin transport through a molecule comprising two-orbital channels and connected to two leads is analyzed. It is demonstrated that spin-resolved currents are generated when spin-flip processes are…
The control and active manipulation of spin-orbit coupling (SOC) in photonic systems is fundamental in the development of modern spin optics and topological photonic devices. Here, we demonstrate the control of an artificial…
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs),…
The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell…
In a recent paper [Phys. Rev. E 57, p. 1550 (1998)] we demonstrated that the symmetries of the evolution equation and the target state have a profound effect on the selection of the admissible control parameters. In the present paper we…
Spin splitting underpins a vast range of spin-dependent phenomena. Traditionally, two primary mechanisms generate such splitting: relativistic spin-orbit coupling (SOC) and nonrelativistic magnetic exchange coupling (MEC). Governed by…
Ab initio molecular dynamics including non-adiabatic and spin-orbit couplings on equal footing is used to unravel the deactivation of cytosine after UV light absorption. Intersystem crossing (ISC) is found to compete directly with internal…
Genomic aberrations, such as somatic copy number alterations, are frequently observed in tumor tissue. Recurrent aberrations, occurring in the same region across multiple subjects, are of interest because they may highlight genes associated…
Evolutionary branching points are a paradigmatic feature of adaptive dynamics, because they are potential starting points for adaptive diversification. The antithesis to evolutionary branching points are Continuously stable strategies…