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We study the problem of controlling a general complex network towards an assigned synchronous evolution, by means of a pinning control strategy. We define the pinning-controllability of the network in terms of the spectral properties of an…

Disordered Systems and Neural Networks · Physics 2007-05-23 Francesco Sorrentino , Mario di Bernardo , Franco Garofalo , Guanrong Chen

One of the characteristic features of genetic networks is their inherent robustness, that is, their ability to retain functionality in spite of the introduction of random errors. In this paper, we seek to better understand how robustness is…

Molecular Networks · Quantitative Biology 2009-04-29 Arnab Bhattacharyya , Bernhard Haeupler

Understanding how transient dynamics unfold in response to localized inputs is central to predicting and controlling signal propagation in network systems, including neural processing, epidemic intervention, and power-grid resilience.…

Physics and Society · Physics 2025-10-23 Xiaoge Bao , Wei P. Dai , Jan Nagler , Wei Lin

One of the basic frameworks in science views behavioral products as a process within a dynamic system. The mechanism might be seen as a representation of many instances of centralized control in real time. Many real systems, however,…

Dynamical Systems · Mathematics 2019-08-19 Chulwook Park

Directed networks are essential for representing complex systems, capturing the asymmetry of interactions in fields such as neuroscience, transportation, and social networks. Directionality reveals how influence, information, or resources…

Disordered Systems and Neural Networks · Physics 2024-12-23 Marián Boguñá , M. Ángeles Serrano

Two different types of directed networks are investigated, transcriptional regulation networks and neural networks. The directed network structure are studied and also shown to reflect the different processes taking place on the networks.…

Disordered Systems and Neural Networks · Physics 2016-08-16 Andreas Grönlund

Understanding how the structure of within-system interactions affects the dynamics of the system is important in many areas of science. We extend a network dynamics modeling platform DSGRN, which combinatorializes both dynamics and…

Dynamical Systems · Mathematics 2022-05-17 Bree Cummins , Marcio Gameiro , Tomas Gedeon , Shane Kepley , Konstantin Mischaikow , Lun Zhang

A biological regulatory network can be modeled as a discrete function that contains all available information on network component interactions. From this function we can derive a graph representation of the network structure as well as of…

Discrete Mathematics · Computer Science 2009-10-09 Heike Siebert

Oscillatory dynamics are common features of complex networks, often playing essential roles in regulating function. Across scales from gene regulatory networks to ecosystems, delayed feedback mechanisms are key drivers of system-scale…

Disordered Systems and Neural Networks · Physics 2026-03-06 Shijie Liu , Jinliang Han , Jianming Liu , Tim Rogers , Yongzheng Sun

The relationship between network topology and system dynamics has significant implications for unifying our understanding of the interplay among metabolic, gene-regulatory, and ecosystem network architecures. Here we analyze the stability…

Populations and Evolution · Quantitative Biology 2015-06-17 Cameron Smith , Raymond S. Puzio , Aviv Bergman

From gene regulatory networks to mutualistic networks, controlling a single node in the network topology can transform these complex dynamical systems from undesirable states to desirable ones. Corresponding methods have been well-studied…

Dynamical Systems · Mathematics 2025-02-26 Nan Dong , An Zeng , Honggang Li

To understand the structural dynamics of a large-scale social, biological or technological network, it may be useful to discover behavioral roles representing the main connectivity patterns present over time. In this paper, we propose a…

Social and Information Networks · Computer Science 2012-03-13 Ryan Rossi , Brian Gallagher , Jennifer Neville , Keith Henderson

Despite their widespread utility across domains, basic network models face fundamental limitations when applied to complex biological systems, particularly in neuroscience. This paper critically examines these limitations and explores…

Other Quantitative Biology · Quantitative Biology 2024-11-07 Luiz Pessoa

Our ability to control complex systems is a fundamental challenge of contemporary science. Recently introduced tools to identify the driver nodes, nodes through which we can achieve full control, predict the existence of multiple control…

Controlling real-world networked systems, including ecological, biomedical, and engineered networks that exhibit higher-order interactions, remains challenging due to inherent nonlinearities and large system scales. Despite extensive…

Optimization and Control · Mathematics 2026-03-23 Joshua Pickard , Xin Mao , Can Chen

This paper studies the structural controllability of a class of uncertain switched linear systems, where the parameters of subsystems state matrices are either unknown or zero. The structural controllability is a generalization of the…

Systems and Control · Computer Science 2013-08-27 Xiaomeng Liu , Hai Lin , Ben M. Chen

The two most fundamental processes describing change in biology, development and evolu-tion, occur over drastically different timescales, difficult to reconcile within a unified framework. Development involves temporal sequences of cell…

Biological Physics · Physics 2020-09-08 Enrico Borriello , Sara I. Walker , Manfred D. Laubichler

A major achievement in the study of complex networks is the observation that diverse systems, from sub-cellular biology to social networks, exhibit universal topological characteristics. Yet this universality does not naturally translate to…

Physics and Society · Physics 2018-01-29 Chittaranjan Hens , Uzi Harush , Reuven Cohen , Baruch Barzel

We study genetic networks that produce many species of non-coding RNA molecules that are present at a moderate density, as typically exists in the cell. The associations of the many species of these RNA are modeled physically, taking into…

Genomics · Quantitative Biology 2014-09-08 J. M. Deutsch

Pinning control on complex dynamical networks has emerged as a very important topic in recent trends of control theory due to the extensive study of collective coupled behaviors and their role in physics, engineering and biology. In…

Optimization and Control · Mathematics 2016-01-25 Stephane Chretien , Sebastien Darses
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