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Complex diseases can be modeled as damage to intracellular networks that results in abnormal cell behaviors. Network-based dynamic models such as Boolean models have been employed to model a variety of biological systems including those…

Biological Physics · Physics 2016-12-30 Gang Yang , Colin Campbell , Réka Albert

We investigate the evolution of Boolean networks subject to a selective pressure which favors robustness against noise, as a model of evolved genetic regulatory systems. By mapping the evolutionary process into a statistical ensemble and…

Disordered Systems and Neural Networks · Physics 2012-04-11 Tiago P. Peixoto

We demonstrate the effects of embedding subgraphs using a Boolean network, which is one of the discrete dynamical models for transcriptional regulatory networks. After comparing the dynamical properties of network embedded seven different…

Cellular Automata and Lattice Gases · Physics 2008-06-26 Chikoo Oosawa , Michael A. Savageau , Abdul S. Jarrah , Reinhard C. Laubenbacher , Eduardo D. Sontag

Gene regulatory networks can be successfully modeled as Boolean networks. A much discussed hypothesis says that such model networks reproduce empirical findings the best if they are tuned to operate at criticality, i.e. at the borderline…

Molecular Networks · Quantitative Biology 2016-10-12 Pablo Villegas , José Ruiz-Franco , Jorge Hidalgo , Miguel A. Muñoz

Floating-point neural networks dominate modern machine learning but incur substantial inference costs, motivating emerging interest in Boolean networks for resource-constrained deployments. Since Boolean networks use only Boolean…

Artificial Intelligence · Computer Science 2026-05-13 Shengpu Wang , Yuhao Mao , Yani Zhang , Martin Vechev

We consider a cubic nonlinear wave equation on a network and show that inspecting the normal modes of the graph, we can immediately identify which ones extend into nonlinear periodic orbits. Two main classes of nonlinear periodic orbits…

Pattern Formation and Solitons · Physics 2017-09-13 Jean-Guy Caputo , Imene Khames , Arnaud Knippel , Panayotis Panayotaros

We study the dynamics of discrete-time regulatory networks on random digraphs. For this we define ensembles of deterministic orbits of random regulatory networks, and introduce some statistical indicators related to the long-term dynamics…

Dynamical Systems · Mathematics 2009-11-13 Anne Cros , Antonio Morante , Edgardo Ugalde

We examine the dynamical properties of a single-layer convolutional recurrent network with a smooth sigmoidal activation function, for small values of the inputs and when the convolution kernel is unitary, so all eigenvalues lie exactly at…

Statistical Mechanics · Physics 2024-05-24 Aditi Chandra , Marcelo O. Magnasco

Graph convolutional neural networks (GCNNs) have emerged as powerful tools for analyzing graph-structured data, achieving remarkable success across diverse applications. However, the theoretical understanding of the stability of these…

Machine Learning · Computer Science 2025-10-28 Ning Zhang , Henry Kenlay , Li Zhang , Mihai Cucuringu , Xiaowen Dong

The concept of boolean autonomous deterministic regular asynchronous system has its origin in switching theory, the theory of modeling the switching circuits from the digital electrical engineering. The attribute boolean vaguely refers to…

Dynamical Systems · Mathematics 2014-12-18 Serban E. Vlad

In this report, we present a formal approach that addresses the problem of emergence of phase transitions in stochastic and attractive nonlinear threshold Boolean automata networks. Nonlinear networks considered are informally defined on…

Discrete Mathematics · Computer Science 2010-11-23 Jacques Demongeot , Sylvain Sené

A biological regulatory network can be modeled as a discrete function that contains all available information on network component interactions. From this function we can derive a graph representation of the network structure as well as of…

Discrete Mathematics · Computer Science 2009-10-09 Heike Siebert

Given a Boolean network BN and a subset A of attractors of BN, we study the problem of identifying a minimal subset C of vertices of BN, such that the dynamics of BN can reach from a state s in any attractor As in A to any attractor At in A…

Systems and Control · Computer Science 2018-06-29 Soumya Paul , Jun Pang , Cui Su

We consider a basic model of a dynamical distribution network, modeled as a directed graph with storage variables corresponding to every vertex and flow inputs corresponding to every edge, subject to unknown but constant inflows and…

Optimization and Control · Mathematics 2014-03-21 Jieqiang Wei , Arjan J. van der Schaft

This paper deals with the global stability of time-delayed dynamical networks. We show that for a time-delayed dynamical network with non-distributed delays the network and the corresponding non-delayed network are both either globally…

Dynamical Systems · Mathematics 2015-06-05 Lenonid Bunimovich , Benjamin Webb

A finite dynamical system is a system of multivariate functions over a finite alphabet used to model a network of interacting entities. The main feature of a finite dynamical system is its interaction graph, which indicates which local…

Combinatorics · Mathematics 2017-01-12 Maximilien Gadouleau

Despite their apparent simplicity, random Boolean networks display a rich variety of dynamical behaviors. Much work has been focused on the properties and abundance of attractors. The topologies of random Boolean networks with one input per…

Disordered Systems and Neural Networks · Physics 2009-11-11 Björn Samuelsson , Carl Troein

Boolean networks, inspired by gene regulatory networks, were developed to understand the complex behaviors observed in biological systems, with network attractors corresponding to biological phenotypes or cell types. In this article, we…

Molecular Networks · Quantitative Biology 2025-11-25 Venkata Sai Narayana Bavisetty , Matthew Wheeler , Reinhard Laubenbacher , Claus Kadelka

We realize autonomous Boolean networks by using logic gates in their autonomous mode-of-operation on a field-programmable gate array. This allows us to implement time-continuous systems with complex dynamical behaviors that can be…

Adaptation and Self-Organizing Systems · Physics 2013-12-16 David P. Rosin , Damien Rontani , Daniel J. Gauthier , Eckehard Schöll

Robust heteroclinic cycles are known to change stability in resonance bifurcations, which occur when an algebraic condition on the eigenvalues of the system is satisfied and which typically result in the creation or destruction of a…

Chaotic Dynamics · Physics 2019-10-03 Vivien Kirk , Claire Postlethwaite , Alastair M. Rucklidge