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We consider the inverse problem of parameter estimation in a diffuse interface model for tumour growth. The model consists of a fourth-order Cahn-Hilliard system and contains three phenomenological parameters: the tumour proliferation rate,…

Numerical Analysis · Mathematics 2019-05-10 Christian Kahle , Kei Fong Lam , Jonas Latz , Elisabeth Ullmann

The purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen-Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models, and prove convergence…

Analysis of PDEs · Mathematics 2022-12-23 Tim Laux , Kerrek Stinson , Clemens Ullrich

The paper deals with a phase field system of Cahn-Hilliard type. For positive viscosity coefficients, the authors prove an existence and uniqueness result and study the long time behavior of the solution by assuming the nonlinearities to be…

Analysis of PDEs · Mathematics 2014-03-24 Pierluigi Colli , Gianni Gilardi , Danielle Hilhorst

In this paper we perform an asymptotic analysis for two different vanishing viscosity coefficients occurring in a phase field system of Cahn-Hilliard type that was recently introduced in order to approximate a tumor growth model. In…

Analysis of PDEs · Mathematics 2015-02-02 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Juergen Sprekels

We use a diffuse interface method for solving Poisson's equation with a Dirichlet condition on an embedded curved interface. The resulting diffuse interface problem is identified as a standard Dirichlet problem on approximating regular…

Numerical Analysis · Mathematics 2015-11-23 Matthias Schlottbom

This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly…

Mathematical Physics · Physics 2017-01-20 Andrea Tosin

We introduce a diffuse interface model describing the evolution of a mixture of two different viscous incompressible fluids of equal density. The main novelty of the present contribution consists in the fact that the effects of temperature…

Analysis of PDEs · Mathematics 2014-01-15 Michela Eleuteri , Elisabetta Rocca , Giulio Schimperna

We construct a diffuse-interface model of two-phase solidification that quantitatively reproduces the classic free boundary problem on solid-liquid interfaces in the thin-interface limit. Convergence tests and comparisons with boundary…

Materials Science · Physics 2009-11-10 R. Folch , M. Plapp

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

Optimization and Control · Mathematics 2021-10-12 Matthias Ebenbeck , Patrik Knopf

This paper is concerned with a phase field system of Cahn-Hilliard type that is related to a tumor growth model and consists of three equations in terms of the variables order parameter, chemical potential and nutrient concentration. This…

Analysis of PDEs · Mathematics 2015-03-04 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

Analysis of PDEs · Mathematics 2022-02-24 Giulio Schimperna

We develop a computational method for simulating the nonlinear dynamics of an elastic tumor-host interface. This work is motivated by the recent linear stability analysis of a two-phase tumor model with an elastic membrane interface in 2D.…

Numerical Analysis · Mathematics 2019-12-12 Min-Jhe Lu , Chun Liu , Shuwang Li

We consider the sharp interface limit of a convective Allen-Cahn equation, which can be part of a Navier-Stokes/Allen-Cahn system, for different scalings of the mobility $m_\varepsilon=m_0\varepsilon^\theta$ as $\varepsilon\to 0$. In the…

Analysis of PDEs · Mathematics 2021-02-22 Helmut Abels

We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…

Analysis of PDEs · Mathematics 2022-10-14 Samiha Belmor

In this paper we consider the flow of two incompressible, viscous and immiscible fluids in a bounded domain, with different densities and viscosities. This model consists of a coupled system of Navier-Stokes and Mullins-Sekerka type parts,…

Analysis of PDEs · Mathematics 2025-05-13 Helmut Abels , Andrea Poiatti

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

Analysis of PDEs · Mathematics 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

Analysis of PDEs · Mathematics 2024-03-12 Jiajun Tong , Yuming Paul Zhang

We investigate the singular limit, as $\ep \to 0$, of the Fisher equation $\partial_t u=\ep \Delta u + \ep ^{-1}u(1-u)$ in the whole space. We consider initial data with compact support plus, possibly, perturbations very small as $\Vert x…

Analysis of PDEs · Mathematics 2009-10-13 Matthieu Alfaro , Arnaud Ducrot

We prove existence of weak solutions for a diffuse interface model for the flow of two viscous incompressible Newtonian fluids in a bounded domain in two and three space dimensions. In contrast to previous works, we study a new model…

Analysis of PDEs · Mathematics 2015-06-03 Helmut Abels , Daniel Depner , Harald Garcke

We consider the interaction between a free flowing fluid and a porous medium flow, where the free flowing fluid is described using the time dependent Stokes equations, and the porous medium flow is described using Darcy's law in the primal…

Numerical Analysis · Mathematics 2022-10-05 Martina Bukač , Boris Muha , Abner J. Salgado
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