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Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid re-arrangements of the medium constantly change the effective diffusivity felt…

Statistical Mechanics · Physics 2019-11-13 Yann Lanoiselée , Nicolas Moutal , Denis S. Grebenkov

The reaction-diffusion master equation (RDME) is a model that allows for efficient on-lattice simulation of spatially resolved stochastic chemical kinetics. Compared to off-lattice hard-sphere simulations with Brownian Dynamics (BD) or…

Numerical Analysis · Mathematics 2017-09-06 Stefan Hellander , Andreas Hellander , Linda Petzold

An efficient technique to simulate turbulent particle-laden flow at high mass loadings within the four-way coupled simulation regime is presented. The technique implements large eddy simulation, discrete phase simulation, a deterministic…

Fluid Dynamics · Physics 2017-09-13 Derrick O. Njobuenwu , Michael Fairweather

In recent years, several particle-based stochastic simulation algorithms (PSSA) have been developed to study the spatially resolved dynamics of biochemical networks at a molecular scale. A challenge all these approaches have to address is…

Quantitative Methods · Quantitative Biology 2011-07-04 Thorsten Prüstel , Martin Meier-Schellersheim

Product formulas can be used to simulate Hamiltonian dynamics on a quantum computer by approximating the exponential of a sum of operators by a product of exponentials of the individual summands. This approach is both straightforward and…

Quantum Physics · Physics 2019-09-04 Andrew M. Childs , Aaron Ostrander , Yuan Su

In recent years modelling crowd and evacuation dynamics has become very important, with increasing huge numbers of people gathering around the world for many reasons and events. The fact that our global population grows dramatically every…

Physics and Society · Physics 2015-01-28 Mohamed H. Dridi

Complex biological and physical transport processes are often described through systems of interacting particles. Excluded-volume effects on these transport processes are well studied, however the interplay between volume exclusion and…

Statistical Mechanics · Physics 2018-06-27 Daniel Wilson , Helen Byrne , Maria Bruna

We consider a system of classical Brownian particles interacting via a smooth long-range potential in the mean-field regime, and we analyze the propagation of chaos in form of sharp, uniform-in-time estimates on many-particle correlation…

Analysis of PDEs · Mathematics 2025-02-18 Armand Bernou , Mitia Duerinckx

Evacuation plans have been historically used as a safety measure for the construction of buildings. The existing crowd simulators require fully-modeled 3D environments and enough time to prepare and simulate scenarios, where the…

Multiagent Systems · Computer Science 2020-10-02 Estevso Testa , Rodrigo C. Barros , Soraia Raupp Musse

A simple and efficient algorithm of the molecular-dynamics simulation of the hard disk system based on the Event-Driven method is developed. From the analysis of algorithm, the complexity is O(log N) per 1 event, and the constant…

Computational Physics · Physics 2009-10-31 Masaharu Isobe

The efficiency of atomic simulations of materials and molecules can rapidly deteriorate when large free energy barriers exist between local minima. We propose smooth basin classification, a universal method to define reaction coordinates…

Using Brownian dynamics simulations, the motion of active Brownian particles (ABPs) in the presence of fuel (or 'food') sources is studied. It is an established fact that within confined stationary systems, the activity of ABPs generates…

Biological Physics · Physics 2020-07-01 Holger Merlitz , Hidde Derk Vuijk , Rene Wittmann , Abhinav Sharma , Jens-Uwe Sommer

We present a new algorithm to simulate dynamic group behaviors for interactive multi-agent crowd simulation. Our approach is general and makes no assumption about the environment, shape, or size of the groups. We use the least effort…

Multiagent Systems · Computer Science 2016-02-12 Liang He , Jia Pan , Sahil Narang , Wenping Wang , Dinesh Manocha

Diffusion in bidisperse Brownian hard-sphere suspensions is studied by Stokesian Dynamics (SD) computer simulations and a semi-analytical theoretical scheme for colloidal short-time dynamics, based on Beenakker and Mazur's method [Physica…

Soft Condensed Matter · Physics 2015-05-06 Mu Wang , Marco Heinen , John F. Brady

We present a new Eulerian framework for the computation of turbulent compressible multiphase channel flows, specifically to assess turbulence modulation by dispersed particulate matter in dilute concentrations but with significant mass…

Fluid Dynamics · Physics 2025-08-12 Ajay Dhankarghare , Yuval Dagan

In the coarse grained Brownian Dynamics simulation method the many solvent molecules are replaced by random thermal kicks and an effective friction acting on the particles of interest. For Brownian Dynamics the friction has to be so strong…

Biomolecules · Quantitative Biology 2015-05-13 Uwe Winter , Tihamer Geyer

Crowd simulation models are used to assess the performance and safety of crowd systems. In some systems, wheelchairs and other moving objects are present in the crowd. The different size and speed of the wheelchairs could significantly…

Multiagent Systems · Computer Science 2020-10-02 Siamak Sarmady , Fazilah Haron , Abdullah Zawawi Talib

Simulation of biomolecular networks is now indispensable for studying biological systems, from small reaction networks to large ensembles of cells. Here we present a novel approach for stochastic simulation of networks embedded in the…

Quantitative Methods · Quantitative Biology 2016-09-28 Margaritis Voliotis , Philipp Thomas , Ramon Grima , Clive G. Bowsher

The analysis of non-equilibrium steady states of biochemical reaction networks relies on finding the configurations of fluxes and chemical potentials satisfying stoichiometric (mass balance) and thermodynamic (energy balance) constraints.…

Molecular Networks · Quantitative Biology 2011-07-13 Daniele De Martino , Matteo Figliuzzi , Andrea De Martino , Enzo Marinari

Fluctuating hydrodynamics based techniques have been developed in recent years for the simulation of Brownian motion of particles. These mesoscale simulation tools are viable approaches for problems where molecular dynamics simulations may…

Fluid Dynamics · Physics 2014-02-11 Yong Chen , Neelesh A. Patankar
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