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Adaptation in the retina is thought to optimize the encoding of natural light signals into sequences of spikes sent to the brain. However, adaptation also entails computational costs: adaptive code is intrinsically ambiguous, because output…

Neurons and Cognition · Quantitative Biology 2014-01-28 Gašper Tkačik , Anandamohan Ghosh , Elad Schneidman , Ronen Segev

To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision…

Neurons and Cognition · Quantitative Biology 2018-10-05 Audrey J. Sederberg , Jason N. MacLean , Stephanie E. Palmer

Neural circuits are able to perform computations under very diverse conditions and requirements. The required computations impose clear constraints on their fine-tuning: a rapid and maximally informative response to stimuli in general…

Neurons and Cognition · Quantitative Biology 2019-10-22 Jens Wilting , Jonas Dehning , Joao Pinheiro Neto , Lucas Rudelt , Michael Wibral , Johannes Zierenberg , Viola Priesemann

Studies of human decision-making demonstrate that environmental regularities, such as natural image statistics or intentionally nonuniform stimulus probabilities, can be exploited to improve efficiency (termed `efficient-coding').…

Neurons and Cognition · Quantitative Biology 2025-09-30 Holly Kular , Robert Kim , John Serences , Nuttida Rungratsameetaweemana

Transport of neural signals in the brain is challenging, owing to neural interference and neural noise. There is experimental evidence of multiplexing of sensory information across population of neurons, particularly in the vertebrate…

Information Theory · Computer Science 2016-12-22 Nithin Nagaraj , K. R. Sahasranand

Respiration is an essential involuntary function necessary for survival. This poses a challenge for the control of breathing. The preB\"otzinger complex (preB\"otC) is a heterogeneous neuronal network responsible for driving the inspiratory…

Neurons and Cognition · Quantitative Biology 2026-04-09 Sreshta Venkatakrishnan , Andrew K. Tryba , Alfredo J. Garcia , Yangyang Wang

Calmodulin, the ubiquitous calcium-activated second messenger in eukaryotes, is an extremely versatile molecule involved in many biological processes: muscular contraction, synaptic plasticity, circadian rhythm, and cell cycle, among…

Molecular Networks · Quantitative Biology 2015-06-19 Massimo Lai , Denis Brun , Stuart J Edelstein , Nicolas Le Novère

We demonstrate that two key theoretical objects used widely in Computational Neuroscience, the phase-resetting curve (PRC) from dynamics and the spike triggered average (STA) from statistical analysis, are closely related under a wide range…

Neurons and Cognition · Quantitative Biology 2007-09-26 G. Bard Ermentrout , Roberto F. Galán Nathaniel N. Urban

We introduce SIM-CE, an advanced, user-friendly modeling and simulation environment in Simulink for performing multi-scale behavioral analysis of the nervous system of Caenorhabditis elegans (C. elegans). SIM-CE contains an implementation…

Neurons and Cognition · Quantitative Biology 2017-03-28 Ramin M. Hasani , Victoria Beneder , Magdalena Fuchs , David Lung , Radu Grosu

Gas concentration detection is important for applications such as gas leakage monitoring. Metal Oxide (MOx) sensors show high sensitivities for specific gases, which makes them particularly useful for such monitoring applications. However,…

Neural and Evolutionary Computing · Computer Science 2024-10-23 Shavika Rastogi , Nik Dennler , Michael Schmuker , André van Schaik

Neuromorphic computing using spike-based learning has broad prospects in reducing computing power. Memristive neurons composed with two locally active memristors have been used to mimic the dynamical behaviors of biological neurons. In this…

Emerging Technologies · Computer Science 2020-04-14 Yeheng Bo , Peng Zhang , Ziqing Luo , Shuai Li , Juan Song , Xinjun Liu

In traditional research approaches, sensory perception and emotion classification have traditionally been considered separate domains. Yet, the significant influence of sensory experiences on emotional responses is undeniable. The natural…

Artificial Intelligence · Computer Science 2024-03-26 Yuhan Xia , Qingqing Zhao , Yunfei Long , Ge Xu , Jia Wang

Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant…

Neurons and Cognition · Quantitative Biology 2007-05-23 Ilya Nemenman , Geoffrey D. Lewen , William Bialek , Rob R. de Ruyter van Steveninck

Biological and living systems process information across spatiotemporal scales, exhibiting the hallmark ability to constantly modulate their behavior to ever-changing and complex environments. In the presence of repeated stimuli, a…

Statistical Mechanics · Physics 2025-02-04 Giorgio Nicoletti , Matteo Bruzzone , Samir Suweis , Marco Dal Maschio , Daniel Maria Busiello

Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and…

Cell polarization is a critical process that separates molecular species into two distinct regions in prokaryotic and eukaryotic cells, guiding biological processes such as cell division and cell differentiation. Although several underlying…

Molecular Networks · Quantitative Biology 2025-01-28 Yixuan Chen , Guoye Guan , Lei-Han Tang , Chao Tang

Fungi cells are capable of sensing extracellular cues through reception, transduction and response systems which allow them to communicate with their host and adapt to their environment. They display effective regulatory protein expressions…

How natural communication sounds are spatially represented across the inferior colliculus, the main center of convergence for auditory information in the midbrain, is not known. The neural representation of the acoustic stimuli results from…

Neurons and Cognition · Quantitative Biology 2016-07-01 Dominika Lyzwa , Florentin Wörgötter

To thrive in dynamic environments, animals must be capable of rapidly and flexibly adapting behavioral responses to a changing context and internal state. Examples of behavioral flexibility include faster stimulus responses when attentive…

Neurons and Cognition · Quantitative Biology 2021-01-27 David Wyrick , Luca Mazzucato

Neurons rely on two interdependent mechanisms, homeostasis and neuromodulation, to maintain robust and adaptable functionality. Calcium homeostasis stabilizes neuronal activity by adjusting ionic conductances, whereas neuromodulation…

Neurons and Cognition · Quantitative Biology 2026-05-13 Arthur Fyon , Guillaume Drion