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Elucidating the architecture and dynamics of large scale genetic regulatory networks of cells is an important goal in systems biology. We study the system level dynamical properties of the genetic network of Escherichia coli that regulates…

Molecular Networks · Quantitative Biology 2008-02-29 Areejit Samal , Sanjay Jain

The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new…

Molecular Networks · Quantitative Biology 2011-08-26 Areejit Samal , Andreas Wagner , Olivier C. Martin

Networks are fundamental building blocks for representing data, and computations. Remarkable progress in learning in structurally defined (shallow or deep) networks has recently been achieved. Here we introduce evolutionary exploratory…

Neural and Evolutionary Computing · Computer Science 2019-11-05 Rise Ooi , Chao-Han Huck Yang , Pin-Yu Chen , Vìctor Eguìluz , Narsis Kiani , Hector Zenil , David Gomez-Cabrero , Jesper Tegnèr

An agent must try new behaviors to explore and improve. In high-stakes environments, an agent that violates safety constraints may cause harm and must be taken offline, curtailing any future interaction. Imitating old behavior is safe, but…

Artificial Intelligence · Computer Science 2026-04-17 Drew Prinster , Clara Fannjiang , Ji Won Park , Kyunghyun Cho , Anqi Liu , Suchi Saria , Samuel Stanton

Determining mechanistic models of gene regulation, especially underlying phenotypic variation, is a central goal of both mathematical biology and modern evolutionary biology. However, several challenges, involving both common…

Molecular Networks · Quantitative Biology 2025-11-04 Cody E. FitzGerald , Shelley Reich , Victor Agaba , Arjun Mathur , Michael S. Werner , Niall M. Mangan

The stochastic exploration of the configuration space and the exploitation of functional states underlie many biological processes. The evolutionary dynamics stands out as a remarkable example. Here, we introduce a novel formalism that…

Biological Physics · Physics 2024-01-23 Vito Dichio , Fabrizio De Vico Fallani

The quest to understand structure-function relationships in networks across scientific disciplines has intensified. However, the optimal network architecture remains elusive, particularly for complex information processing. Therefore, we…

Adaptation and Self-Organizing Systems · Physics 2024-03-27 Manish Yadav , Sudeshna Sinha , Merten Stender

We address a primary question of computational as well as biological research on evolution: How can an exploration strategy adapt in such a way as to exploit the information gained about the problem at hand? We first introduce an integrated…

Biological Physics · Physics 2007-05-23 Marc Toussaint

Adaptation plays a fundamental role in shaping the structure of a complex network and improving its functional fitting. Even when increasing the level of synchronization in a biological system is considered as the main driving force for…

Physics and Society · Physics 2018-04-11 Vanesa Avalos-Gaytán , J. A. Almendral , I. Leyva , F. Battiston , V. Nicosia , V. Latora , S. Boccaletti

Robustness to genetic or environmental disturbances is often considered as a key property of living systems. Yet, in spite of being discussed since the 1950s, how robustness emerges from the complexity of genetic architectures and how it…

Populations and Evolution · Quantitative Biology 2022-03-31 Arnaud Le Rouzic

In this paper we investigate networks whose evolution is governed by the interaction of a random assembly process and an optimization process. In the first process, new nodes are added one at a time and form connections to randomly selected…

Disordered Systems and Neural Networks · Physics 2011-05-16 Markus Brede

Adaptive networks are a novel class of dynamical networks whose topologies and states coevolve. Many real-world complex systems can be modeled as adaptive networks, including social networks, transportation networks, neural networks and…

Social and Information Networks · Computer Science 2017-05-29 Hiroki Sayama , Irene Pestov , Jeffrey Schmidt , Benjamin James Bush , Chun Wong , Junichi Yamanoi , Thilo Gross

This paper presents a real-time simulation involving ''protozoan-like'' cells that evolve by natural selection in a physical 2D ecosystem. Selection pressure is exerted via the requirements to collect mass and energy from the surroundings…

Neural and Evolutionary Computing · Computer Science 2023-05-23 Dylan Cope

An organism that is newly introduced into an existing population has a survival probability that is dependent on both the population density of its environment and the competition it experiences with the members of that population.…

Populations and Evolution · Quantitative Biology 2024-12-17 Jason M. Gray , Rowan J. Barker-Clarke , Jacob G. Scott , Michael Hinczewski

Biological nervous systems consist of networks of diverse, sophisticated information processors in the form of neurons of different classes. In most artificial neural networks (ANNs), neural computation is abstracted to an activation…

Neural and Evolutionary Computing · Computer Science 2023-06-12 Joachim Winther Pedersen , Sebastian Risi

We suggest to simulate evolution of complex organisms constrained by the sole requirement of robustness in their expression patterns. This scenario is illustrated by evolving discrete logical networks with epigenetic properties. Evidence…

Statistical Mechanics · Physics 2007-05-23 Stefan Bornholdt , Kim Sneppen

Continuous adaptation allows survival in an ever-changing world. Adjustments in the synaptic coupling strength between neurons are essential for this capability, setting us apart from simpler, hard-wired organisms. How these changes can be…

Neurons and Cognition · Quantitative Biology 2021-01-06 Jakob Jordan , Maximilian Schmidt , Walter Senn , Mihai A. Petrovici

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

Statistical Mechanics · Physics 2009-09-30 Zoran Levnajić

We present and discuss the results of an experimental analysis in the design of Boolean networks by means of genetic algorithms. A population of networks is evolved with the aim of finding a network such that the attractor it reaches is of…

Neural and Evolutionary Computing · Computer Science 2011-02-01 Andrea Roli , Cristian Arcaroli , Marco Lazzarini , Stefano Benedettini

Ensuring sufficient exploration is a central challenge when training meta-reinforcement learning (meta-RL) agents to solve novel environments. Conventional solutions to the exploration-exploitation dilemma inject explicit incentives such as…

Machine Learning · Computer Science 2025-08-05 Micah Rentschler , Jesse Roberts