Related papers: The Evolving Definition of Sepsis
Detecting and predicting septic shock early is crucial for the best possible outcome for patients. Accurately forecasting the vital signs of patients with sepsis provides valuable insights to clinicians for timely interventions, such as…
Opioid overdose has emerged as a full blown epidemic in the United States. In the last few years, there has been an alarming increase in Opioid related deaths, resulting in the loss of 63,600 lives in 2016 alone. The epidemic which is…
The timeliness of detection of a sepsis event in progress is a crucial factor in the outcome for the patient. Machine learning models built from data in electronic health records can be used as an effective tool for improving this…
Objective: Sepsis is a life-threatening condition. Sequential Organ Failure Assessment (SOFA) score is commonly used to assess organ dysfunction and predict ICU mortality, but it is taken as a static measurement and fails to capture dynamic…
Epilepsy affects more than 50 million people worldwide, making it one of the world's most prevalent neurological diseases. The main symptom of epilepsy is seizures, which occur abruptly and can cause serious injury or death. The ability to…
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis and primarily affects the lungs, as well as other body parts. TB is spread through the air when an infected person coughs, sneezes, or talks.…
Epilepsy is one of the most common neurological diseases globally (around 50 million people worldwide). Fortunately, up to 70% of people with epilepsy could live seizure-free if properly diagnosed and treated, and a reliable technique to…
The COVID-19 pandemic has, worldwide and up to December 2020, caused over 1.7 million deaths, and put the world's most advanced healthcare systems under heavy stress. In many countries, drastic restrictive measures adopted by political…
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept of Misrepair and the concept of accumulation of Misrepairs.…
Leprosy (Hansen's disease) is an infectious, neglected tropical disease caused by the Mycobacterium Leprae (M. Leprae). Each year there are approximately 2,02,189 new cases are detected globally. In the year 2017 more than half million…
Continuous diagnosis and prognosis are essential for intensive care patients. It can provide more opportunities for timely treatment and rational resource allocation, especially for sepsis, a main cause of death in ICU, and COVID-19, a new…
Epilepsy is one of the most common neurological disorders affecting up to 1% of the world's population and approximately 2.5 million people in the United States. Seizures in more than 30% of epilepsy patients are refractory to…
Traditional epidemic models consider that individual processes occur at constant rates. That is, an infected individual has a constant probability per unit time of recovering from infection after contagion. This assumption certainly fails…
Diabetes has affected over 246 million people worldwide with a majority of them being women. According to the WHO report, by 2025 this number is expected to rise to over 380 million. The disease has been named the fifth deadliest disease in…
Stuttering is a complex speech disorder that can be identified by repetitions, prolongations of sounds, syllables or words, and blocks while speaking. Severity assessment is usually done by a speech therapist. While attempts at automated…
Medical investigations focusing on patient survival often generate not only a failure time for each patient but also a sequence of measurements on patient health at annual or semi-annual check-ups while the patient remains alive. Such a…
Understanding the origin of infectious diseases provides scientifically based rationales for implementing public health measures that may help to avoid or mitigate future epidemics. The recent ancestors of a pandemic virus provide…
Atrial Fibrillation (AF) is the most common type of arrhythmia (Greek a-, loss + rhythmos, rhythm = loss of rhythm) leading to hospitalization in the United States. Though sometimes AF is asymptomatic, it increases the risk of stroke and…
Respiratory illnesses are a significant global health burden. Respiratory illnesses, primarily Chronic obstructive pulmonary disease (COPD), is the seventh leading cause of poor health worldwide and the third leading cause of death…
Seizures are common after intracerebral hemorrhage, occurring in 6 to 15% of the patients, mostly in the first 72 hours. Their incidence reaches 30% when subclinical or non-convulsive seizures are diagnosed by continuous…