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We report on a molecular simulation method which captures the self-assembly of cationic lipid-DNA (CL-DNA) gene delivery complexes. Computational efficiency required for large length- and time-scale simulations is achieved through a…

Soft Condensed Matter · Physics 2007-05-23 Oded Farago , Niels Grønbech-Jensen , Philip Pincus

Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Multistep catalytic reactions use two different catalysts for the $A\to B$ and the subsequent $B\to C$ reaction, respectively. Often the employed catalysts are chemically incompatible, such as acid-base systems, which prohibits simple…

Computational Physics · Physics 2021-09-10 Gabriel Sitaru , Stephan Gekle

Different numerical mappings of the DNA sequences have been studied using a new cluster-scaling method and the well known spectral methods. It is shown, in particular, that the nucleotide sequences in DNA molecules have robust…

Biomolecules · Quantitative Biology 2018-01-31 A. Bershadskii

Computational fluid dynamics is both a thriving research field and a key tool for advanced industry applications. The central challenge is to simulate turbulent flows in complex geometries, a compute-power intensive task due to the large…

Fast and accurate generation of molecular conformers is desired for downstream computational chemistry and drug discovery tasks. Currently, training and sampling state-of-the-art diffusion or flow-based models for conformer generation…

In this work, we introduce a flow based machine learning approach, called reaction coordinate (RC) flow, for discovery of low-dimensional kinetic models of molecular systems. The RC flow utilizes a normalizing flow to design the coordinate…

Machine Learning · Computer Science 2023-09-13 Hao Wu , Frank Noé

2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time-consuming, motivating the reconstruction of the velocity field from undersampled…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 Pablo Arratia , Martin J. Graves , Mary McLean , Carolin Pirkl , Carola-Bibiane Schönlieb , Timo Schirmer , Florian Wiesinger , Matthias J. Ehrhardt

Among the unsolved problems in computational biology, protein folding is one of the most interesting challenges. To study this folding, tools like neural networks and genetic algorithms have received a lot of attention, mainly due to the…

Biomolecules · Quantitative Biology 2016-08-23 Jacques M. Bahi , Nathalie Côté , Christophe Guyeux , Michel Salomon

We study the effect of fluid flow on three-dimensional (3D) dendrite growth using a phase-field model on an adaptive finite element grid. In order to simulate 3D fluid flow, we use an averaging method for the flow problem coupled to the…

Materials Science · Physics 2009-11-07 Jun-Ho Jeong , Nigel Goldenfeld , Jonathan A. Dantzig

Stochasticity plays important roles in reaction systems. Vector fields of probability flux and velocity characterize time-varying and steady-state properties of these systems, including high probability paths, barriers, checkpoints among…

Molecular Networks · Quantitative Biology 2018-12-05 Anna Terebus , Chun Liu , Jie Liang

Current feed-forward 3D/4D reconstruction systems rely on dense geometry and pose supervision -- expensive to obtain at scale and particularly scarce for dynamic real-world scenes. We present Flow3r, a framework that augments visual…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Zhongxiao Cong , Qitao Zhao , Minsik Jeon , Shubham Tulsiani

The reconstruction of unsteady flow fields from limited measurements is a challenging and crucial task for many engineering applications. Machine learning models are gaining popularity for solving this problem due to their ability to learn…

Fluid Dynamics · Physics 2026-01-09 Marc Amorós-Trepat , Luis Medrano-Navarro , Qiang Liu , Luca Guastoni , Nils Thuerey

Holistic understanding of multiphase reactive flow mechanisms such as CO$_2$ dissolution, multiphase displacement, and snap-off events are vital for optimisation of large-scale industrial operations like CO$_2$ sequestration, enhanced oil…

Fluid Dynamics · Physics 2021-03-08 Alexandros Patsoukis Dimou , Hannah P. Menke , Julien Maes

The flow of viscoelastic fluids in porous media is encountered in many practical applications, such as in the enhanced oil recovery process or in the groundwater remediation. Once the flow rate exceeds a critical value in such flows, an…

Fluid Dynamics · Physics 2022-09-28 A. Chauhan , S. Gupta , C. Sasmal

Modern technology for producing extremely bright and coherent X-ray laser pulses provides the possibility to acquire a large number of diffraction patterns from individual biological nanoparticles, including proteins, viruses, and DNA.…

Methodology · Statistics 2018-07-11 Stefan Engblom , Carl Nettelblad , Jing Liu

We study the flow of a shear-thinning, chemically-reacting fluid that could be used to model the flow of the synovial fluid. The actual geometry where the flow of the synovial fluid takes place is very complicated, and therefore the…

Numerical Analysis · Computer Science 2014-09-01 Craig Bridges , Satish Karra , K. R. Rajagopal

This article deals with approximating steady-state particle-resolved fluid flow around a fixed particle of interest under the influence of randomly distributed stationary particles in a dispersed multiphase setup using Convolutional Neural…

Fluid Dynamics · Physics 2021-10-25 Bhargav Sriram Siddani , S. Balachandar , Ruogu Fang

We study the collision probability $p$ of particles advected by open flows displaying chaotic advection. We show that $p$ scales with the particle size $\delta$ as a power law whose coefficient is determined by the fractal dimensions of the…

Chaotic Dynamics · Physics 2012-01-27 Alessandro P. S. de Moura

We discuss, in this paper, the dynamical properties of extremely diluted, non-monotonic neural networks. Assuming parallel updating and the Hebb prescription for the synaptic connections, a flow equation for the macroscopic overlap is…

Disordered Systems and Neural Networks · Physics 2009-11-07 M. S. Mainieri , R. Erichsen