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Motivated by two case studies using primary care records from the Clinical Practice Research Datalink, we describe statistical methods that facilitate the analysis of tall data, with very large numbers of observations. Our focus is on…

Methodology · Statistics 2018-05-14 Kirsty Rhodes , Rebecca Turner , Rupert Payne , Ian White

Disaggregation regression has become an important tool in spatial disease mapping for making fine-scale predictions of disease risk from aggregated response data. By including high resolution covariate information and modelling the data…

Applications · Statistics 2020-05-08 Rohan Arambepola , Tim C D Lucas , Anita K Nandi , Peter W Gething , Ewan Cameron

Important objectives in cancer research are the prediction of a patient's risk based on molecular measurements such as gene expression data and the identification of new prognostic biomarkers (e.g. genes). In clinical practice, this is…

Applications · Statistics 2020-04-17 Katrin Madjar , Manuela Zucknick , Katja Ickstadt , Jörg Rahnenführer

We present a novel coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant…

Biological Physics · Physics 2009-11-06 G. Getz , E. Levine , E. Domany

Federated learning promises to make machine learning feasible on distributed, private datasets by implementing gradient descent using secure aggregation methods. The idea is to compute a global weight update without revealing the…

Machine Learning · Computer Science 2019-12-03 Badih Ghazi , Rasmus Pagh , Ameya Velingker

Studies of the effects of medical interventions increasingly take place in distributed research settings using data from multiple clinical data sources including electronic health records and administrative claims. In such settings, privacy…

Methodology · Statistics 2021-01-06 Martijn J. Schuemie , Yong Chen , David Madigan , Marc A. Suchard

Cluster-randomized experiments are widely used due to their logistical convenience and policy relevance. To analyze them properly, we must address the fact that the treatment is assigned at the cluster level instead of the individual level.…

Methodology · Statistics 2021-08-06 Fangzhou Su , Peng Ding

We study regression discontinuity designs when covariates are included in the estimation. We examine local polynomial estimators that include discrete or continuous covariates in an additive separable way, but without imposing any…

Econometrics · Economics 2019-07-02 Sebastian Calonico , Matias D. Cattaneo , Max H. Farrell , Rocio Titiunik

We introduce CoLN, Combined Learning of Neural network weights, a novel method to securely combine Machine Learning models over sensitive data with no sharing of data. With CoLN, local hosts use the same Neural Network architecture and base…

Machine Learning · Computer Science 2022-05-03 Aline R. Ioste , Alan M. Durham , Marcelo Finger

Protecting user privacy is a major concern for many machine learning systems that are deployed at scale and collect from a diverse set of population. One way to address this concern is by collecting and releasing data labels in an…

Machine Learning · Computer Science 2023-05-19 Lin Chen , Gang Fu , Amin Karbasi , Vahab Mirrokni

Objective: To investigate the impact of different logistic regression estimators applied to RDS samples obtained by simulation and real data. Methods: Four simulated populations were created combining different connectivity models, levels…

Multivariate count data are commonly encountered through high-throughput sequencing technologies in bioinformatics, text mining, or in sports analytics. Although the Poisson distribution seems a natural fit to these count data, its…

Computation · Statistics 2020-04-16 Sanjeena Subedi , Ryan Browne

A full parametric and linear specification may be insufficient to capture complicated patterns in studies exploring complex features, such as those investigating age-related changes in brain functional abilities. Alternatively, a partially…

Methodology · Statistics 2024-02-07 Jia Liang , Shuo Chen , Peter Kochunov , L Elliot Hong , Chixiang Chen

Causal inference analyses often use existing observational data, which in many cases has some clustering of individuals. In this paper we discuss propensity score weighting methods in a multilevel setting where within clusters individuals…

Applications · Statistics 2020-12-24 Youjin Lee , Trang Q. Nguyen , Elizabeth A. Stuart

For data with high-dimensional covariates but small to moderate sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of…

Methodology · Statistics 2015-01-19 Yuan Huang , Qingzhao Zhang , Sanguo Zhang , Jian Huang , Shuangge Ma

In this paper, we investigate community detection in networks in the presence of node covariates. In many instances, covariates and networks individually only give a partial view of the cluster structure. One needs to jointly infer the full…

Methodology · Statistics 2018-04-26 Bowei Yan , Purnamrita Sarkar

Compositional data sets are ubiquitous in science, including geology, ecology, and microbiology. In microbiome research, compositional data primarily arise from high-throughput sequence-based profiling experiments. These data comprise…

Statistics Theory · Mathematics 2019-03-05 Patrick L. Combettes , Christian L. Müller

We consider the privacy amplification properties of a sampling scheme in which a user's data is used in $k$ steps chosen randomly and uniformly from a sequence (or set) of $t$ steps. This sampling scheme has been recently applied in the…

Machine Learning · Computer Science 2026-02-20 Vitaly Feldman , Moshe Shenfeld

Analytics on personal data, such as individuals' mobility, financial, and health data can be of significant benefit to society. Such data is already collected by smartphones, apps and services today, but liberal societies have so far…

Nowadays, with the widespread of smartphones and other portable gadgets equipped with a variety of sensors, data is ubiquitous available and the focus of machine learning has shifted from being able to infer from small training samples to…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-07-07 Radu Cristian Ionescu
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