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Developers of Molecular Dynamics (MD) codes face significant challenges when adapting existing simulation packages to new hardware. In a continuously diversifying hardware landscape it becomes increasingly difficult for scientists to be…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-03-14 William R. Saunders , James Grant , Eike H. Müller

We report new statistical time-series analysis tools providing significant improvements in the rapid, precision extraction of discrete state dynamics from large databases of experimental observations of molecular machines. By building…

Quantitative Methods · Quantitative Biology 2019-10-23 Max A. Little , Bradley C. Steel , Fan Bai , Yoshiyuki Sowa , Thomas Bilyard , David M. Mueller , Richard M. Berry , Nick S. Jones

In parametric design, the geometric model is edited by changing relevant parameters in the parametric model, which is commonly done sequentially on multiple parameters. Without guidance on allowable parameter ranges that can guarantee the…

Graphics · Computer Science 2022-06-20 Zhihong Tang , Qiang Zou , Shuming Gao

The paper investigates the techniques of quantum computation in metrological predictions, with a particular emphasis on enhancing prediction potential through variational parameter estimation. The applicability of quantum simulations and…

Quantum Physics · Physics 2025-01-31 Vaidik A Sharma , N. Madurai Meenachi , B. Venkatraman

In this study we address existing deficiencies in the literature on applications of Particle Swarm Optimization to generate optimal designs. We present the results of a large computer study in which we bench-mark both efficiency and…

Neural and Evolutionary Computing · Computer Science 2022-06-15 Stephen J. Walsh , John J. Borkowski

Data movement between memory and processors is a major bottleneck in modern computing systems. The processing-in-memory (PIM) paradigm aims to alleviate this bottleneck by performing computation inside memory chips. Real PIM hardware (e.g.,…

Hardware Architecture · Computer Science 2023-10-04 Jinfan Chen , Juan Gómez-Luna , Izzat El Hajj , Yuxin Guo , Onur Mutlu

We examine the issue of assessing the efficiency of components of a parallel program at the example of the MD package LAMMPS. In particular, we look at how LAMMPS deals with the issue and explain why the approach adopted might lead to…

Materials Science · Physics 2016-02-18 Daniel Tameling , Paolo Bientinesi , Ahmed E. Ismail

Large scale atomistic simulations with suitable interatomic potentials are widely employed by scientists or engineers of different areas. Quick generation of high-quality interatomic potentials is of urgent need under present circumstances,…

Materials Science · Physics 2016-11-23 Kun Wang , Wenjun Zhu , Shifang Xiao , Jun Chen , Wangyu Hu

In a software product line (SPL), a collection of software products is defined by their commonalities in terms of features rather than explicitly specifying all products one-by-one. Several verification techniques were adapted to establish…

Software Engineering · Computer Science 2013-12-31 Clemens Dubslaff , Sascha Klüppelholz , Christel Baier

Meshfree simulation methods are emerging as compelling alternatives to conventional mesh-based approaches, particularly in the fields of Computational Fluid Dynamics (CFD) and continuum mechanics. In this publication, we provide a…

Machine Learning · Computer Science 2024-03-21 Paulami Banerjee , Mohan Padmanabha , Chaitanya Sanghavi , Isabel Michel , Simone Gramsch

Based on the particle-in-cell (PIC) plasma simulation method, the speed-limited PIC (SLPIC) method delivers faster kinetic plasma simulation in cases where the particle distributions evolve slowly compared with the maximum stable PIC…

Computational Physics · Physics 2019-01-09 Gregory R. Werner , Thomas G. Jenkins , Andrew M. Chap , John R. Cary

Computational models of human language often involve combinatorial problems. For instance, a probabilistic parser may marginalize over exponentially many trees to make predictions. Algorithms for such problems often employ dynamic…

Computation and Language · Computer Science 2021-09-16 Tim Vieira , Ryan Cotterell , Jason Eisner

The identification of performance-optimizing parameter settings is an important part of the development and application of algorithms. We describe an automatic framework for this algorithm configuration problem. More formally, we provide…

Artificial Intelligence · Computer Science 2014-01-16 Frank Hutter , Thomas Stuetzle , Kevin Leyton-Brown , Holger H. Hoos

Simulating physical systems is a core component of scientific computing, encompassing a wide range of physical domains and applications. Recently, there has been a surge in data-driven methods to complement traditional numerical simulations…

Machine Learning · Computer Science 2021-08-19 Karl Otness , Arvi Gjoka , Joan Bruna , Daniele Panozzo , Benjamin Peherstorfer , Teseo Schneider , Denis Zorin

A promising research direction in enabling LLMs to generate consistently correct code involves addressing their inability to properly estimate program execution, particularly for code they generate. In this work, we demonstrate that Code…

Computation and Language · Computer Science 2026-04-07 Gallil Maimon , Ori Yoran , Felix Kreuk , Michael Hassid , Gal Cohen , Pierre Chambon , Yossi Adi

Despite the numerous uses of semidefinite programming (SDP) and its universal solvability via interior point methods (IPMs), it is rarely applied to practical large-scale problems. This mainly owes to the computational cost of IPMs that…

Optimization and Control · Mathematics 2024-03-19 Yifan Ran , Stefan Vlaski , Wei Dai

Particle swarm optimisation is a metaheuristic algorithm which finds reasonable solutions in a wide range of applied problems if suitable parameters are used. We study the properties of the algorithm in the framework of random dynamical…

Neural and Evolutionary Computing · Computer Science 2015-11-20 J. Michael Herrmann , Adam Erskine , Thomas Joyce

We present a Quality by Design (QbD) styled approach for optimizing lipid nanoparticle (LNP) formulations, aiming to offer scientists an accessible workflow. The inherent restriction in these studies, where the molar ratios of ionizable,…

Applications · Statistics 2023-11-14 Andrew T. Karl , Sean Essex , James Wisnowski , Heath Rushing

Scientific applications are often irregular and characterized by large computationally-intensive parallel loops. Dynamic loop scheduling (DLS) techniques improve the performance of computationally-intensive scientific applications via load…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-08 Ali Mohammed , Ahmed Eleliemy , Florina M. Ciorba , Franziska Kasielke , Ioana Banicescu

Parameter identification for electrochemical battery models has always been challenging due to the multitude of parameters involved, most of which cannot be directly measured. This paper evaluates the efficiency and optimality of three…

Systems and Control · Electrical Eng. & Systems 2025-11-04 Feng Guo , Luis D. Couto , Guillaume Thenaisie