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Imputing data is a critical issue for machine learning practitioners, including in the life sciences domain, where missing clinical data is a typical situation and the reliability of the imputation is of great importance. Currently, there…

Quantum Physics · Physics 2023-12-13 Skander Kazdaghli , Iordanis Kerenidis , Jens Kieckbusch , Philip Teare

Machine learning algorithms permeate the day-to-day aspects of our lives and therefore studying the fairness of these algorithms before implementation is crucial. One way in which bias can manifest in a dataset is through missing values.…

Machine Learning · Statistics 2026-02-23 Aeysha Bhatti , Trudie Sandrock , Johane Nienkemper-Swanepoel

As more Intensive Care Unit (ICU) data becomes available, the interest in developing clinical prediction models to improve healthcare protocols increases. However, the lack of data quality still hinders clinical prediction using Machine…

Artificial intelligence (AI) systems built on incomplete or biased data will often exhibit problematic outcomes. Current methods of data analysis, particularly before model development, are costly and not standardized. The Dataset Nutrition…

Databases · Computer Science 2018-05-11 Sarah Holland , Ahmed Hosny , Sarah Newman , Joshua Joseph , Kasia Chmielinski

Machine learning risks reinforcing biases present in data and, as we argue in this work, in what is absent from data. In healthcare, societal and decision biases shape patterns in missing data, yet the algorithmic fairness implications of…

Artificial Intelligence · Computer Science 2025-03-19 Vincent Jeanselme , Maria De-Arteaga , Zhe Zhang , Jessica Barrett , Brian Tom

Medical datasets are typically affected by issues such as missing values, class imbalance, a heterogeneous feature types, and a high number of features versus a relatively small number of samples, preventing machine learning models from…

Clinical prediction models must be developed using sufficiently large datasets to minimise overfitting and ensure robust predictive performance. Existing sample size calculations assume complete predictor data for all included participants,…

Missing data is a common problem in clinical data collection, which causes difficulty in the statistical analysis of such data. To overcome problems caused by incomplete data, we propose a new imputation method called projective resampling…

Methodology · Statistics 2021-06-17 Zishu Zhan , Xiangjie Li , Jingxiao Zhang

Modern data acquisition based on high-throughput technology is often facing the problem of missing data. Algorithms commonly used in the analysis of such large-scale data often depend on a complete set. Missing value imputation offers a…

Applications · Statistics 2014-06-03 Daniel J. Stekhoven , Peter Bühlmann

Imputing missing values is an important preprocessing step in data analysis, but the literature offers little guidance on how to choose between different imputation models. This letter suggests adopting the imputation model that generates a…

Methodology · Statistics 2021-07-13 Moritz Marbach

Missing values are a major challenge in most data science projects working on real data. To avoid losing valuable information, imputation methods are used to fill in missing values with estimates, allowing the preservation of samples or…

Machine Learning · Computer Science 2024-07-17 Pedro Pons-Suñer , Laura Arnal , J. Ramón Navarro-Cerdán , François Signol

We investigate methods for penalized regression in the presence of missing observations. This paper introduces a method for estimating the parameters which compensates for the missing observations. We first, derive an unbiased estimator of…

Applications · Statistics 2013-10-09 Yunjin Choi , Robert Tibshirani

Dealing with missing modalities in Magnetic Resonance Imaging (MRI) and overcoming their negative repercussions is considered a hurdle in biomedical imaging. The combination of a specified set of modalities, which is selected depending on…

Image and Video Processing · Electrical Eng. & Systems 2022-03-15 Reza Azad , Nika Khosravi , Mohammad Dehghanmanshadi , Julien Cohen-Adad , Dorit Merhof

Background: Data preparation, such as missing values imputation and transformation, is the first step in any data analysis and requires crucial attention. Particularly, analysis of metabolites demands more preparation since those small…

Quantitative Methods · Quantitative Biology 2019-05-14 Akram Yazdani , Azam Yazdan

Performance metrics for medical image segmentation models are used to measure the agreement between the reference annotation and the predicted segmentation. Usually, overlap metrics, such as the Dice, are used as a metric to evaluate the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Sophie Ostmeier , Brian Axelrod , Jeroen Bertels , Fabian Isensee , Maarten G. Lansberg , Soren Christensen , Gregory W. Albers , Li-Jia Li , Jeremy J. Heit

Public policy-makers use cost-effectiveness analyses (CEA) to decide which health and social care interventions to provide. Appropriate methods have not been developed for handling missing data in complex settings, such as for CEA that use…

Methodology · Statistics 2012-06-27 Karla Diaz-Ordaz , Michael G. Kenward , Richard Grieve

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial…

Data from discovery proteomic and phosphoproteomic experiments typically include missing values that correspond to proteins that have not been identified in the analyzed sample. Replacing the missing values with random numbers, a process…

Quantitative Methods · Quantitative Biology 2019-10-01 Matus Medo , Daniel M. Aebersold , Michaela Medova

The explainability of deep learning models remains a significant challenge, particularly in the medical domain where interpretable outputs are essential for clinical trust and transparency. Path attribution methods such as Integrated…

Machine Learning · Computer Science 2026-05-08 Alexander Geiger , Lars Wagner , Daniel Rueckert , Dirk Wilhelm , Alissa Jell

Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

Machine Learning · Computer Science 2023-04-18 Omer Noy , Ron Shamir
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