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One essential component in the construction of patent landscapes in biomedical research and development (R&D) is identifying the most seminal patents. Hitherto, the identification of seminal patents required subject matter experts within…
The Precision Medicine Initiative states that treatments for a patient should take into account not only the patient's disease, but his/her specific genetic variation as well. The vast biomedical literature holds the potential for…
The number of biomedical research articles published has doubled in the past 20 years. Search engine based systems naturally center around searching, but researchers may not have a clear goal in mind, or the goal may be expressed in a query…
The field of Artificial Intelligence in healthcare is evolving at an unprecedented pace, driven by rapid advancements in machine learning and the recent breakthroughs in large language models. While these innovations hold immense potential…
Background: Citation analysis has become an important tool for research performance assessment in the medical sciences. However, different areas of medical research may have considerably different citation practices, even within the same…
RPYS is a bibliometric method originally introduced in order to reveal the historical roots of research topics or fields. RPYS does not identify the most highly cited papers of the publication set being studied (as is usually done by…
Citations between scientific papers and related bibliometric indices, such as the $h$-index for authors and the impact factor for journals, are being increasingly used - often in controversial ways - as quantitative tools for research…
Reference Publication Year Spectroscopy (RPYS) and Multi-RPYS provide algorithmic approaches to reconstructing the intellectual histories of scientific fields. With this brief communication, we describe a technical advancement for…
Despite the increasing use of citation-based metrics for research evaluation purposes, we do not know yet which metrics best deliver on their promise to gauge the significance of a scientific paper or a patent. We assess 17 network-based…
The value of research containing novel combinations of molecules can be seen in many innovative and award-winning research programs. Despite calls to use innovative approaches to address common diseases, an increasing majority of research…
"Citation classics" are not only highly cited, but also cited during several decades. We test whether the peaks in the spectrograms generated by Reference Publication Years Spectroscopy (RPYS) indicate such long-term impact by comparing…
Biomedical research encompasses diverse types of activities, from basic science ("bench") to clinical medicine ("bedside") to bench-to-bedside translational research. It, however, remains unclear whether different types of research receive…
With rising life expectancies around the world and an older scientific workforce than ever before, what does aging mean for individual scientists, and what do aging scientists mean for scientific progress as a whole? Here we examine how…
Citation metrics are becoming pervasive in the quantitative evaluation of scholars, journals and institutions. More then ever before, hiring, promotion, and funding decisions rely on a variety of impact metrics that cannot disentangle…
Understanding large molecular networks consisting of entities such as genes, proteins or RNAs that interact in complex ways to drive the cellular machinery has been an active focus of systems biology. Computational approaches have played a…
Bibliometric information retrieval in databases can employ different strategies. Com-monly, queries are performed by searching in title, abstract and/or author keywords (author vocabulary). More advanced queries employ database keywords to…
We introduce the quantitative method named "reference publication year spectroscopy" (RPYS). With this method one can determine the historical roots of research fields and quantify their impact on current research. RPYS is based on the…
Large language models (LLMs) are increasingly transforming biomedical discovery and clinical innovation, yet their impact extends far beyond algorithmic revolution-LLMs are restructuring how scientific collaboration occurs, who…
As the global population continues to age, there is an increasing demand for ways to accurately quantify the biological processes underlying aging. Biological age, unlike chronological age, reflects an individual's physiological state,…
Over the last four decades, the way knowledge is created in academia has transformed dramatically: research teams have grown larger, scholars draw from ever-wider pools of prior work, and the most influential discoveries increasingly emerge…