Related papers: Single-Molecule Protein Identification by Sub-Nano…
A Single-Photon Detector (SPD) can detect extremely low intensity of electromagnetic wave - down to a single photon. Driven by the rapid developments in quantum information science and an increasing demand for ultra-low-light sensing across…
Room temperature detection of molecular vibrations in the mid-infrared (MIR, $\lambda$ =3-30$\mu$m) has numerous applications including real-time gas sensing, chemical reactivity, medical imaging, astronomical surveys, and quantum…
Sequence coverage in MS analysis of protein digestion-derived peptides is a key issue for detailed characterization of proteins or identification at low quantities. In gel-based proteomics studies, the sequence coverage greatly depends on…
The translocation of a macromolecule through a nanometer-sized pore is an interesting process with important applications in the development of biosensors for single--molecule analysis and in drug delivery and gene therapy. We have carried…
When nanoparticles (NPs) are introduced into a biological solution, layers of biomolecules form on their surface, creating a corona. Understanding how the structure of the protein evolves into the corona is essential for evaluating the…
Integrated arrays of Superconducting Nanowire Single Photon Detectors (SNSPDs) have shown capabilities such as Photon Number Resolution, single photon imaging and coincidences detection, and can be effectively used also in other different…
State-of-the-art Superconducting Nanowire Single Photon Detectors based on low-Tc materials reach 100% quantum efficiency. However, the response time is limited to >1-10 ns. Recently, it has been shown that due to a much lower kinetic…
Nanopore sequencing technology remains highly error-prone, making efficient error correction essential in DNA-based data storage. Prior work addressed high error rates using convolutional codes with their decoder coupled with the…
The mode of action of proteins is to a large extent given by their ability to adopt different conformations. This is why imaging single biomolecules at atomic resolution is one of the ultimate goals of biophysics and structural biology. The…
Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…
Shortly after their inception, superconducting nanowire single-photon detectors (SNSPDs) became the leading quantum light detection technology. With the capability of detecting single-photons with near-unity efficiency, high time…
Optical interfaces for quantum emitters are a prerequisite for implementing quantum networks. Here, we couple single molecules to the guided modes of an optical nanofiber. The molecules are embedded within a crystal that provides…
Mass spectrometry imaging (MSI) as an analytical tool for bio-molecular and bio-medical research targets, accurate compound localization and identification. In terms of dedicated instrumentation, this translates into the demand for more…
The detection of individual photons is an inherently binary mechanism, revealing either their absence or presence while concealing their spectral information. For multi-color imaging techniques, such as single photon spectroscopy,…
Signal processing (SP) techniques convert DNA and protein sequences into information that lead to successful drug discovery. One must, however, be aware about the difference between information and entropy1. Eight other physical properties…
Photon-number resolving (PNR) single-photon detectors are an enabling technology in many areas such as photonic quantum computing, non-classical light source characterisation and quantum imaging. Here, we demonstrate high-efficiency PNR…
Superconducting nanowire single photon detectors (SNSPDs) are a leading detector technology for time-resolved single-photon counting from the ultraviolet to the near-infrared regime. The recent advancement in single-photon sensitivity in…
The integration and parallelization of nanopore sensors are essential for improving the throughput of nanopore measurements. Solid-state nanopores traditionally have been used in isolation, which prevents the realization of their full…
Mass spectrometry is the dominant technology in the field of proteomics, enabling high-throughput analysis of the protein content of complex biological samples. Due to the complexity of the instrumentation and resulting data, sophisticated…
We present a novel design of a superconducting nanowire single photon detector (SNSPD) fabricated on a core of a single mode optical fiber. The proposed design allows high overlap between the fiber light mode and the detector, and…