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Structural and dynamical fingerprints of evolutionary optimization in biological networks are still unclear. We here analyze the dynamics of genetic regulatory networks responsible for the regulation of cell cycle and cell differentiation…

Molecular Networks · Quantitative Biology 2016-06-22 N. Aral , A. Kabakcioglu

The notion of cellular stratified spaces was introduced in a joint work of the author with Basabe, Gonz{\'a}lez, and Rudyak with the aim of constructing a cellular model of the configuration space of a sphere. Although the original aim was…

Algebraic Topology · Mathematics 2016-09-16 Dai Tamaki

The coding mechanism of sensory memory on the neuron scale is one of the most important questions in neuroscience. We have put forward a quantitative neural network model, which is self organized, self similar, and self adaptive, just like…

Neural and Evolutionary Computing · Computer Science 2014-06-26 Peilei Liu , Ting Wang

Compositional Explanations is a method for identifying logical formulas of concepts that approximate the neurons' behavior. However, these explanations are linked to the small spectrum of neuron activations (i.e., the highest ones) used to…

Machine Learning · Computer Science 2023-10-31 Biagio La Rosa , Leilani H. Gilpin , Roberto Capobianco

A vast array of transformative technologies developed over the past decade has enabled measurement and perturbation at ever increasing scale, yet our understanding of many systems remains limited by experimental capacity. Overcoming this…

Quantitative Methods · Quantitative Biology 2020-12-25 Brian Cleary , Aviv Regev

Associative memory is a fundamental function in the brain. Here, we generalize the standard associative memory model to include long-range Hebbian interactions at the learning stage, corresponding to a large synaptic integration window. In…

Disordered Systems and Neural Networks · Physics 2021-12-21 Jianwen Zhou , Zijian Jiang , Tianqi Hou , Ziming Chen , K Y Michael Wong , Haiping Huang

Understanding the dynamics of large-scale brain models remains a central challenge due to the inherent complexity of these systems. In this work, we explore the emergence of complex spatiotemporal patterns in a large scale-brain model…

Neurons and Cognition · Quantitative Biology 2025-12-04 Rosa Maria Delicado , Gemma Huguet , Pau Clusella

Associative networks theory is increasingly providing tools to interpret update rules of artificial neural networks. At the same time, deriving neural learning rules from a solid theory remains a fundamental challenge. We make some steps in…

Neurons and Cognition · Quantitative Biology 2025-03-27 Daniele Lotito

A number of biological processes, such as embryo development, cancer metastasis or wound healing, rely on cells moving in concert. The mechanisms leading to the emergence of coordinated motion remain however largely unexplored. Although…

Cell Behavior · Quantitative Biology 2011-08-23 Alexandre J Kabla

A major challenge in neuroscience is posed by the need for relating the emerging dynamical features of brain activity with the underlying modular structure of neural connections, hierarchically organized throughout several scales. The…

Neurons and Cognition · Quantitative Biology 2016-06-03 Pablo Villegas , Jorge Hidalgo , Paolo Moretti , Miguel A. Muñoz

A systematic analysis of the cell behavior requires automated approaches for cell segmentation and tracking. While deep learning has been successfully applied for the task of cell segmentation, there are few approaches for simultaneous cell…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Katharina Löffler , Ralf Mikut

This paper describes a framework for modeling the interface between perception and memory on the algorithmic level of analysis. It is consistent with phenomena associated with many different brain regions. These include view-dependence (and…

Neural and Evolutionary Computing · Computer Science 2015-12-29 Joel Z. Leibo , Julien Cornebise , Sergio Gómez , Demis Hassabis

Carrier aggregation (CA) and small cells are two distinct features of next-generation cellular networks. Cellular networks with small cells take on a very heterogeneous characteristic, and are often referred to as HetNets. In this paper, we…

Information Theory · Computer Science 2016-11-17 Xingqin Lin , Jeffrey G. Andrews , Amitava Ghosh

Motivated by the question of how macromolecules assemble, the notion of an {\it assembly tree} of a graph is introduced. Given a graph $G$, the paper is concerned with enumerating the number of assembly trees of $G$, a problem that applies…

Combinatorics · Mathematics 2012-04-18 Andrew Vince , Miklos Bona

The response time of physical computational elements is finite, and neurons are no exception. In hierarchical models of cortical networks each layer thus introduces a response lag. This inherent property of physical dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-10-28 Paul Haider , Benjamin Ellenberger , Laura Kriener , Jakob Jordan , Walter Senn , Mihai A. Petrovici

We address the question of whether or not assembly bias arises in the absence of highly non-linear effects such as tidal stripping of halos near larger mass concentrations. Therefore, we use a simplified dynamical scheme where these effects…

Astrophysics · Physics 2009-11-13 Jose Ariel Keselman , Adi Nusser

The complexity of cellular automata is traditionally measured by their computational capacity. However, it is difficult to choose a challenging set of computational tasks suitable for the parallel nature of such systems. We study the…

Neural and Evolutionary Computing · Computer Science 2021-08-03 Barbora Hudcová , Tomáš Mikolov

Spontaneous, synchronous bursting of neural population is a widely observed phenomenon in nervous networks, which is considered important for functions and dysfunctions of the brain. However, how the global synchrony across a large number…

Neurons and Cognition · Quantitative Biology 2022-06-08 Satohiro Tajima , Takeshi Mita , Douglas J. Bakkum , Hirokazu Takahashi , Taro Toyoizumi

Biomolecular condensates self-assemble when proteins and nucleic acids spontaneously demix to form droplets within the crowded intracellular milieu. This simple mechanism underlies the formation of a wide variety of membraneless…

Statistical Mechanics · Physics 2021-06-30 William M. Jacobs

In this paper, we analyze the embedding cell method, an algorithm which has been developed for the numerical homogenization of metal-ceramic composite materials. We show the convergence of the iteration scheme of this algorithm and the…

Numerical Analysis · Mathematics 2016-12-20 Wolf-Patrick Düll , Bastian Hilder , Guido Schneider