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The identification of meaningful reaction coordinates plays a key role in the study of complex molecular systems whose essential dynamics is characterized by rare or slow transition events. In a recent publication, precise defining…

Computational Physics · Physics 2018-11-14 Andreas Bittracher , Ralf Banisch , Christof Schütte

Solutions of interacting linear polymers are mapped onto a system of ``soft'' spherical particles interacting via an effective pair potential. This coarse-graining reduces the individual monomer-level description to a problem involving only…

Soft Condensed Matter · Physics 2007-05-23 V. Krakoviack , J. P. Hansen , A. A. Louis

We use inverse methods of statistical mechanics to explore trade-offs associated with designing interactions to stabilize self-assembled structures against changes in density or temperature. Specifically, we find isotropic,convex-repulsive…

Soft Condensed Matter · Physics 2018-01-10 William D. Piñeros , Michael Baldea , Thomas M. Truskett

We present a promising coarse-graining strategy for linking micro- and mesoscales of soft matter systems. The approach is based on effective pairwise interaction potentials obtained from detailed atomistic molecular dynamics (MD)…

Soft Condensed Matter · Physics 2007-05-23 A. P. Lyubartsev , M. Karttunen , I. Vattulainen , A. Laaksonen

Particle interactions are key elements of many dynamical systems. In the context of systems described by a Boltzmann equation, such interactions may be described by a collision integral, a multidimensional integral over the momentum-phase…

High Energy Astrophysical Phenomena · Physics 2024-09-27 Christopher N. Everett , Garret Cotter

We consider the effect of non-reciprocity in a binary mixture of self-propelled particles with anti-aligning interactions, where a particle of type A reacts differently to a particle of type B than vice versa. Starting from a well-known…

Statistical Mechanics · Physics 2025-10-03 Jakob Mihatsch , Thomas Ihle

Coarse-grained models are a core computational tool in theoretical chemistry and biophysics. A judicious choice of a coarse-grained model can yield physical insight by isolating the essential degrees of freedom that dictate the…

Statistical Mechanics · Physics 2023-04-12 Shriram Chennakesavalu , David J. Toomer , Grant M. Rotskoff

Understanding mechanisms of rare but important events in complex molecular systems, such as protein folding or ligand (un)binding, requires accurately mapping transition paths from an initial to a final state. The committor is the ideal…

Chemical Physics · Physics 2026-04-28 Rik S. Breebaart , Gianmarco Lazzeri , Roberto Covino , Peter G. Bolhuis

We introduce a direct Boltzmann inversion method to infer the interaction potential in particle systems using as input particle configurations generated at an arbitrary state point of the system. Unlike iterative Boltzmann inversion, the…

Statistical Mechanics · Physics 2026-05-25 Olivier Coquand , Davide Paolino , Ludovic Berthier

With the recent production of polar molecules in the quantum regime, long-range dipolar interactions are expected to facilitate the understanding of strongly interacting many-body quantum systems and to realize lattice spin models for…

We formulate statistical-mechanical inverse methods in order to determine optimized interparticle interactions that spontaneously produce target many-particle configurations. Motivated by advances that give experimentalists greater and…

Soft Condensed Matter · Physics 2007-05-23 Mikael C. Rechtsman , Salvatore Torquato , Frank H. Stillinger

Obtaining a rigorous and reliable method for linking computer simulations of polymer blends and composites at different length scales of interest is a highly desirable goal in soft matter physics. In this paper a multiscale modeling…

Soft Condensed Matter · Physics 2015-05-19 J. McCarty , M. G. Guenza

Coarse-grained (CG) models are often parametrized to reproduce one-dimensional structural correlation functions of an atomically-detailed model along the degrees of freedom governing each interaction potential. While cross correlations…

Soft Condensed Matter · Physics 2019-12-02 Svenja J. Woerner , Tristan Bereau , Kurt Kremer , Joseph F. Rudzinski

Determining the Fourier representation of various molecular interactions is important for constructing density-based field theories from a microscopic point of view, enabling a multiscale bridge between microscopic and mesoscopic…

Chemical Physics · Physics 2024-04-10 Jaehyeok Jin , David R. Reichman

We present a simple model which allows to investigate equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of…

Biological Physics · Physics 2009-11-13 Hans Behringer , Andreas Degenhard , Friederike Schmid

A binary mixture of oppositely charged components confined to a plane such as cationic and anionic lipid bilayers may exhibit local segregation. The relative strength of the net short range interactions, which favors macroscopic…

Soft Condensed Matter · Physics 2009-11-11 Sharon M. Loverde , Yury S. Velichko , Monica Olvera de la Cruz

Mesoscopic molecular dynamics simulations are used to determine the large scale structure of several binary polymer mixtures of various chemical architecture, concentration, and thermodynamic conditions. By implementing an analytical…

Soft Condensed Matter · Physics 2010-04-05 J. McCarty , I. Y. Lyubimov , M. G. Guenza

Polarizable particle systems, including charged colloids, polarizable ions, biomolecular assemblies, and soft nanomaterials, can exhibit contact electrostatic interactions that depart strongly from Coulomb behavior when dielectric mismatch…

Soft Condensed Matter · Physics 2026-05-13 Yanyu Duan , Zecheng Gan

Inverse methods of statistical mechanics are becoming productive tools in the design of materials with specific microstructures or properties. While initial studies have focused on solid-state design targets (e.g, assembly of colloidal…

Soft Condensed Matter · Physics 2015-12-31 Ryan B. Jadrich , Jonathan A. Bollinger , Beth A. Lindquist , Thomas M. Truskett

The spatial suppression of order parameter fluctuations in a critical media produces Critical Casimir forces acting on confining surfaces. This scenario is realized in a critical binary mixture near the demixing transition point that…

Statistical Mechanics · Physics 2014-10-03 Oleg A. Vasilyev