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Chemotaxis of the bacterium Escherichia coli is well understood in shallow chemical gradients, but its swimming behavior remains difficult to interpret in steep gradients. By focusing on single-cell trajectories from simulations, we…

Cell Behavior · Quantitative Biology 2018-02-14 Gabriele Micali , Remy Colin , Victor Sourjik , Robert G. Endres

In this work we upscale a prototypical kinetic transport equation which models a cell population moving in a fibrous environment with a chemo- or haptotactic signal influencing both the direction and the magnitude of the cell velocity. The…

Analysis of PDEs · Mathematics 2021-09-30 Anna Zhigun , Christina Surulescu

Bacterial chemotaxis for E.coli is controlled by methylation of chemoreceptors, which in a biochemical pathway regulates the concentration of the CheY-P protein that finally controls the tumbling rate. As a consequence, the tumbling rate…

Soft Condensed Matter · Physics 2025-04-23 Manuel Mayo , Rodrigo Soto

In this paper, we propose a numerical scheme to solve the kinetic model for chemotaxis phenomena. Formally, this scheme is shown to be uniformly stable with respect to the small parameter, consistent with the fluid-diffusion limit…

Numerical Analysis · Mathematics 2017-10-24 Abdelghani Bellouquid , Jacques Tagoudjeu

We study an anomalous behavior observed in interacting E. coli populations. When two populations of E. coli are placed on opposite ends of a long channel with a supply of nutrient between them, they will travel as pulses toward one another…

Cell Behavior · Quantitative Biology 2017-04-25 Glenn Young , Mahmut Demir , Hanna Salman , G. Bard Ermentrout , Jonathan E. Rubin

This manuscript deals with the three-dimensional version of a flux-limited Keller-Segel system coupled to the incompressible Stokes equations through transport and buoyancy. The main goal consists in verifying that within a certain…

Analysis of PDEs · Mathematics 2020-09-16 Michael Winkler

A connection is established between discrete stochastic model describing microscopic motion of fluctuating cells, and macroscopic equations describing dynamics of cellular density. Cells move towards chemical gradient (process called…

Biological Physics · Physics 2010-05-18 Pavel M. Lushnikov , Nan Chen , Mark Alber

Chemotaxis is the physical phenomenon that bacteria adjust their motions according to chemical stimulus. A classical model for this phenomenon is a kinetic equation that describes the velocity jump process whose tumbling/transition kernel…

Analysis of PDEs · Mathematics 2024-01-11 Kathrin Hellmuth , Christian Klingenberg , Qin Li , Min Tang

In this paper, we propose a kinetic model describing the collective motion by chemotaxis of two species in interaction emitting the same chemoattractant. Such model can be seen as a generalisation to several species of the Othmer-Dunbar-Alt…

Analysis of PDEs · Mathematics 2014-04-21 Luís Almeida , Casimir Emako , Nicolas Vauchelet

Originally motivated by the morphogenesis of bacterial microcolonies, the aim of this article is to explore models through different scales for a spatial population of interacting, growing and dividing particles. We start from a microscopic…

Analysis of PDEs · Mathematics 2025-01-07 Marie Doumic , Sophie Hecht , Marc Hoffmann , Diane Peurichard

The bacterium Escherichia coli (E. coli) moves in its natural environment in a series of straight runs, interrupted by tumbles which cause change of direction. It performs chemotaxis towards chemo-attractants by extending the duration of…

Quantitative Methods · Quantitative Biology 2010-07-12 Melissa Reneaux , Manoj Gopalakrishnan

Mathematical modelling of biological population dynamics often involves proposing high fidelity discrete agent-based models that capture stochasticity and individual-level processes. These models are often considered in conjunction with an…

Dynamical Systems · Mathematics 2023-12-20 Daniel J. VandenHeuvel , Pascal R. Buenzli , Matthew J. Simpson

Chemotaxis systems of Keller--Segel type constitute one of the central mathematical frameworks for understanding aggregation phenomena in biological and ecological systems. Over the past decades, the theory has evolved from the classical…

Analysis of PDEs · Mathematics 2026-03-06 Kolade M Owolabi , Eben Mare , Clara O Ijalana , Kolawole S Adegbie

We study the derivation of macroscopic traffic models out of optimal speed and follow-the-leader particle dynamics as hydrodynamic limits of non-local Povzner-type kinetic equations. As a first step, we show that optimal speed vehicle…

Statistical Mechanics · Physics 2023-03-13 Felisia Angela Chiarello , Andrea Tosin

Chemotaxis is a fundamental mechanism of cells and organisms, which is responsible for attracting microbes to food, embryonic cells into developing tissues, or immune cells to infection sites. Mathematically chemotaxis is described by the…

Analysis of PDEs · Mathematics 2020-09-30 Erika Hausenblas , Debopriya Mukherjee , Thanh Tran

A novel trait-structured Keller-Segel model that explores the dynamics of a migrating cell population guided by chemotaxis in response to an external ligand concentration is derived and analysed. Unlike traditional Keller-Segel models, this…

Cell Behavior · Quantitative Biology 2025-02-27 Viktoria Freingruber , Tommaso Lorenzi , Kevin J. Painter , Mariya Ptashnyk

Many mathematical models for biological phenomena, such as the spread of diseases, are based on reaction-diffusion equations for densities of interacting cell populations. We present a consistent derivation of reaction-diffusion equations…

Analysis of PDEs · Mathematics 2026-02-23 Marzia Bisi , Davide Cusseddu , Ana Jacinta Soares , Romina Travaglini

This paper deals with the micro-macro derivation of virus models coupled with a reaction diffusion models that generates the dynamics in space of the virus particles. The first part of the presentation focuses, starting from [5, 6] on a…

Dynamical Systems · Mathematics 2021-12-15 Diletta Burini , Nadia Chouhad

While the role of local interactions in nonequilibrium phase transitions is well studied, a fundamental understanding of the effects of long-range interactions is lacking. We study the critical dynamics of reproducing agents subject to…

Statistical Mechanics · Physics 2023-08-25 Jasper van der Kolk , Florian Rasshofer , Richard Swiderski , Astik Haldar , Abhik Basu , Erwin Frey

We consider an initial-boundary value problem describing the formation of colony patterns of bacteria Escherichia coli. This model consists of reaction-diffusion equations coupled with the Keller-Segel system from the chemotaxis theory in a…

Analysis of PDEs · Mathematics 2021-01-08 Rafał Celiński , Danielle Hilhorst , Grzegorz Karch , Masayasu Mimura , Pierre Roux