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Time series classification (TSC) of biological signals has progressed from handcrafted, modality-specific approaches to deep architectures capable of representing the diverse waveform structures of underlying physiological processes (i.e.,…

The leaves of angiosperms contain highly complex venation networks consisting of recursively nested, hierarchically organized loops. We describe a new phenotypic trait of reticulate vascular networks based on the topology of the nested…

Quantitative Methods · Quantitative Biology 2016-06-23 Henrik Ronellenfitsch , Jana Lasser , Douglas C. Daly , Eleni Katifori

Deep predictive models of neuronal activity have recently enabled several new discoveries about the selectivity and invariance of neurons in the visual cortex. These models learn a shared set of nonlinear basis functions, which are linearly…

Neurons and Cognition · Quantitative Biology 2024-06-19 Polina Turishcheva , Max Burg , Fabian H. Sinz , Alexander Ecker

We use methods from computational algebraic topology to study functional brain networks, in which nodes represent brain regions and weighted edges encode the similarity of fMRI time series from each region. With these tools, which allow one…

Quantitative Methods · Quantitative Biology 2020-08-27 Bernadette J. Stolz , Tegan Emerson , Satu Nahkuri , Mason A. Porter , Heather A. Harrington

Directional media, such as nematic liquid crystals and ferromagnets, are characterized by their topologically stabilized defects in directional order. In nematics, boundary conditions and surface-treated inclusions often create complex…

Soft Condensed Matter · Physics 2015-06-03 Simon Čopar , Slobodan Žumer

Given a 3D surface defined by an elevation function on a 2D grid as well as non-spatial features observed at each pixel, the problem of surface segmentation aims to classify pixels into contiguous classes based on both non-spatial features…

Computer Vision and Pattern Recognition · Computer Science 2020-08-27 Wenchong He , Arpan Man Sainju , Zhe Jiang , Da Yan

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

Tensor-based morphometry (TBM) aims at showing local differences in brain volumes with respect to a common template. TBM images are smooth but they exhibit (especially in diseased groups) higher values in some brain regions called lateral…

Topological data analysis (TDA) has become a powerful approach over the last twenty years, mainly due to its ability to capture the shape and the geometry inherent in the data. Persistence homology, which is a particular tool in TDA, has…

Neurons and Cognition · Quantitative Biology 2024-01-12 Anass B. El-Yaagoubi , Shuhao Jiao , Moo K. Chung , Hernando Ombao

Diabetic neuropathy is a disorder characterized by impaired nerve function and reduction of the number of epidermal nerve fibers per epidermal surface. Additionally, as neuropathy related nerve fiber loss and regrowth progresses over time,…

A neural network with fixed topology can be regarded as a parametrization of functions, which decides on the correlations between functional variations when parameters are adapted. We propose an analysis, based on a differential geometry…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Marc Toussaint

Topological invariants have proved useful for analyzing emergent function as they characterize a property of the entire system, and are insensitive to local details, disorder, and noise. They support boundary states, which reduce the system…

Statistical Mechanics · Physics 2025-10-10 Jaime Agudo-Canalejo , Evelyn Tang

As a cornerstone in language modeling, tokenization involves segmenting text inputs into pre-defined atomic units. Conventional statistical tokenizers often disrupt constituent boundaries within words, thereby corrupting semantic…

Computation and Language · Computer Science 2025-07-11 Qingyang Zhu , Xiang Hu , Pengyu Ji , Wei Wu , Kewei Tu

Understanding the operation of biological and artificial networks remains a difficult and important challenge. To identify general principles, researchers are increasingly interested in surveying large collections of networks that are…

Machine Learning · Statistics 2022-01-14 Alex H. Williams , Erin Kunz , Simon Kornblith , Scott W. Linderman

Topological data analysis (TDA) is a branch of computational mathematics, bridging algebraic topology and data science, that provides compact, noise-robust representations of complex structures. Deep neural networks (DNNs) learn millions of…

We consider a family of structural descriptors for visual data, namely covariance descriptors (CovDs) that lie on a non-linear symmetric positive definite (SPD) manifold, a special type of Riemannian manifolds. We propose an improved…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Kai-Xuan Chen , Xiao-Jun Wu , Jie-Yi Ren , Rui Wang , Josef Kittler

In this paper we present an approach to determine the smallest possible number of neurons in a layer of a neural network in such a way that the topology of the input space can be learned sufficiently well. We introduce a general procedure…

Machine Learning · Statistics 2026-03-24 Luciano Melodia , Richard Lenz

Deep learning has proven to successfully learn variations in tissue and cell morphology. Training of such models typically relies on expensive manual annotations. Here we conjecture that spatially resolved gene expression, e.i., the…

Quantitative Methods · Quantitative Biology 2023-12-11 Axel Andersson , Gabriele Partel , Leslie Solorzano , Carolina Wählby

Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices…

The organization in brain networks shows highly modular features with weak inter-modular interaction. The topology of the networks involves emergence of modules and sub-modules at different levels of constitution governed by fractal laws.…

Neurons and Cognition · Quantitative Biology 2015-09-22 Soibam Shyamchand Singh , Khundrakpam Budhachandra Singh , Romana Ishrat , B. Indrajit Sharma , R. K. Brojen Singh
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