The stochastic exploration of the configuration space and the exploitation of functional states underlie many biological processes. The evolutionary dynamics stands out as a remarkable example. Here, we introduce a novel formalism that mimics evolution and encodes a general exploration-exploitation dynamics for biological networks. We apply it to the brain wiring problem, focusing on the maturation of that of the nematode C. elegans. We demonstrate that a parsimonious maxent description of the adult brain combined with our framework is able to track down the entire developmental trajectory.
@article{arxiv.2306.17300,
title = {The exploration-exploitation paradigm for networked biological systems},
author = {Vito Dichio and Fabrizio De Vico Fallani},
journal= {arXiv preprint arXiv:2306.17300},
year = {2024}
}