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Continuous-time Bayesian Networks (CTBNs) represent a compact yet powerful framework for understanding multivariate time-series data. Given complete data, parameters and structure can be estimated efficiently in closed-form. However, if…

Machine Learning · Statistics 2019-11-04 Dominik Linzner , Michael Schmidt , Heinz Koeppl

Boolean networks are powerful mathematical tools for modeling the qualitative dynamics of genetic regulation. Yet inferred models often generate spurious attractors that lack biological viability. In this paper, we propose a parsimonious…

Molecular Networks · Quantitative Biology 2026-04-30 Jacques Demongeot , Alonso Espinoza Rojas , Eric Goles , Marco Montalva-Medel , Sylvain Sené , Laurent Tichit

One of the most challenging tasks when adopting Bayesian Networks (BNs) is the one of learning their structure from data. This task is complicated by the huge search space of possible solutions, and by the fact that the problem is NP-hard.…

Machine Learning · Computer Science 2018-08-07 Stefano Beretta , Mauro Castelli , Ivo Goncalves , Roberto Henriques , Daniele Ramazzotti

A Bayesian net (BN) is more than a succinct way to encode a probabilistic distribution; it also corresponds to a function used to answer queries. A BN can therefore be evaluated by the accuracy of the answers it returns. Many algorithms for…

Artificial Intelligence · Computer Science 2013-02-08 Russell Greiner , Adam J. Grove , Dale Schuurmans

Neural networks have emerged as essential components in safety-critical applications -- these use cases demand complex, yet trustworthy computations. Binarized Neural Networks (BNNs) are a type of neural network where each neuron is…

Machine Learning · Computer Science 2025-07-08 Jiong Yang , Yong Kiam Tan , Mate Soos , Magnus O. Myreen , Kuldeep S. Meel

A Bayesian network is a widely used probabilistic graphical model with applications in knowledge discovery and prediction. Learning a Bayesian network (BN) from data can be cast as an optimization problem using the well-known…

Artificial Intelligence · Computer Science 2020-09-01 Zhenyu A. Liao , Charupriya Sharma , James Cussens , Peter van Beek

Despite the large quantity of information available, thorough researches in various biological databases are still needed in order to reconstruct and understand the steps that lead to known or new phenomena. By using protein-protein…

Molecular Networks · Quantitative Biology 2014-12-03 Alberto Calderone

Spatial Transformer Networks (STNs) estimate image transformations that can improve downstream tasks by `zooming in' on relevant regions in an image. However, STNs are hard to train and sensitive to mis-predictions of transformations. To…

Machine Learning · Computer Science 2022-06-16 Pola Schwöbel , Frederik Warburg , Martin Jørgensen , Kristoffer H. Madsen , Søren Hauberg

Boolean networks are a popular modeling framework in computational biology to capture the dynamics of molecular networks, such as gene regulatory networks. It has been observed that many published models of such networks are defined by…

Molecular Networks · Quantitative Biology 2019-12-06 Elijah Paul , Gleb Pogudin , William Qin , Reinhard Laubenbacher

Physics-informed neural networks and operator networks have shown promise for effectively solving equations modeling physical systems. However, these networks can be difficult or impossible to train accurately for some systems of equations.…

Machine Learning · Computer Science 2023-11-22 Amanda A Howard , Sarah H Murphy , Shady E Ahmed , Panos Stinis

Bayesian Neural Networks (BNNs) have been proposed to address the problem of model uncertainty in training and inference. By introducing weights associated with conditioned probability distributions, BNNs are capable of resolving the…

Machine Learning · Computer Science 2018-02-06 Ruizhe Cai , Ao Ren , Ning Liu , Caiwen Ding , Luhao Wang , Xuehai Qian , Massoud Pedram , Yanzhi Wang

Artificial neural networks (NNs) are one of the most frequently used machine learning approaches to construct interatomic potentials and enable efficient large-scale atomistic simulations with almost ab initio accuracy. However, the…

Computational Physics · Physics 2021-10-05 Viktor Zaverkin , David Holzmüller , Ingo Steinwart , Johannes Kästner

The graph structure of a Bayesian network (BN) can be learned from data using the well-known score-and-search approach. Previous work has shown that incorporating structured representations of the conditional probability distributions…

Machine Learning · Computer Science 2022-06-22 Charupriya Sharma , Peter van Beek

We present an algorithm for model-based reinforcement learning that combines Bayesian neural networks (BNNs) with random roll-outs and stochastic optimization for policy learning. The BNNs are trained by minimizing $\alpha$-divergences,…

Machine Learning · Statistics 2017-03-09 Stefan Depeweg , José Miguel Hernández-Lobato , Finale Doshi-Velez , Steffen Udluft

Detailed modeling and simulation of biochemical systems is complicated by the problem of combinatorial complexity, an explosion in the number of species and reactions due to myriad protein-protein interactions and post-translational…

Quantitative Methods · Quantitative Biology 2014-05-20 Justin S. Hogg , Leonard A. Harris , Lori J. Stover , Niketh S. Nair , James R. Faeder

The increasing complexity of modern deep neural network models and the expanding sizes of datasets necessitate the development of optimized and scalable training methods. In this white paper, we addressed the challenge of efficiently…

Machine Learning · Computer Science 2024-04-29 Raphael Ruschel , A. S. M. Iftekhar , B. S. Manjunath , Suya You

As one of the energy-efficient alternatives of conventional neural networks (CNNs), spiking neural networks (SNNs) have gained more and more interest recently. To train the deep models, some effective batch normalization (BN) techniques are…

Computer Vision and Pattern Recognition · Computer Science 2023-08-17 Yufei Guo , Yuhan Zhang , Yuanpei Chen , Weihang Peng , Xiaode Liu , Liwen Zhang , Xuhui Huang , Zhe Ma

Random Boolean networks (RBNs) have been a popular model of genetic regulatory networks for more than four decades. However, most RBN studies have been made with random topologies, while real regulatory networks have been found to be…

Cellular Automata and Lattice Gases · Physics 2015-03-17 Rodrigo Poblanno-Balp , Carlos Gershenson

A probabilistic structure on sequential dynamical systems is introduced here, the new model will be called Probabilistic Sequential Network, PSN. The morphisms of Probabilistic Sequential Networks are defined using two algebraic conditions.…

Genomics · Quantitative Biology 2008-04-30 Maria A. Avino-Diaz

In many neuromorphic workflows, simulators play a vital role for important tasks such as training spiking neural networks (SNNs), running neuroscience simulations, and designing, implementing and testing neuromorphic algorithms. Currently…

Neural and Evolutionary Computing · Computer Science 2023-05-05 Prasanna Date , Chathika Gunaratne , Shruti Kulkarni , Robert Patton , Mark Coletti , Thomas Potok