A Coarse-Grained Lattice Model for Molecular Recognition
Biological Physics
2009-11-13 v1
Abstract
We present a simple model which allows to investigate equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility a small number of strong bonds seems to be favored compared to a situation with many but weak bonds.
Cite
@article{arxiv.physics/0608234,
title = {A Coarse-Grained Lattice Model for Molecular Recognition},
author = {Hans Behringer and Andreas Degenhard and Friederike Schmid},
journal= {arXiv preprint arXiv:physics/0608234},
year = {2009}
}
Comments
4 pages, 3 figures, to appear in Phys. Rev. Lett