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Multiple instance learning (MIL) is a promising approach for weakly supervised classification in pathology using whole slide images (WSIs). However, conventional MIL methods such as Attention-Based Deep Multiple Instance Learning (ABMIL)…

Image and Video Processing · Electrical Eng. & Systems 2025-04-28 Hassan Keshvarikhojasteh , Mihail Tifrea , Sibylle Hess , Josien P. W. Pluim , Mitko Veta

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

The presence of missing values often reflects variations in data collection policies, which may shift across time or locations, even when the underlying feature distribution remains stable. Such shifts in the missingness distribution…

Machine Learning · Statistics 2025-08-15 Jihye Lee , Minseo Kang , Dongha Kim

In the last years, the weakly supervised paradigm of multiple instance learning (MIL) has become very popular in many different areas. A paradigmatic example is computational pathology, where the lack of patch-level labels for whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Pablo Morales-Álvarez , Arne Schmidt , José Miguel Hernández-Lobato , Rafael Molina

We consider a weakly supervised learning scenario where the supervision signal is generated by a transition function $\sigma$ of labels associated with multiple input instances. We formulate this problem as \emph{multi-instance Partial…

Machine Learning · Computer Science 2024-07-16 Kaifu Wang , Efthymia Tsamoura , Dan Roth

Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs.…

Applications · Statistics 2014-05-27 Ioannis Papastathopoulos , Jonathan A. Tawn

In classifier (or regression) fusion the aim is to combine the outputs of several algorithms to boost overall performance. Standard supervised fusion algorithms often require accurate and precise training labels. However, accurate labels…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Xiaoxiao Du , Alina Zare

In this paper, we present a new multiple instance learning (MIL) method, called MIS-Boost, which learns discriminative instance prototypes by explicit instance selection in a boosting framework. Unlike previous instance selection based MIL…

Machine Learning · Computer Science 2011-09-13 Emre Akbas , Bernard Ghanem , Narendra Ahuja

This document describes a novel learning algorithm that classifies "bags" of instances rather than individual instances. A bag is labeled positive if it contains at least one positive instance (which may or may not be specifically…

Machine Learning · Computer Science 2014-07-11 Ramasubramanian Sundararajan , Hima Patel , Manisha Srivastava

In computational pathology, cancer grading has been mainly studied as a categorical classification problem, which does not utilize the ordering nature of cancer grades such as the higher the grade is, the worse the cancer is. To incorporate…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Ju Cheon Lee , Keunho Byeon , Boram Song , Kyungeun Kim , Jin Tae Kwak

In learning from aggregate labels, the training data consists of sets or "bags" of feature-vectors (instances) along with an aggregate label for each bag derived from the (usually {0,1}-valued) labels of its instances. In learning from…

Machine Learning · Computer Science 2024-11-12 Yukti Makhija , Rishi Saket

Despite the recent advances in video classification, progress in spatio-temporal action recognition has lagged behind. A major contributing factor has been the prohibitive cost of annotating videos frame-by-frame. In this paper, we present…

Computer Vision and Pattern Recognition · Computer Science 2020-07-22 Anurag Arnab , Chen Sun , Arsha Nagrani , Cordelia Schmid

While much progress has been made in understanding the minimax sample complexity of reinforcement learning (RL) -- the complexity of learning on the "worst-case" instance -- such measures of complexity often do not capture the true…

Machine Learning · Computer Science 2023-07-21 Andrew Wagenmaker , Kevin Jamieson

Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the…

Machine Learning · Computer Science 2023-08-01 Mingcai Chen , Yu Zhao , Zhonghuang Wang , Bing He , Jianhua Yao

Classification and localization are two pillars of visual object detectors. However, in CNN-based detectors, these two modules are usually optimized under a fixed set of candidate (or anchor) bounding boxes. This configuration significantly…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Wei Ke , Tianliang Zhang , Zeyi Huang , Qixiang Ye , Jianzhuang Liu , Dong Huang

In this paper, we introduce directional feedback in the ordinal regression setting, in which the learner receives feedback on whether the predicted label is on the left or the right side of the actual label. This is a weak supervision…

Machine Learning · Computer Science 2025-12-23 Naresh Manwani , M Elamparithy , Tanish Taneja

Learning from noisy ordinal labels is a key challenge in medical imaging. In this work, we ask whether ordinal disease progression labels (better, worse, or stable) can be used to learn a representation allowing to classify disease state.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Gustav Schmidt , Holger Heidrich , Philipp Berens , Sarah Müller

In traditional multiple instance learning (MIL), both positive and negative bags are required to learn a prediction function. However, a high human cost is needed to know the label of each bag---positive or negative. Only positive bags…

Machine Learning · Computer Science 2016-03-17 Zhen Hu , Zhuyin Xue

Weakly Supervised Object Detection (WSOD) enables the training of object detection models using only image-level annotations. State-of-the-art WSOD detectors commonly rely on multi-instance learning (MIL) as the backbone of their detectors…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Zhaofei Wang , Weijia Zhang , Min-Ling Zhang

Standard (network) meta-analysis methods for medical test accuracy evaluation analyse the data separately for each test threshold - wasting data - unless every study reports all thresholds. Previously proposed "multiple threshold" models…

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