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We consider the problem of estimating the effects of a binary treatment on a continuous outcome of interest from observational data in the absence of confounding by unmeasured factors. We provide a new estimator of the population average…

Methodology · Statistics 2020-08-04 James Robins , Mariela Sued , Quanhong Lei-Gomez , Andrea Rotnitzky

Selecting input variables or design points for statistical models has been of great interest in adaptive design and active learning. Motivated by two scientific examples, this paper presents a strategy of selecting the design points for a…

Machine Learning · Statistics 2021-02-12 Chiwoo Park , Peihua Qiu , Jennifer Carpena-Núñez , Rahul Rao , Michael Susner , Benji Maruyama

One of the most popular methodologies for estimating the average treatment effect at the threshold in a regression discontinuity design is local linear regression (LLR), which places larger weight on units closer to the threshold. We…

Methodology · Statistics 2019-02-01 Zach Branson , Maxime Rischard , Luke Bornn , Luke Miratrix

Consider estimating the G-formula for the counterfactual mean outcome under a given treatment regime in a longitudinal study. Bang and Robins provided an estimator for this quantity that relies on a sequential regression formulation of this…

Methodology · Statistics 2018-05-18 Alexander R. Luedtke , Oleg Sofrygin , Mark J. van der Laan , Marco Carone

High-dimensional data can be useful for causal inference by providing many confounders that may bolster the plausibility of the ignorability assumption. Propensity score methods are powerful tools for causal inference, are popular in health…

Methodology · Statistics 2017-10-10 Jacob Spertus , Sharon-Lise Normand

This paper studies regression discontinuity designs (RDD) when linear-in-means spillovers occur between units that are close in their running variable. We show that the RDD estimand depends on the ratio of two terms: (1) the radius over…

Econometrics · Economics 2025-09-16 Eric Auerbach , Yong Cai , Ahnaf Rafi

Regression discontinuity (RD) designs with multiple running variables arise in a growing number of empirical applications, including geographic boundaries and multi-score assignment rules. Although recent methodological work has extended…

Econometrics · Economics 2026-02-04 Artem Samiahulin

Tie-breaker experimental designs are hybrids of Randomized Controlled Trials (RCTs) and Regression Discontinuity Designs (RDDs) in which subjects with moderate scores are placed in an RCT while subjects with extreme scores are…

Methodology · Statistics 2023-01-24 Dan M. Kluger , Art B. Owen

Understanding causal heterogeneous treatment effects based on pretreatment covariates is a crucial aspect of empirical work. Building on Calonico, Cattaneo, Farrell, Palomba, and Titiunik (2025), this article discusses the software package…

There is a dearth of robust methods to estimate the causal effects of multiple treatments when the outcome is binary. This paper uses two unique sets of simulations to propose and evaluate the use of Bayesian Additive Regression Trees…

Methodology · Statistics 2020-01-22 Liangyuan Hu , Chenyang Gu , Michael Lopez , Jiayi Ji , Juan Wisnivesky

RDD (Regression discontinuity design) is a widely used framework for identifying and estimating causal effects at the cutoff of a single running variable. In practice, however, decision-making often involves multiple thresholds and…

Uncertainties such as manufacturing tolerances cause performance variations in complex engineering systems, making robust design optimization (RDO) essential. However, simulation-based RDO faces high computational cost for statistical…

Optimization and Control · Mathematics 2026-02-10 Hyunho Jang , Dongjin Lee

We present simple low-level conditions for identification in regression discontinuity designs using a potential outcome framework for the manipulation of the running variable. Using this framework, we replace the existing identification…

Econometrics · Economics 2024-09-18 Takuya Ishihara , Masayuki Sawada

We develop a new framework for evaluating the total policy effect in regression discontinuity designs (RDD), incorporating both the direct effect of treatment on outcomes and the indirect effect arising from distortions in the running…

Econometrics · Economics 2025-12-01 Moyu Liao

In many supervised learning applications, the response consists of both continuous and binary outcomes. Studies have shown that jointly modeling such mixed-type responses can substantially improve predictive performance compared to separate…

Methodology · Statistics 2026-03-13 Yu Wang , Ran Jin , Lulu Kang

We extend the regression discontinuity (RD) design to settings where each unit's treatment status is an average or aggregate across multiple discontinuity events. Such situations arise in many studies where the outcome is measured at a…

Econometrics · Economics 2025-01-03 Kirill Borusyak , Matan Kolerman-Shemer

Personalized medicine seeks to identify the causal effect of treatment for a particular patient as opposed to a clinical population at large. Most investigators estimate such personalized treatment effects by regressing the outcome of a…

Machine Learning · Statistics 2021-09-02 Eric V. Strobl , Shyam Visweswaran

There is wide interest in studying how the distribution of a continuous response changes with a predictor. We are motivated by environmental applications in which the predictor is the dose of an exposure and the response is a health…

Methodology · Statistics 2018-05-10 Antonio Canale , Daniele Durante , David Dunson

Many empirical examples of regression discontinuity (RD) designs concern a continuous treatment variable, but the theoretical aspects of such models are less studied. This study examines the identification and estimation of the structural…

Econometrics · Economics 2022-07-19 Haitian Xie

Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal…

Methodology · Statistics 2026-01-21 Yu Luo , Kuan Liu , Ramandeep Singh , Daniel J. Graham