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Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing and representing patient data prevent widespread practice of scalable EHR-based…

Although increasingly used as a data resource for assembling cohorts, electronic health records (EHRs) pose many analytic challenges. In particular, a patient's health status influences when and what data are recorded, generating sampling…

Methodology · Statistics 2020-04-28 Yifei Sun , Charles E. McCulloch , Kieren A. Marr , Chiung-Yu Huang

Objective: Temporal electronic health records (EHRs) can be a wealth of information for secondary uses, such as clinical events prediction or chronic disease management. However, challenges exist for temporal data representation. We…

Machine Learning · Computer Science 2024-06-11 Feng Xie , Han Yuan , Yilin Ning , Marcus Eng Hock Ong , Mengling Feng , Wynne Hsu , Bibhas Chakraborty , Nan Liu

Survival analysis plays a crucial role in many healthcare decisions, where the risk prediction for the events of interest can support an informative outlook for a patient's medical journey. Given the existence of data censoring, an…

Machine Learning · Computer Science 2023-09-29 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Bin Liu , Mei Liu , Zijun Yao

Electronic Health Records (EHRs) provide vital contextual information to radiologists and other physicians when making a diagnosis. Unfortunately, because a given patient's record may contain hundreds of notes and reports, identifying…

The development of electronic health records (EHR) systems has enabled the collection of a vast amount of digitized patient data. However, utilizing EHR data for predictive modeling presents several challenges due to its unique…

Machine Learning · Computer Science 2024-08-14 Jiaqi Wang , Junyu Luo , Muchao Ye , Xiaochen Wang , Yuan Zhong , Aofei Chang , Guanjie Huang , Ziyi Yin , Cao Xiao , Jimeng Sun , Fenglong Ma

Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data…

Artificial Intelligence · Computer Science 2012-08-20 Casey Bennett , Tom Doub , Rebecca Selove

Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and…

Machine Learning · Computer Science 2026-03-13 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Muddassar Farooq

Large scale electronic health records (EHRs) present an opportunity to quickly identify suitable individuals in order to directly invite them to participate in an observational study. EHRs can contain data from millions of individuals,…

Applications · Statistics 2019-03-18 James E. Barrett , Aylin Cakiroglu , Catey Bunce , Anoop Shah , Spiros Denaxas

Electronic Health Records (EHRs) contain a large volume of heterogeneous patient data, which are useful at the point of care and for retrospective research. These data are typically stored in relational databases. Gaining an integrated view…

Computers and Society · Computer Science 2018-06-04 Dina Levy-Lambert , Jen J. Gong , Tristan Naumann , Tom J. Pollard , John V. Guttag

Hypertrophic cardiomyopathy (HCM) requires accurate risk stratification to inform decisions regarding ICD therapy and follow-up management. Current established models, such as the European Society of Cardiology (ESC) score, exhibit moderate…

Electronic health records (EHR) are increasingly being used for constructing disease risk prediction models. Feature engineering in EHR data however is challenging due to their highly dimensional and heterogeneous nature. Low-dimensional…

Computation and Language · Computer Science 2018-11-29 Spiros Denaxas , Pontus Stenetorp , Sebastian Riedel , Maria Pikoula , Richard Dobson , Harry Hemingway

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

To overcome the limitations of manual administrative coding in geriatric Cardiovascular Risk Management, this study introduces an automated classification framework leveraging unstructured Electronic Health Records (EHRs). Using a dataset…

Computation and Language · Computer Science 2026-03-11 Jacopo Vitale , David Della Morte , Luca Bacco , Mario Merone , Mark de Groot , Saskia Haitjema , Leandro Pecchia , Bram van Es

Predicting future clinical events helps physicians guide appropriate intervention. Machine learning has tremendous promise to assist physicians with predictions based on the discovery of complex patterns from historical data, such as large,…

Predicting the risk of in-hospital mortality from electronic health records (EHRs) has received considerable attention. Such predictions will provide early warning of a patient's health condition to healthcare professionals so that timely…

Machine Learning · Computer Science 2023-08-22 Yuxi Liu , Zhenhao Zhang , Shaowen Qin , Flora D. Salim , Antonio Jimeno Yepes

Background Predicting mortality and resource utilization from electronic health records (EHRs) is challenging yet crucial for optimizing patient outcomes and managing costs in intensive care unit (ICU). Existing approaches predominantly…

Computation and Language · Computer Science 2025-08-29 Yucheng Ruan , Xiang Lan , Daniel J. Tan , Hairil Rizal Abdullah , Mengling Feng

While the volume of electronic health records (EHR) data continues to grow, it remains rare for hospital systems to capture dense physiological data streams, even in the data-rich intensive care unit setting. Instead, typical EHR records…

Machine Learning · Computer Science 2018-12-04 Satya Narayan Shukla , Benjamin M. Marlin

Despite of the pain and limited accuracy of blood tests for early recognition of cardiovascular disease, they dominate risk screening and triage. On the other hand, heart rate variability is non-invasive and cheap, but not considered…

Neural and Evolutionary Computing · Computer Science 2016-12-30 Tamas Madl