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Understanding and extracting the patterns of microscopy images has been a major challenge in the biomedical field. Although trained scientists can locate the proteins of interest within a human cell, this procedure is not efficient and…

Computer Vision and Pattern Recognition · Computer Science 2020-06-09 Hanke Chen

Cryo-EM is a vital technique for determining 3D structure of biological molecules such as proteins and viruses. The cryo-EM reconstruction problem is challenging due to the high noise levels, the missing poses of particles, and the…

Quantitative Methods · Quantitative Biology 2024-06-05 Larissa de Ruijter , Gabriele Cesa

Modern approach to artificial intelligence (AI) aims to design algorithms that learn directly from data. This approach has achieved impressive results and has contributed significantly to the progress of AI, particularly in the sphere of…

Machine Learning · Computer Science 2024-03-20 Alhassan Mumuni , Fuseini Mumuni

The implementation of deep learning algorithms has brought new perspectives to plankton ecology. Emerging as an alternative approach to established methods, deep learning offers objective schemes to investigate plankton organisms in diverse…

Introduction: The extracellular matrix (ECM) is a networkof proteins and carbohydrates that has a structural and bio-chemical function. The ECM plays an important role in dif-ferentiation, migration and signaling. Several studies…

Quantitative Methods · Quantitative Biology 2022-02-17 Mohamed Ghafoor , Anh Nguyen

Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to its partially coherent illumination and common path…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Yuheng Jiao , Yuchen R. He , Mikhail E. Kandel , Xiaojun Liu , Wenlong Lu , Gabriel Popescu

Deep learning has significantly accelerated drug discovery, with 'chemical language' processing (CLP) emerging as a prominent approach. CLP learns from molecular string representations (e.g., Simplified Molecular Input Line Entry Systems…

Biomolecules · Quantitative Biology 2025-01-13 Rıza Özçelik , Francesca Grisoni

Particle tracking is a fundamental task in digital microscopy. Recently, machine-learning approaches have made great strides in overcoming the limitations of more classical approaches. The training of state-of-the-art machine-learning…

Macromolecules change their shape (conformation) in the process of carrying out their functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of macromolecules (single particles) is a powerful and general…

Biomolecules · Quantitative Biology 2022-11-22 Bogdan Toader , Fred J. Sigworth , Roy R. Lederman

Deep learning has become very popular for tasks such as predictive modeling and pattern recognition in handling big data. Deep learning is a powerful machine learning method that extracts lower level features and feeds them forward for the…

Machine Learning · Computer Science 2018-03-07 Steven Young , Tamer Abdou , Ayse Bener

Many important physical processes have dynamics that are too complex to completely model analytically. Optimisation of such processes often relies on intuition, trial-and-error, or the construction of empirical models. Machine learning…

Despite its potential for label-free particle diagnostics, holographic microscopy is limited by specialized processing methods that struggle to generalize across diverse settings. We introduce a deep learning architecture leveraging human…

Optics · Physics 2024-11-26 Shyam Kumar , Jiarong Hong

Recognizing toponyms and resolving them to their real-world referents is required for providing advanced semantic access to textual data. This process is often hindered by the high degree of variation in toponyms. Candidate selection is the…

Computation and Language · Computer Science 2020-09-23 Mariona Coll Ardanuy , Kasra Hosseini , Katherine McDonough , Amrey Krause , Daniel van Strien , Federico Nanni

Direct detector device (DDD) cameras have revolutionized single particle electron cryomicroscopy (cryo-EM). In addition to an improved camera detective quantum efficiency, acquisition of DDD movies allows for correction of movement of the…

Quantitative Methods · Quantitative Biology 2015-11-23 John L. Rubinstein , Marcus A. Brubaker

A key question for machine learning approaches in particle physics is how to best represent and learn from collider events. As an event is intrinsically a variable-length unordered set of particles, we build upon recent machine learning…

High Energy Physics - Phenomenology · Physics 2020-04-17 Patrick T. Komiske , Eric M. Metodiev , Jesse Thaler

Preprocessing pipelines in deep learning aim to provide sufficient data throughput to keep the training processes busy. Maximizing resource utilization is becoming more challenging as the throughput of training processes increases with…

Machine Learning · Computer Science 2022-03-28 Alexander Isenko , Ruben Mayer , Jeffrey Jedele , Hans-Arno Jacobsen

Electron cryo-microscopy (cryo-EM) produces three-dimensional (3D) maps of the electrostatic potential of biological macromolecules, including proteins. Along with knowledge about the imaged molecules, cryo-EM maps allow de novo atomic…

Quantitative Methods · Quantitative Biology 2023-02-09 Kiarash Jamali , Dari Kimanius , Sjors H. W. Scheres

The availability of a tremendous amount of seismic data demands seismological researchers to analyze seismic phases efficiently. Recently, deep learning algorithms exhibit a powerful capability of detecting and picking on P- and S-wave…

Geophysics · Physics 2019-10-22 Congcong Yuan , Jie Zhang

The process monitoring task is characterized by stringent demands for accuracy and efficiency. Current transformer-based methods, characterized by self-attention for temporal fusion, exhibit limitations in accurately understanding the…

Artificial Intelligence · Computer Science 2026-01-06 Hao Wang , Zhichao Chen , Licheng Pan , Xiaoyu Jiang , Yichen Song , Qunshan He , Xinggao Liu

Deep neural networks have rightfully won the place of one of the most accurate analysis tools in high energy physics. In this paper we will cover several methods of improving the performance of a deep neural network in a classification task…

Data Analysis, Statistics and Probability · Physics 2021-09-20 Lev Dudko , Petr Volkov , Georgii Vorotnikov , Andrei Zaborenko
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