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We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn--Hilliard--Darcy system coupled with an elliptic reaction-diffusion equation. The Darcy law gives rise to an elliptic equation for the…

Analysis of PDEs · Mathematics 2018-03-26 Harald Garcke , Kei Fong Lam

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

Analysis of PDEs · Mathematics 2022-06-22 Patrik Knopf , Andrea Signori

In this paper, we study an initial boundary value problem of the Cahn-Hilliard-Darcy system with a non-autonomous mass source term $S$ that models tumor growth. We first prove the existence of global weak solutions as well as the existence…

Analysis of PDEs · Mathematics 2023-07-28 Jie Jiang , Hao Wu , Songmu Zheng

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

Analysis of PDEs · Mathematics 2022-02-24 Giulio Schimperna

We prove existence of weak solutions and weak-strong uniqueness for a mathematical model which couples the evolution of a phase-parameter $\varphi$ satisfying a Cahn-Hilliard type relation with the one of an additional variable $\sigma$…

Analysis of PDEs · Mathematics 2026-04-21 Robert Lasarzik , Elisabetta Rocca , Giulio Schimperna

We analyze a diffuse interface model that describes the dynamics of incompressible two-phase flows influenced by interactions with a soluble chemical substance, encompassing the chemotaxis effect, mass transport, and reactions. In the…

Analysis of PDEs · Mathematics 2026-01-13 Andrea Giorgini , Jingning He , Hao Wu

We consider a diffuse-interface model for two-phase incompressible viscous flows with a soluble surfactant in a bounded porous medium. This hydrodynamic system consists of a Darcy--Forchheimer equation for the seepage velocity…

Analysis of PDEs · Mathematics 2026-03-24 Maurizio Grasselli , Bohan Ouyang , Andrea Poiatti , Hao Wu

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

Analysis of PDEs · Mathematics 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

The global-in-time existence of weak solutions to a degenerate Cahn-Hilliard cross-diffusion system with singular potential in a bounded domain with no-flux boundary conditions is proved. The model consists of two coupled parabolic…

Analysis of PDEs · Mathematics 2024-01-11 Ansgar Jüngel , Yue Li

We study the well-posedness of a coupled Cahn-Hilliard-Stokes-Darcy system which is a diffuse-interface model for essentially immiscible two phase incompressible flows with matched density in a karstic geometry. Existence of finite energy…

Analysis of PDEs · Mathematics 2014-05-22 Daozhi Han , Xiaoming Wang , Hao WU

The aim of this article is to study a Cahn-Hilliard model for a multicomponent mixture with cross-diffusion effects, degenerate mobility and where only one of the species does separate from the others. We define a notion of weak solution…

Analysis of PDEs · Mathematics 2020-07-03 Virginie Ehrlacher , Greta Marino , Jan-Frederik Pietschmann

The global existence of bounded weak solutions to a diffusion system modeling biofilm growth is proven. The equations consist of a reaction-diffusion equation for the substrate concentration and a fourth-order Cahn-Hilliard-type equation…

Analysis of PDEs · Mathematics 2023-07-20 Christoph Helmer , Ansgar Jüngel

We study a nonlinear system coupling the Darcy-Forchheimer-Brinkman equations with a convection-diffusion-reaction equation, arising in reactive transport through porous media. The model features a nonlinear viscosity coupling, Forchheimer…

Analysis of PDEs · Mathematics 2026-01-27 Sahil Kundu , Manmohan Vashisth , Manoranjan Mishra

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We prove existence of weak solutions to a diffuse interface model describing the flow of a fluid through a deformable porous medium consisting of two phases. The system non-linearly couples Biot's equations for poroelasticity, including…

Analysis of PDEs · Mathematics 2024-08-27 Helmut Abels , Harald Garcke , Jonas Haselböck

We analyze a diffuse interface model that describes the dynamics of incompressible two-phase flows with chemotaxis effect. The PDE system couples a Navier-Stokes equation for the fluid velocity, a convective Cahn-Hilliard equation for the…

Analysis of PDEs · Mathematics 2020-02-04 Jingning He

We study a diffuse interface model describing the evolution of the flow of a binary fluid in a Hele-Shaw cell. The model consists of a Cahn-Hilliard-Darcy (CHD) type system with transport and mass source. A relevant physical application is…

Analysis of PDEs · Mathematics 2020-09-29 Andrea Giorgini , Kei Fong Lam , Elisabetta Rocca , Giulio Schimperna

Using basic thermodynamic principles we derive a Cahn--Hilliard--Darcy model for tumour growth including nutrient diffusion, chemotaxis, active transport, adhesion, apoptosis and proliferation. The model generalises earlier models and in…

Analysis of PDEs · Mathematics 2016-06-06 Harald Garcke , Kei Fong Lam , Emanuel Sitka , Vanessa Styles

A well-known diffuse interface model consists of the Navier-Stokes equations nonlinearly coupled with a convective Cahn-Hilliard type equation. This system describes the evolution of an incompressible isothermal mixture of binary-fluids and…

Analysis of PDEs · Mathematics 2011-02-22 Pierluigi Colli , Sergio Frigeri , Maurizio Grasselli

We introduce a new phase field model for tumour growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn--Hilliard equation with source terms for…

Numerical Analysis · Mathematics 2024-06-21 Harald Garcke , Balázs Kovács , Dennis Trautwein
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