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Obtaining effective representations of DNA sequences is crucial for genome analysis. Metagenomic binning, for instance, relies on genome representations to cluster complex mixtures of DNA fragments from biological samples with the aim of…

Machine Learning · Computer Science 2024-11-05 Abdulkadir Celikkanat , Andres R. Masegosa , Thomas D. Nielsen

Compared with electrical neural networks, optical neural networks (ONNs) have the potentials to break the limit of the bandwidth and reduce the consumption of energy, and therefore draw much attention in recent years. By far, several types…

Optics · Physics 2024-02-02 Yifan Sun , Qian Li , Ling-Jun Kong , Xiangdong Zhang

Molecular docking is a key task in computational biology that has attracted increasing interest from the machine learning community. While existing methods have achieved success, they generally treat each protein-ligand pair in isolation.…

Biomolecules · Quantitative Biology 2025-01-28 Jiaqi Guan , Jiahan Li , Xiangxin Zhou , Xingang Peng , Sheng Wang , Yunan Luo , Jian Peng , Jianzhu Ma

Ontology Alignment (OA) is essential for enabling semantic interoperability across heterogeneous knowledge systems. While recent advances have focused on large language models (LLMs) for capturing contextual semantics, this work revisits…

Artificial Intelligence · Computer Science 2025-10-01 Hamed Babaei Giglou , Jennifer D'Souza , Sören Auer , Mahsa Sanaei

Conformal blocks in odd spacetime dimensions are not known in closed analytic form. To facilitate efficient computations in the conformal bootstrap, we introduce $\texttt{GoBlocks}$: a novel conformal-block generator implemented in the Go…

High Energy Physics - Theory · Physics 2026-04-17 James Chryssanthacopoulos , Vasilis Niarchos , Constantinos Papageorgakis , Alexander G. Stapleton

Drug toxicity remains a major challenge in pharmaceutical development. Recent machine learning models have improved in silico toxicity prediction, but their reliance on annotated data and lack of interpretability limit their applicability.…

Machine Learning · Computer Science 2025-11-06 Jueon Park , Yein Park , Minju Song , Soyon Park , Donghyeon Lee , Seungheun Baek , Jaewoo Kang

The pre-trained language models are continually fine-tuned to better support downstream applications. However, this operation may result in significant performance degeneration on general tasks beyond the targeted domain. To overcome this…

Computation and Language · Computer Science 2023-12-11 Shitao Xiao , Zheng Liu , Peitian Zhang , Xingrun Xing

Multi-task learning (MTL) benefits the fine-tuning of large language models (LLMs) by providing a single model with improved performance and generalization ability across tasks, presenting a resource-efficient alternative to developing…

Computation and Language · Computer Science 2024-10-29 Zi Gong , Hang Yu , Cong Liao , Bingchang Liu , Chaoyu Chen , Jianguo Li

Although DNA foundation models have advanced the understanding of genomes, they still face significant challenges in the limited scale and diversity of genomic data. This limitation starkly contrasts with the success of natural language…

Genomics · Quantitative Biology 2024-02-14 Huixin Zhan , Ying Nian Wu , Zijun Zhang

We present Caffe con Troll (CcT), a fully compatible end-to-end version of the popular framework Caffe with rebuilt internals. We built CcT to examine the performance characteristics of training and deploying general-purpose convolutional…

Machine Learning · Computer Science 2015-05-28 Stefan Hadjis , Firas Abuzaid , Ce Zhang , Christopher Ré

Accurate interpretation of 12 lead electrocardiograms (ECGs) is critical for early detection of cardiac abnormalities, yet manual reading is error prone and existing CNN based classifiers struggle to choose receptive field sizes that…

Signal Processing · Electrical Eng. & Systems 2025-10-30 Dong-Hyeon Kang , Ju-Hyeon Nam , Sang-Chul Lee

Previous work has suggested that the structural restrictions of graphs from classes of bounded expansion--locally dense pockets in a globally sparse graph--naturally coincide with common properties of real-world networks such as clustering…

Data Structures and Algorithms · Computer Science 2018-04-24 Michael P. O'Brien , Blair D. Sullivan

We present a self-supervised learning framework, COCO-LM, that pretrains Language Models by COrrecting and COntrasting corrupted text sequences. Following ELECTRA-style pretraining, COCO-LM employs an auxiliary language model to corrupt…

Computation and Language · Computer Science 2021-10-28 Yu Meng , Chenyan Xiong , Payal Bajaj , Saurabh Tiwary , Paul Bennett , Jiawei Han , Xia Song

Recent work has demonstrated that graph neural networks (GNNs) trained for charged particle tracking can match the performance of traditional algorithms while improving scalability to prepare for the High Luminosity LHC experiment. Most…

Data Analysis, Statistics and Probability · Physics 2023-10-02 Kilian Lieret , Gage DeZoort

This paper describes an integrated framework for SOC test automation. This framework is based on a new approach for Wrapper/TAM co-optimization based on rectangle packing considering the diagonal length of the rectangles to emphasize on…

Other Computer Science · Computer Science 2010-08-27 Hafiz Md. Hasan Babu , Md. Rafiqul Islam , Muhammad Rezaul Karim , Abdullah Al Mahmud , Md. Saiful Islam

Recent work in time series forecasting has explored reformulating regression as a classification task. By discretizing the continuous target space into bins and predicting over a fixed set of classes, these approaches benefit from more…

Machine Learning · Computer Science 2025-08-28 Andrei Chernov , Vitaliy Pozdnyakov , Ilya Makarov

Metagenomic binning aims to cluster DNA fragments from mixed microbial samples into their respective genomes, a critical step for downstream analyses of microbial communities. Existing methods rely on deterministic representations, such as…

Machine Learning · Computer Science 2025-10-01 Abdulkadir Celikkanat , Andres R. Masegosa , Mads Albertsen , Thomas D. Nielsen

We establish a broad methodological foundation for mixed-integer optimization with learned constraints. We propose an end-to-end pipeline for data-driven decision making in which constraints and objectives are directly learned from data…

Optimization and Control · Mathematics 2023-10-30 Donato Maragno , Holly Wiberg , Dimitris Bertsimas , S. Ilker Birbil , Dick den Hertog , Adejuyigbe Fajemisin

Convolutional neural network (CNN) dataflow inference accelerators implemented in Field Programmable Gate Arrays (FPGAs) have demonstrated increased energy efficiency and lower latency compared to CNN execution on CPUs or GPUs. However, the…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-03-30 Mairin Kroes , Lucian Petrica , Sorin Cotofana , Michaela Blott

Ultra-fine-grained image recognition (UFGIR) is a challenging task that involves classifying images within a macro-category. While traditional FGIR deals with classifying different species, UFGIR goes beyond by classifying sub-categories…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Edwin Arkel Rios , Jansen Christopher Yuanda , Vincent Leon Ghanz , Cheng-Wei Yu , Bo-Cheng Lai , Min-Chun Hu