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HIV is a retrovirus that attacks the human immune system and can lead to death without proper treatment. In collaboration with the WHO and Wits University, we study how to improve the efficiency of HIV testing with the goal of eventual…

Social and Information Networks · Computer Science 2026-01-26 Akseli Kangaslahti , Davin Choo , Lingkai Kong , Milind Tambe , Alastair van Heerden , Cheryl Johnson

Controlling an epidemiological model is often performed using optimal control theory techniques for which the solution depends on the equations of the control system, objective functional and possible state and/or control constraints. In…

Optimization and Control · Mathematics 2021-11-25 Loïc Michel , Cristiana J. Silva , Delfim F. M. Torres

Methods are lacking to handle the problem of survival analysis in the presence of an interval-censored covariate, specifically the case in which the conditional hazard of the primary event of interest depends on the occurrence of a…

Epidemiological models describe the spread of an infectious disease within a population. They capture microscopic details on how the disease is passed on among individuals in various different ways, while making predictions about the state…

Populations and Evolution · Quantitative Biology 2024-02-27 Stefan Hohenegger , Francesco Sannino

With the launch of second line anti-retroviral therapy for HIV infected individuals, there has been an increased expectation on surviving period of people with HIV. We consider previously well-known models in HIV epidemiology where the…

Quantitative Methods · Quantitative Biology 2021-06-15 Arni S. R. Srinivasa Rao

We present a new joint longitudinal and survival model aimed at estimating the association between the risk of an event and the change in and history of a biomarker that is repeatedly measured over time. We use cubic B-splines models for…

Applications · Statistics 2009-10-12 Elizabeth R. Brown

Tuberculosis (TB) and human immunodeficiency virus (HIV) can be considered a deadly human syndemic. In this article, we formulate a model for TB and HIV transmission dynamics. The model considers both TB and acquired immune deficiency…

Dynamical Systems · Mathematics 2014-07-15 Cristiana J. Silva , Delfim F. M. Torres

We introduce a new tuberculosis (TB) mathematical model, with $25$ state-space variables where $15$ are evolution disease states (EDSs), which generalises previous models and takes into account the (seasonal) flux of populations between a…

Populations and Evolution · Quantitative Biology 2018-05-25 Eugenio M. Rocha , Cristiana J. Silva , Delfim F. M. Torres

The spread of COVID-19 makes it essential to investigate its prevalence. In such investigation research, as far as we know, the widely-used sampling methods didn't use the information sufficiently about the numbers of the previously…

Applications · Statistics 2022-01-04 Ze Liu , Siyu Yi , Jianghu , Dong , Min-Qian Liu , Yongdao Zhou

Chikungunya is an emerging threat for health security all over the world which is spreading very fast. Researches for proper forecasting of the incidence rate of chikungunya has been going on in many places in which DARPA has done a very…

Machine Learning · Computer Science 2021-01-12 Sayed Erfan Arefin , Tasnia Ashrafi Heya , Dr Moinul Zaber

For estimating area-specific parameters (quantities) in a finite population, a mixed model prediction approach is attractive. However, this approach strongly depends on the normality assumption of the response values although we often…

Methodology · Statistics 2018-06-12 Shonosuke Sugasawa , Tatsuya Kubokawa

Background: A common modelling approach in public health and epidemiology divides the population under study into compartments containing persons that share the same status. Here we consider a three-state model with the compartments: A, B…

Populations and Evolution · Quantitative Biology 2015-06-19 Ralph Brinks

Compartmental epidemic models with dynamics that evolve over a graph network have gained considerable importance in recent years but analysis of these models is in general difficult due to their complexity. In this paper, we develop two…

Populations and Evolution · Quantitative Biology 2023-05-31 Sei Zhen Khong , Lanlan Su

Existing mortality forecasting methods focus on age-specific mortality rates, which lie in an unconstrained space and overlook the distributional nature of life-table death counts. Few studies have developed and compared forecasting methods…

Methodology · Statistics 2026-04-23 Han Lin Shang , Cristian F. Jiménez-Varón

We estimate patterns of covariation between COVID-19 vaccination rates and a set of widely used indicators of human, social, and economic capital across 146 countries in July 2021 and February 2022. About 70% of the variability in COVID-19…

Physics and Society · Physics 2022-03-02 Cosima Rughinis , Simona-Nicoleta Vulpe , Michael G. Flaherty , Sorina Vasile

When an infectious disease strikes a population, the number of newly reported cases is often the only available information that one can obtain during early stages of the outbreak. An important goal of early outbreak analysis is to obtain a…

Quantitative Methods · Quantitative Biology 2013-05-30 Bahman Davoudi , Babak Pourbohloul , Joel Miller , Rafael Meza , Lauren Ancel Meyers , David J. D. Earn

The probability of the survival of the population of individuals of both sexes of given mature age, procreation rate and structure stability has been searched in the numerical experiment. The populations with long period of reproduction and…

Condensed Matter · Physics 2007-05-23 Kazimierz Pater

Respondent-driven sampling (RDS) is a widely used method for sampling from hard-to-reach human populations, especially groups most at-risk for HIV/AIDS. Data are collected through a peer-referral process in which current sample members…

Methodology · Statistics 2012-09-28 Krista J. Gile , Lisa G. Johnston , Matthew J. Salganik

Understanding how population age structure shapes COVID-19 burden is crucial for pandemic preparedness, yet common summary measures such as median age ignore key distributional features like skewness, bimodality, and the proportional weight…

We study the impact on the epidemiological dynamics of a class of restrictive measures that are aimed at reducing the number of contacts of individuals who have a higher risk of being infected with a transmittable disease. Such measures are…

Populations and Evolution · Quantitative Biology 2021-09-15 Giacomo Cacciapaglia , Stefan Hohenegger , Francesco Sannino
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