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Several methods are available for the detection of covarying positions from a multiple sequence alignment (MSA). If the MSA contains a large number of sequences, information about the proximities between residues derived from covariation…

Quantitative Methods · Quantitative Biology 2014-04-29 Greg W. Clark , Sharon H. Ackerman , Elisabeth R. Tillier , Domenico L. Gatti

Principal component analysis (PCA) is a widely used method for data processing, such as for dimension reduction and visualization. Standard PCA is known to be sensitive to outliers, and thus, various robust PCA methods have been proposed.…

Machine Learning · Statistics 2020-08-11 Keishi Sando , Hideitsu Hino

This paper presents a comprehensive overview of several multidimensional reduction methods focusing on Multidimensional Principal Component Analysis (MPCA), Multilinear Orthogonal Neighborhood Preserving Projection (MONPP), Multidimensional…

Numerical Analysis · Mathematics 2026-01-05 Mohamed El Guide , Alaa El Ichi , Khalide Jbilou , Lothar Reichel , Hessah Alqahtani

This paper introduces a multiscale analysis based on optimal piecewise linear approximations of time series. An optimality criterion is formulated and on its base a computationally effective algorithm is constructed for decomposition of a…

Data Analysis, Statistics and Probability · Physics 2007-05-23 I. Zaliapin , A. Gabrielov , V. Keilis-Borok

Matrix factor model has been growing popular in scientific fields such as econometrics, which serves as a two-way dimension reduction tool for matrix sequences. In this article, we for the first time propose the matrix elliptical factor…

Methodology · Statistics 2022-03-29 ZeYu Li , Yong He , Xinbing Kong , Xinsheng Zhang

We develop a new method for multivariate scalar on multidimensional distribution regression. Traditional approaches typically analyze isolated univariate scalar outcomes or consider unidimensional distributional representations as…

Methodology · Statistics 2023-10-17 Rahul Ghosal , Marcos Matabuena

Causal mediation analysis (CMA) is a powerful method to dissect the total effect of a treatment into direct and mediated effects within the potential outcome framework. This is important in many scientific applications to identify the…

Machine Learning · Computer Science 2023-06-14 Ziyang Jiang , Yiling Liu , Michael H. Klein , Ahmed Aloui , Yiman Ren , Keyu Li , Vahid Tarokh , David Carlson

Quantile regression permits describing how quantiles of a scalar response variable depend on a set of predictors. Because a unique definition of multivariate quantiles is lacking, extending quantile regression to multivariate responses is…

Methodology · Statistics 2021-04-22 Silvia Columbu , Paolo Frumento , Matteo Bottai

Canonical Correlation Analysis (CCA) is a classical tool for finding correlations among the components of two random vectors. In recent years, CCA has been widely applied to the analysis of genomic data, where it is common for researchers…

Machine Learning · Computer Science 2012-06-22 Sivaraman Balakrishnan , Kriti Puniyani , John Lafferty

Methodologies for multidimensionality reduction aim at discovering low-dimensional manifolds where data ranges. Principal Component Analysis (PCA) is very effective if data have linear structure. But fails in identifying a possible…

Numerical Analysis · Mathematics 2021-01-14 Alberto García-González , Antonio Huerta , Sergio Zlotnik , Pedro Díez

These notes are an overview of some classical linear methods in Multivariate Data Analysis. This is a good old domain, well established since the 60's, and refreshed timely as a key step in statistical learning. It can be presented as part…

Numerical Analysis · Mathematics 2023-05-25 Alain Franc

Identifying low-dimensional latent structures within high-dimensional data has long been a central topic in the machine learning community, driven by the need for data compression, storage, transmission, and deeper data understanding.…

Machine Learning · Statistics 2025-03-28 Ye Tian , Sanyou Wu , Long Feng

Canonical Correlation Analysis (CCA) is a widely used spectral technique for finding correlation structures in multi-view datasets. In this paper, we tackle the problem of large scale CCA, where classical algorithms, usually requiring…

Machine Learning · Statistics 2015-06-29 Zhuang Ma , Yichao Lu , Dean Foster

Multilinear Principal Component Analysis (MPCA) is an important tool for analyzing tensor data. It performs dimension reduction similar to PCA for multivariate data. However, standard MPCA is sensitive to outliers. It is highly influenced…

Methodology · Statistics 2026-03-18 Mehdi Hirari , Fabio Centofanti , Mia Hubert , Stefan Van Aelst

Statistical inference in high-dimensional settings is challenging when standard unregularized methods are employed. In this work, we focus on the case of multiple correlated proportions for which we develop a Bayesian inference framework.…

Methodology · Statistics 2025-06-23 Max Westphal

We propose Deep Multiset Canonical Correlation Analysis (dMCCA) as an extension to representation learning using CCA when the underlying signal is observed across multiple (more than two) modalities. We use deep learning framework to learn…

Machine Learning · Computer Science 2023-02-09 Krishna Somandepalli , Naveen Kumar , Ruchir Travadi , Shrikanth Narayanan

Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single…

Applications · Statistics 2017-03-22 Hélène Ruffieux , Anthony C. Davison , Jörg Hager , Irina Irincheeva

The task of multi-objective alignment aims at balancing and controlling the different alignment objectives (e.g., helpfulness, harmlessness and honesty) of large language models to meet the personalized requirements of different users.…

Computation and Language · Computer Science 2024-08-12 Tingchen Fu , Yupeng Hou , Julian McAuley , Rui Yan

Modern high-throughput biomedical devices routinely produce data on a large scale, and the analysis of high-dimensional datasets has become commonplace in biomedical studies. However, given thousands or tens of thousands of measured…

Methodology · Statistics 2022-02-28 Vladimir Vutov , Thorsten Dickhaus

Principal component analysis (PCA) is an important tool in exploring data. The conventional approach to PCA leads to a solution which favours the structures with large variances. This is sensitive to outliers and could obfuscate interesting…

Methodology · Statistics 2015-06-16 A. A. Akinduko , A. N. Gorban
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