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We consider the problem of learning a sparse graph underlying an undirected Gaussian graphical model, a key problem in statistical machine learning. Given $n$ samples from a multivariate Gaussian distribution with $p$ variables, the goal is…

Machine Learning · Computer Science 2026-04-07 Kayhan Behdin , Wenyu Chen , Rahul Mazumder

Gaussian process factor analysis (GPFA) is a latent variable modeling technique commonly used to identify smooth, low-dimensional latent trajectories underlying high-dimensional neural recordings. Specifically, researchers model spiking…

Machine Learning · Computer Science 2024-05-21 Yididiya Y. Nadew , Xuhui Fan , Christopher J. Quinn

Neural population activity exhibits complex, nonlinear dynamics, varying in time, over trials, and across experimental conditions. Here, we develop Conditionally Linear Dynamical System (CLDS) models as a general-purpose method to…

Neurons and Cognition · Quantitative Biology 2025-10-31 Victor Geadah , Amin Nejatbakhsh , David Lipshutz , Jonathan W. Pillow , Alex H. Williams

Neuroscience is experiencing a data revolution in which many hundreds or thousands of neurons are recorded simultaneously. Currently, there is little consensus on how such data should be analyzed. Here we introduce LFADS (Latent Factor…

Machine Learning · Computer Science 2016-08-24 David Sussillo , Rafal Jozefowicz , L. F. Abbott , Chethan Pandarinath

Gaussian Process (GP) regression models typically assume that residuals are Gaussian and have the same variance for all observations. However, applications with input-dependent noise (heteroscedastic residuals) frequently arise in practice,…

Machine Learning · Statistics 2012-12-27 Chunyi Wang , Radford M. Neal

We introduce Variational Latent Mode Decomposition (VLMD), a new algorithm for extracting oscillatory modes and associated connectivity structures from multivariate signals. VLMD addresses key limitations of existing Multivariate Mode…

Machine Learning · Computer Science 2025-05-26 Manuel Morante , Naveed ur Rehman

We propose a nonparametric procedure to achieve fast inference in generative graphical models when the number of latent states is very large. The approach is based on iterative latent variable preselection, where we alternate between…

Machine Learning · Statistics 2021-10-06 Jacquelyn A. Shelton , Jan Gasthaus , Zhenwen Dai , Joerg Luecke , Arthur Gretton

Selecting key variables from high-dimensional data is increasingly important in the era of big data. Sparse regression serves as a powerful tool for this purpose by promoting model simplicity and explainability. In this work, we revisit a…

Machine Learning · Computer Science 2025-09-09 Hyungjoon Soh , Dongha Lee , Vipul Periwal , Junghyo Jo

This paper considers a stochastic control framework, in which the residual model uncertainty of the dynamical system is learned using a Gaussian Process (GP). In the proposed formulation, the residual model uncertainty consists of a…

Systems and Control · Electrical Eng. & Systems 2023-05-26 Marcel Menner , Karl Berntorp

Sampling-based algorithms, which eliminate ''unimportant'' computations during forward and/or back propagation (BP), offer potential solutions to accelerate neural network training. However, since sampling introduces approximations to…

Machine Learning · Computer Science 2024-02-28 Ziteng Wang , Jianfei Chen , Jun Zhu

Modeling neural population dynamics underlying noisy single-trial spiking activities is essential for relating neural observation and behavior. A recent non-recurrent method - Neural Data Transformers (NDT) - has shown great success in…

Neurons and Cognition · Quantitative Biology 2022-06-13 Trung Le , Eli Shlizerman

The data-driven recovery of the unknown governing equations of dynamical systems has recently received an increasing interest. However, the identification of governing equations remains challenging when dealing with noisy and partial…

Machine Learning · Computer Science 2021-02-17 Duong Nguyen , Said Ouala , Lucas Drumetz , Ronan Fablet

Recent advances in the field of meta-learning have tackled domains consisting of large numbers of small ("few-shot") supervised learning tasks. Meta-learning algorithms must be able to rapidly adapt to any individual few-shot task, fitting…

Machine Learning · Computer Science 2021-10-22 Vivek Myers , Nikhil Sardana

Systems neuroscience relies on two complementary views of neural data, characterized by single neuron tuning curves and analysis of population activity. These two perspectives combine elegantly in neural latent variable models that…

Sequential learning with Gaussian processes (GPs) is challenging when access to past data is limited, for example, in continual and active learning. In such cases, errors can accumulate over time due to inaccuracies in the posterior,…

Machine Learning · Computer Science 2023-06-07 Paul E. Chang , Prakhar Verma , S. T. John , Arno Solin , Mohammad Emtiyaz Khan

Background: Spike trains of multiple neurons can be analyzed following the summed population (SP) or the labeled line (LL) hypothesis. Responses to external stimuli are generated by a neuronal population as a whole or the individual neurons…

Neurons and Cognition · Quantitative Biology 2018-09-17 Eero Satuvuori , Mario Mulansky , Andreas Daffertshofer , Thomas Kreuz

The problem of catastrophic forgetting occurs in deep learning models trained on multiple databases in a sequential manner. Recently, generative replay mechanisms (GRM), have been proposed to reproduce previously learned knowledge aiming to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-21 Fei Ye , Adrian G. Bors

It is difficult to anticipate the myriad challenges that a predictive model will encounter once deployed. Common practice entails a reactive, cyclical approach: model deployment, data mining, and retraining. We instead develop a proactive…

Multi-Output Gaussian Processes (MOGPs) provide a principled probabilistic framework for modelling correlated outputs but face scalability bottlenecks when applied to datasets with high-dimensional output spaces. To maintain tractability,…

Machine Learning · Computer Science 2026-05-29 Xiaoyu Jiang , Xinxing Shi , Sokratia Georgaka , Magnus Rattray , Mauricio A Álvarez

Gaussian processes are a flexible Bayesian nonparametric modelling approach that has been widely applied but poses computational challenges. To address the poor scaling of exact inference methods, approximation methods based on sparse…

Machine Learning · Statistics 2021-06-01 Rui Meng , Herbert Lee , Soper Braden , Priyadip Ray