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Decompressive craniectomy (DC) is a common surgical procedure consisting of the removal of a portion of the skull that is performed after incidents such as stroke, traumatic brain injury (TBI) or other events that could result in acute…

Image and Video Processing · Electrical Eng. & Systems 2020-07-14 Franco Matzkin , Virginia Newcombe , Susan Stevenson , Aneesh Khetani , Tom Newman , Richard Digby , Andrew Stevens , Ben Glocker , Enzo Ferrante

The internal deformation of the brain is far more complex than the rigid motion of the skull. An ultrasound imaging technique that we have developed has a combination of penetration, frame-rate, and motion detection accuracy required to…

Soft Condensed Matter · Physics 2017-11-08 David Espindola , Stephen Lee , Gianmarco Pinton

Skull-stripping separates the skull region of the head from the soft brain tissues. In many cases of brain image analysis, this is an essential preprocessing step in order to improve the final result. This is true for both registration and…

Computer Vision and Pattern Recognition · Computer Science 2012-04-03 Stefan Bauer , Lutz-P. Nolte , Mauricio Reyes

We consider the mechanisms by which folds, or sulci (troughs) and gyri (crests), develop in the brain. This feature, common to many gyrencephalic species including humans, has attracted recent attention from soft matter physicists. It…

Tissues and Organs · Quantitative Biology 2017-11-27 S. N. Verner , K. Garikipati

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…

Biological Physics · Physics 2013-02-20 Badar Rashid , Michel Destrade , Michael Gilchrist

Whole brain extraction, also known as skull stripping, is a process in neuroimaging in which non-brain tissue such as skull, eyeballs, skin, etc. are removed from neuroimages. Skull striping is a preliminary step in presurgical planning,…

Image and Video Processing · Electrical Eng. & Systems 2020-06-05 Sara Ranjbar , Kyle W. Singleton , Lee Curtin , Cassandra R. Rickertsen , Lisa E. Paulson , Leland S. Hu , J. Ross Mitchell , Kristin R. Swanson

We model the elasticity of the cerebral cortex as a layered material with bending energy along the layers and elastic energy between them in both planar and polar geometries. The cortex is also subjected to axons pulling from the underlying…

Soft Condensed Matter · Physics 2016-02-09 O. V. Manyuhina , David Mayett , J. M. Schwarz

Shear shocks, which exist in a completely different regime from compressional shocks, were recently observed in the brain. These low phase speed ($\approx$ 2 m/s) high Mach number ($\approx$ 1) waves could be the primary mechanism behind…

Medical Physics · Physics 2021-04-27 Bharat B. Tripathi , Sandhya Chandrasekaran , Gianmarco Pinton

During severe impact conditions, brain tissue experiences a rapid and complex deformation, which can be seen as a mixture of compression, tension and shear. Moreover, diffuse axonal injury (DAI) occurs in animals and humans when both the…

Soft Condensed Matter · Physics 2020-09-04 Badar Rashid , Michel Destrade , Michael D. Gilchrist

For long it has been known that specific patterns of folding are necessary for an optimally functioning brain. For instance, lissencephaly and polymicrogyria can lead to severe mental retardation, short life expectancy, epileptic seizures,…

Biological Physics · Physics 2020-04-03 Lucas da Costa Campos , Raphael Hornung , Gerhard Gompper , Jens Elgeti , Svenja Caspers

Buckling instabilities driven by tissue growth underpin key developmental events such as the folding of the brain. Tissue growth is disordered due to cell-to-cell variability, but the effects of this variability on buckling are unknown.…

Soft Condensed Matter · Physics 2025-12-12 Rahul G. Ramachandran , Ricard Alert , Pierre A. Haas

Brain extraction (skull stripping) is a challenging problem in neuroimaging. It is due to the variability in conditions from data acquisition or abnormalities in images, making brain morphology and intensity characteristics changeable and…

Computer Vision and Pattern Recognition · Computer Science 2022-01-31 Duy H. M. Nguyen , Duy M. Nguyen , Mai T. N. Truong , Thu Nguyen , Khanh T. Tran , Nguyen A. Triet , Pham T. Bao , Binh T. Nguyen

Computational biomechanics of the brain for neurosurgery is an emerging area of research recently gaining in importance and practical applications. This review paper presents the contributions of the Intelligent Systems for Medicine…

Computational Engineering, Finance, and Science · Computer Science 2019-04-03 K. Miller , G. R. Joldes , G. Bourantas , S. K. Warfield , D. E. Hyde , R. Kikinis , A. Wittek

In early years of life, the cranium rapidly changes in size and shape to accommodate brain growth, primarily driven by mechanical stress from brain expansion. Developmental disorders such as premature fusion of sutures in craniosynostosis,…

Tissues and Organs · Quantitative Biology 2025-10-30 Mahtab Vafaeefar , Conall Quinn , Ted J. Vaughan

Mild traumatic brain injury (mTBI, also known as concussion) caused by the head impact is a crucial global public health problem, but the physics of mTBI is still unclear. During the impact, the rapid movement of the head injures the brain,…

In comparative and developmental neuroanatomy one encounters questions regarding the deformation of neural tissue under stress. The motivation of this note is an observation (Barbas {\it et al}) that at cortical folds or gyri, the layers of…

Tissues and Organs · Quantitative Biology 2007-05-23 Partha P. Mitra

Brain extraction from images is a common pre-processing step. Many approaches exist, but they are frequently only designed to perform brain extraction from images without strong pathologies. Extracting the brain from images with strong…

Computer Vision and Pattern Recognition · Computer Science 2018-05-10 Xu Han , Roland Kwitt , Stephen Aylward , Spyridon Bakas , Bjoern Menze , Alexander Asturias , Paul Vespa , John Van Horn , Marc Niethammer

Brain extraction is a fundamental step for most brain imaging studies. In this paper, we investigate the problem of skull stripping and propose complementary segmentation networks (CompNets) to accurately extract the brain from T1-weighted…

Computer Vision and Pattern Recognition · Computer Science 2018-10-11 Raunak Dey , Yi Hong

Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Baris Imre , Elina Thibeau-Sutre , Jorieke Reimer , Kuan Kho , Jelmer M. Wolterink

Blood clots, consisting of red blood cells (RBCs) entrapped within a fibrin network, can cause life-threatening conditions such as stroke and heart attack. The recently developed milli-spinner thrombectomy device presents a promising…

Biological Physics · Physics 2025-05-09 Yilong Changa , Guansheng Li , Jay Sim , George Em Karniadakis , Ruike Renee Zhao
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