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Disease subtype identification (clustering) is an important problem in biomedical research. Gene expression profiles are commonly utilized to infer disease subtypes, which often lead to biologically meaningful insights into disease. Despite…

Methodology · Statistics 2016-09-27 Jiehuan Sun , Joshua L. Warren , Hongyu Zhao

Bayesian model selection is premised on the assumption that the data are generated from one of the postulated models. However, in many applications, all of these models are incorrect (that is, there is misspecification). When the models are…

Methodology · Statistics 2021-12-10 Jonathan H. Huggins , Jeffrey W. Miller

Structure learning of Bayesian networks has always been a challenging problem. Nowadays, massive-size networks with thousands or more of nodes but fewer samples frequently appear in many areas. We develop a divide-and-conquer framework,…

Machine Learning · Statistics 2020-09-24 Jiaying Gu , Qing Zhou

Bayesian inference is now a leading technique for reconstructing phylogenetic trees from aligned sequence data. In this short note, we formally show that the maximum posterior tree topology provides a statistically consistent estimate of a…

Populations and Evolution · Quantitative Biology 2013-07-12 Mike Steel

A model involving Gaussian processes (GPs) is introduced to simultaneously handle multi-task learning, clustering, and prediction for multiple functional data. This procedure acts as a model-based clustering method for functional data as…

Machine Learning · Computer Science 2023-01-24 Arthur Leroy , Pierre Latouche , Benjamin Guedj , Servane Gey

Comparing and aligning large datasets is a pervasive problem occurring across many different knowledge domains. We introduce and study MREC, a recursive decomposition algorithm for computing matchings between data sets. The basic idea is to…

Machine Learning · Statistics 2020-02-24 Andrew J. Blumberg , Mathieu Carriere , Michael A. Mandell , Raul Rabadan , Soledad Villar

Evolution is a process that is influenced by various environmental factors, e.g. the interactions between different species, genes, and biogeographical properties. Hence, it is interesting to study the combined evolutionary history of…

Quantitative Methods · Quantitative Biology 2013-08-02 Nicolas Wieseke , Matthias Bernt , Martin Middendorf

Phylogenetic networks are a type of directed acyclic graph that represent how a set $X$ of present-day species are descended from a common ancestor by processes of speciation and reticulate evolution. In the absence of reticulate evolution,…

Combinatorics · Mathematics 2017-08-11 Andrew Francis , Charles Semple , Mike Steel

Clustering analysis identifies samples as groups based on either their mutual closeness or homogeneity. In order to detect clusters in arbitrary shapes, a novel and generic solution based on boundary erosion is proposed. The clusters are…

Computer Vision and Pattern Recognition · Computer Science 2018-04-16 Cheng-Hao Deng , Wan-Lei Zhao

Compared to abundant classical statistics-based literature, to date, very little Bayesian literature exists on Procrustes shape analysis in Geometric Morphometrics, probably because of being a relatively new branch of statistical research…

Methodology · Statistics 2021-01-20 Debashis Chatterjee

The Cross-Entropy Method (CEM) is a widely adopted trajectory optimizer in model-based reinforcement learning (MBRL), but its unimodal sampling strategy often leads to premature convergence in multimodal landscapes. In this work, we propose…

Machine Learning · Computer Science 2025-07-02 Yuliang Gu , Hongpeng Cao , Marco Caccamo , Naira Hovakimyan

Spatial domain identification requires jointly modeling molecular signatures and physical coordinates, yet current tools frequently over-smooth biological boundaries, require user-specified cluster numbers, and lack principled multimodal…

Applications · Statistics 2026-05-18 Xin Li , Xiaofei Dong , Zhenke Duan , Lulu Shang , Xiao Wang , Xinyuan Song , Hanwen Ning , Guanyu Hu

This paper proposes a new class of predictive models for survival analysis called Generalized Bayesian Ensemble Survival Tree (GBEST). It is well known that survival analysis poses many different challenges, in particular when applied to…

Methodology · Statistics 2025-03-18 Elena Ballante , Pietro Muliere , Silvia Figini

Phylogenetic tree reconciliation is employed for the examination of coevolution between host and symbiont species. An important concern is the requirement for dependable cost values when selecting event-based parsimonious reconciliation.…

Quantitative Methods · Quantitative Biology 2023-08-30 Blerina Sinaimeri , Laura Urbini , Marie-France Sagot , Catherine Matias

We consider an extension of model-based clustering to the semi-supervised case, where some of the data are pre-labeled. We provide a derivation of the Bayesian Information Criterion (BIC) approximation to the Bayes factor in this setting.…

Methodology · Statistics 2016-04-28 Jordan Yoder , Carey E. Priebe

Bayesian inference provides a rigorous methodology for estimation and uncertainty quantification of parameters in geophysical forward models. Badlands (basin and landscape dynamics model) is a landscape evolution model that simulates…

There is a rich literature on clustering functional data with applications to time-series modeling, trajectory data, and even spatio-temporal applications. However, existing methods routinely perform global clustering that enforces…

Methodology · Statistics 2024-12-16 Tsung-Hung Yao , Suprateek Kundu

In Bayesian phylogenetics, our goal is to estimate the posterior distribution over phylogenetic trees. Markov chain Monte Carlo methods are widely used to approximate the phylogenetic posterior distributions. For large-scale sequence data,…

Methodology · Statistics 2026-05-12 Wentao Yu , Shijia Wang

Cluster analysis aims at partitioning data into groups or clusters. In applications, it is common to deal with problems where the number of clusters is unknown. Bayesian mixture models employed in such applications usually specify a…

Methodology · Statistics 2022-01-27 Jan Greve , Bettina Grün , Gertraud Malsiner-Walli , Sylvia Frühwirth-Schnatter

lcensemble is a high-performing, scalable and user-friendly Python package for the general tasks of classification and regression. The package implements Local Cascade Ensemble (LCE), a machine learning method that further enhances the…

Machine Learning · Computer Science 2023-08-17 Kevin Fauvel , Élisa Fromont , Véronique Masson , Philippe Faverdin , Alexandre Termier