Related papers: Allosteric Regulation by a Critical Membrane
Membranes containing a wide variety of ternary mixtures of high chain-melting temperature lipids, low chain-melting temperature lipids, and cholesterol undergo lateral phase separartion into coexisting liquid phases at a miscibility…
Allostery is a fundamental mechanism of protein regulation and is commonly interpreted as modulating enzymatic activity or product abundance. Here we show that this view is incomplete. Using a stochastic model of allosteric regulation…
Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice…
The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signaling to enzymology. Allosteric enzymes pervade metabolic…
We present a minimal model of plasma membrane heterogeneity that combines criticality with connectivity to cortical cytoskeleton. Our model is motivated by recent observations of micron-sized critical fluctuations in plasma membrane…
We present a neuronal network model inspired by the Ising model, where each neuron is a binary spin ($s_i = \pm1$) interacting with its neighbors on a 2D lattice. Updates are asynchronous and follow Metropolis dynamics, with a…
The ability to control the crystallization behaviour (including its absence) of particles, be they biomolecules such as globular proteins, inorganic colloids, nanoparticles, or metal atoms in an alloy, is of both fundamental and…
We study the critical behavior and the out-of-equilibrium dynamics of a two-dimensional Ising model with non-static interactions. In our model, bonds are dynamically changing according to a majority rule depending on the set of closest…
Much progress has been made in elucidating the inner workings of voltage-gated ion channels, but less understood is the influence of lipid rafts on gating kinetics. Here we propose that state-dependent channel affinity for different lipid…
A system defined by two coupled Ising models, with a bimodal random field acting in one of them, is investigated. The interactions among variables of each Ising system are infinite-ranged, a limit where mean field becomes exact. This model…
We perform large-scale computer simulations of an off-lattice two-dimensional model of active particles undergoing a motility-induced phase separation (MIPS) to investigate the systems critical behaviour close to the critical point of the…
Temperature estimation of interacting quantum many-body systems is both a challenging task and topic of interest in quantum metrology, given that critical behavior at phase transitions can boost the metrological sensitivity. Here we study…
Liquid-liquid phase separation has recently emerged as an important topic in the context of cellular organization. Within this context, there are multiple poorly understood features; for instance hints of critical behavior in the plasma…
We consider the critical behavior of two-dimensional layered Ising models where the exchange couplings between neighboring layers follow hierarchical sequences. The perturbation caused by the non-periodicity could be irrelevant, relevant or…
The understanding of dynamics and functioning of biological membranes and in particular of membrane embedded proteins is one of the most fundamental problems and challenges in modern biology and biophysics. In particular the impact of…
Lateral organization in the plane of the plasma membrane is an important driver of biological processes. The past dozen years have seen increasing experimental support for the notion that lipid organization plays an important role in…
Probabilistic cellular automata are prototypes of non equilibrium critical phenomena. This class of models includes among others the directed percolation problem (Domany Kinzel model) and the dynamical Ising model. The critical properties…
In this work we studied the critical behavior of the critical point as function of the number of nearest neighbors on two dimensional regular lattices. We performed numerical simulations on triangular, hexagonal and bilayer square lattices.…
Allosteric signaling in biological molecules, which may be viewed as specific action at a distance due to localized perturbation upon binding of ligands or changes in environmental cues, is pervasive in biology. Phenomenological MWC and KNF…
The scaling of the transition temperature into an ordered phase close to a quantum critical point as well as the order parameter fluctuations inside the quantum critical region provide valuable information about universal properties of the…