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Signal transduction and cell function are governed by the spatiotemporal organization of membrane-associated molecules. Despite significant advances in visualizing molecular distributions by 3D light microscopy, cell biologists still have…

Quantitative Methods · Quantitative Biology 2023-04-14 Felix Y. Zhou , Andrew Weems , Gabriel M. Gihana , Bingying Chen , Bo-Jui Chang , Meghan Driscoll , Gaudenz Danuser

A new upscaling procedure that provides 1D representations of 2D mixing-limited reactive transport systems is developed and applied. A key complication with upscaled models in this setting is that the procedure must differentiate between…

Fluid Dynamics · Physics 2022-10-05 Ricardo H. Deucher , Louis J. Durlofsky

Recent advances in imaging technology now provide us with 3D images of developing organs. These can be used to extract 3D geometries for simulations of organ development. To solve models on growing domains, the displacement fields between…

Quantitative Methods · Quantitative Biology 2014-10-17 Clemens Arthur Schwaninger , Denis Menshykau , Dagmar Iber

We simulate convection near the solar surface, where the continuum optical depth is of order unity. Hence, to determine the radiative heating and cooling in the energy conservation equation, we must solve the radiative transfer equation…

Astrophysics · Physics 2007-05-23 Robert Stein , Aake Nordlund

A mathematical model of the distribution function for the discrete 3-disk is proposed in order to utilize in the statistical evolution equation of the 3-dimensional Universe. The model distribution is constructed based on analyses in known…

General Relativity and Quantum Cosmology · Physics 2015-12-14 Tetsuyuki Yukawa

During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases,…

Biological Physics · Physics 2016-07-07 Fabian Spill , Vivi Andasari , Michael Mak , Roger D. Kamm , Muhammad H. Zaman

Many cellular and subcellular biological processes can be described in terms of diffusing and chemically reacting species (e.g. enzymes). Such reaction-diffusion processes can be mathematically modelled using either deterministic…

Biological Physics · Physics 2015-06-26 Radek Erban , S. Jonathan Chapman

We use the evolving surface finite element method to solve a Cahn- Hilliard equation on an evolving surface with prescribed velocity. We start by deriving the equation using a conservation law and appropriate transport for- mulae and…

Numerical Analysis · Mathematics 2014-05-28 Charles M. Elliott , Thomas Ranner

We demonstrate a method for filtering images defined on curved surfaces embedded in 3D. Applications are noise removal and the creation of artistic effects. Our approach relies on in-surface diffusion: we formulate Weickert's edge/coherence…

Numerical Analysis · Mathematics 2014-04-08 Emma Naden , Thomas März , Colin B. Macdonald

Cell proliferation and diffusion can be modeled through reaction-diffusion systems describing the space-time evolution of a density variable. In this work, we present non-linear transformations of heat equation solutions to model cellular…

Chaotic Dynamics · Physics 2025-06-02 Preet Mishra , Shyam Kumar , Sapna Ratan Shah , R. K. Brojen Singh

We analyze the mixed frame equations of radiation hydrodynamics under the approximations of flux-limited diffusion and a thermal radiation field, and derive the minimal set of evolution equations that includes all terms that are of leading…

Astrophysics · Physics 2009-11-11 Mark R. Krumholz , Richard I. Klein , Christopher F. McKee , John Bolstad

It is known that solutions of nonlocal dispersal evolution equations do not become smoother in space as time elapses. This lack of space regularity would cause a lot of difficulties in studying transition fronts in nonlocal equations. In…

Analysis of PDEs · Mathematics 2015-11-13 Wenxian Shen , Zhongwei Shen

Conservative and non-conservative phase-field models are considered for the numerical simulation of lateral phase separation and coarsening in biological membranes. An unfitted finite element method is devised for these models to allow for…

Numerical Analysis · Mathematics 2019-01-08 Vladimir Yushutin , Annalisa Quaini , Sheereen Majd , Maxim Olshanskii

The design of an experiment, e.g., the setting of initial conditions, strongly influences the accuracy of the whole process of determining model parameters from data. We impose a sensitivity-based approach for choosing optimal design…

Numerical Analysis · Mathematics 2016-02-11 Stefan Kindermann , Stepan Papacek

Energy distributions of high frequency linear wave fields are often modelled in terms of flow or transport equations with ray dynamics given by a Hamiltonian vector field in phase space. Applications arise in underwater and room acoustics,…

Computational Physics · Physics 2014-08-12 David Chappell , Gregor Tanner , Niels Sondergaard , Dominik Loechel

We present and analyse a model for cell signalling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces, and both inter- and intracellular signalling. Using techniques from the theory of…

Analysis of PDEs · Mathematics 2020-03-12 Mariya Ptashnyk , Chandrasekhar Venkataraman

Anomalous diffusion, in particular subdiffusion, is frequently invoked as a mechanism of motion in dense biological media, and may have a significant impact on the kinetics of binding/unbinding events at the cellular level. In this work we…

Statistical Mechanics · Physics 2015-06-10 S. B. Yuste , E. Abad , K. Lindenberg

How can cells embedded into a gradient concentration triangulate the position of the source and migrate toward their final destination? The source triangulation requires to recover the three dimensional coordinates of the source from the…

Cell Behavior · Quantitative Biology 2020-10-07 Ulrich Dobramysl , David Holcman

We present a field theory to describe the composition of a surface spontaneously exchanging matter with its bulk environment. By only assuming matter conservation in the system, we show with extensive numerical simulations that, depending…

Biological Physics · Physics 2023-08-09 Nirvana Caballero , Karsten Kruse , Thierry Giamarchi

Neural representations of 3D data have been widely adopted across various applications, particularly in recent work leveraging coordinate-based networks to model scalar or vector fields. However, these approaches face inherent challenges,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Biao Zhang , Jing Ren , Peter Wonka