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Systems modeled by partial differential equations (PDEs) are at least as ubiquitous as systems that are by nature finite-dimensional and modeled by ordinary differential equations (ODEs). And yet, systematic and readily usable…

Optimization and Control · Mathematics 2025-09-11 Rafael Vazquez , Jean Auriol , Federico Bribiesca-Argomedo , Miroslav Krstic

In this paper we introduce a formalism that allows to describe the response of a part of a biochemical system in terms of renewal equations. In particular, we examine under which conditions the interactions between the different parts of a…

Analysis of PDEs · Mathematics 2023-09-06 E. Franco , B. Kepka , J. J. L. Velázquez

The dynamics of systems biological processes are usually modeled by a system of ordinary differential equations (ODEs) with many unknown parameters that need to be inferred from noisy and sparse measurements. Here, we introduce…

Quantitative Methods · Quantitative Biology 2022-02-04 Mitchell Daneker , Zhen Zhang , George Em Karniadakis , Lu Lu

Causal discovery is a data-driven paradigm for analyzing complex systems, while physics-based models, such as ordinary differential equations (ODEs), provide mechanistic structure for real-world dynamical processes. Integrating these…

Machine Learning · Computer Science 2026-05-21 Jianhong Chen , Naichen Shi , Xubo Yue

This letter presents a high-dimensional analysis of the training dynamics for a single-layer nonlinear contrastive learning model. The empirical distribution of the model weights converges to a deterministic measure governed by a…

Machine Learning · Computer Science 2024-06-12 Lineghuan Meng , Chuang Wang

This work concerns the exponential stabilization of underactuated linear homogeneous systems of m parabolic partial differential equations (PDEs) in cascade (reaction-diffusion systems), where only the first state is controlled either…

Optimization and Control · Mathematics 2023-10-19 Constantinos Kitsos , Emilia Fridman

Learning complex trajectories from demonstrations in robotic tasks has been effectively addressed through the utilization of Dynamical Systems (DS). State-of-the-art DS learning methods ensure stability of the generated trajectories;…

Robotics · Computer Science 2024-12-10 Andreas Sochopoulos , Michael Gienger , Sethu Vijayakumar

Fractional differential equations (FDEs) are an extension of the theory of fractional calculus. However, due to the difficulty in finding analytical solutions, there have not been extensive applications of FDEs until recent decades. With…

Numerical Analysis · Mathematics 2020-07-20 Nirupama Bhattacharya , Gabriel A. Silva

The interpretation of numerical methods, such as finite difference methods for differential equations, as point estimators suggests that formal uncertainty quantification can also be performed in this context. Competing statistical…

Other Statistics · Statistics 2019-09-24 Junyang Wang , Jon Cockayne , Chris J. Oates

The multiple futile cycle is an important building block in networks of chemical reactions arising in molecular biology. A typical process which it describes is the addition of n phosphate groups to a protein. It can be modelled by a system…

Molecular Networks · Quantitative Biology 2014-04-03 Juliette Hell , Alan D. Rendall

In this work, we are motivated by a recent variant of the nonlinear Schrodinger (NLS) equation describing cold, dilute atomic condensates with quantum fluctuation effects. Our goal is to develop robust numerical methods capable of…

Pattern Formation and Solitons · Physics 2026-04-01 Sun Lee , Panayotis G. Kevrekidis , Wenrui Hao

Equilibrium and nonequilibrium systems exhibit power-law singularities close to their critical and bifurcation points respectively. A recent study has shown that biochemical nonequilibrium models with positive feedback belong to the…

Quantitative Methods · Quantitative Biology 2019-06-12 Indrani Bose , Sayantari Ghosh

Computer algebra methods for analyzing reaction networks often rely on the assumption of mass-action kinetics, which transform the governing ODEs into polynomial systems amenable to techniques such as Gr\"obner basis computation and related…

Molecular Networks · Quantitative Biology 2025-11-19 Richard Golnik , Thomas Gatter , Peter F. Stadler , Nicola Vassena

Anticipating bifurcation-induced transitions in dynamical systems has gained relevance in various fields of the natural, social, and economic sciences. Before the annihilation of a system's equilibrium point by means of a bifurcation, the…

Dynamical Systems · Mathematics 2024-09-06 Andreas Morr , Keno Riechers , Leonardo Rydin Gorjão , Niklas Boers

Ordinary differential equations (ODEs) are widely used to describe the time evolution of natural phenomena across various scientific fields. Estimating the parameters of these systems from data is a challenging task, particularly when…

Numerical Analysis · Mathematics 2025-01-23 S. Syafiie , Aries Subiantoro , Vivi Andasari , Fernando Tadeo

Biochemical molecules interact through modification and binding reactions, giving raise to a combinatorial number of possible biochemical species. The time-dependent evolution of concentrations of the species is commonly described by a…

Molecular Networks · Quantitative Biology 2019-03-22 Andreea Beica , Jérôme Feret , Tatjana Petrov

Noise-induced transitions between metastable fixed points in systems evolving on multiple time scales are analyzed in situations where the time scale separation gives rise to a slow manifold with bifurcation. This analysis is performed…

Statistical Mechanics · Physics 2017-10-05 Tobias Grafke , Eric Vanden-Eijnden

Fast-slow dynamical systems have subsystems that evolve on vastly different timescales, and bifurcations in such systems can arise due to changes in any or all subsystems. We classify bifurcations of the critical set (the equilibria of the…

Dynamical Systems · Mathematics 2020-04-21 Karl Nyman , Peter Ashwin , Peter Ditlevsen

Statistical early warning signs can be used to identify an approaching bifurcation in stochastic dynamical systems and are now regularly employed in applications concerned with the identification of potential rapid, non-linear change or…

Dynamical Systems · Mathematics 2023-11-29 Lucia S. Layritz , Ilya Pavlyukevich , Anja Rammig , Christian Kuehn

There is growing interest in anticipating critical transitions in natural systems, often pursued through statistical detection of early warning signals associated with dynamical bifurcations. In stochastic dynamical systems, such signals…

Dynamical Systems · Mathematics 2026-03-30 Florian Suerhoff , Andreas Morr , Sebastian Bathiany , Niklas Boers , Christian Kuehn